Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Toshinori Ohmine"'
Autor:
Shinya Tsutsumi, Toshinori Ohmine, Toshiyuki Kosaka, Kaoru Shimada, Makoto Koizumi, Masakatsu Kaneko, Keika Akahori, Satoshi Kimura, Junko Sone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2213-2216
2'-Deoxyguanosine residues of a 3',5'-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N2-methyl-2'-deoxyguanosine (m2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity th
Autor:
Hitoshi Hotoda, Makoto Koizumi, Toshinori Ohmine, Hidehiko Furukawa, Takashi Nishigaki, Koji Abe, Toshiyuki Kosaka, Shinya Tsutsumi, Junko Sone, Masakatsu Kaneko, Satoshi Kimura, Kaoru Shimada
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 17:243-252
Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which exhibits anti-HIV-1 activity, were partially replaced with glycerol-moieties. Compound 7 with two glycerylguanines at its 3′-end showed more potent anti-HIV-1 activity and more stabi
Autor:
Koji Abe, Toshinori Ohmine, Takashi Nishigaki, Masakatsu Kaneko, Hidehiko Furukawa, Toshiyuki Kosaka, Toshinori Agatsuma, Makoto Koizumi, Satoshi Kimura, Junko Sone, Hitoshi Hotoda, Rika Koga, Kenji Momota, Shinya Tsutsumi, Kaoru Shimada
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:2235-2243
We have determined that hexadeoxyribonucleotides (5′TGGGAG3′), with modified aromatic groups such as a trityl group at the 5′-end, have anti-HIV-1 activity in vitro. The 6-mer bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end had
Autor:
Toshiyuki Kosaka, Makoto Koizumi, Koji Abe, Hidehiko Furukawa, Rika Koga, Kenji Momota, Satoshi Kimura, Takashi Nishigakit, Kaoru Shimada, Hitoshi Hotoda, Toshinori Ohmine, Masakatsu Kaneko
Publikováno v:
Nucleosides and Nucleotides. 16:1205-1208
It has been determined that hexadeoxyribonucleotides (5′TGGGAG3′), which have modified aromatic groups such as the trityl group at the 5′-end, exhibit anti-HIV-1 activity in vitro. The 6-mer (S-1443) bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) gr
Autor:
Rika Koga, Takeshi Kinoshita, Kaoru Shimada, Makoto Koizumi, Toshinori Ohmine, Takashi Nishigaki, Masakatsu Kaneko, Hitoshi Hotoda, Hidehiko Furukawa, Satoshi Kimura, Kenji Momota
Publikováno v:
Nucleosides and Nucleotides. 15:531-538
Hexadeoxyribonucleotides (6-mers) having a 5′-TGGGAG-3′ sequence bearing hydrophobic substituents at their 5′-ends via phosphodiester linkages were prepared and evaluated for anti-HIV-1 activity in vitro. Some of these modified 6-mers showed we
Autor:
Tetsushi Katsube, Hiroto Kashiwase, Kaoru Shimada, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Takashi Nishigaki, Kenji Momota, Toshinori Ohmine, Satoshi Kimura
Publikováno v:
ChemInform. 31
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the comp
Autor:
Katsuko Mita-Honjo, Kumi Shimoda-Takano, Tokio Tani, Yo Takiguchi, Hidehiko Furukawa, Toshinori Ohmine, Ichiro Kawashima
Publikováno v:
DNA Sequence. 2:303-312
The homologue of the rat pancreatic elastase I gene was found in the human genome, but its transcription was completely suppressed in the adult human pancreas as we reported previously. In this study, we characterized the complete structure of the ei
Autor:
Tetsushi Katsube, Tomio Kimura, Miho Kazui, Hiroto Kashiwase, Takashi Nishigaki, Masahiko Hagihara, Tsuzaki Yasunori, Aikichi Iwamoto, Toshinori Ohmine, Tomoaki Komai, Makoto Yamashita, Nobuhiro Kobayashi
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(5)
Anti-HIV-1 activities and pharmacokinetics of a series of novel arylpiperazinyl fluoroquinolones are reported. Modification at the C-8 position with a trifluoromethyl group was superior to that with a difluoromethoxy group to achieve higher anti-HIV-
Autor:
Tomio Kimura, Masahiko Hagihara, Tetsushi Katsube, Hiroto Kashiwase, Takashi Nishigaki, Kaoru Shimada, Kenji Momota, Toshinori Ohmine, Satoshi Kimura, Tomoaki Komai
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(21)
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the comp
Autor:
Toshinori Agatsuma, Makoto Koizumi, Toshiyuki Kosaka, Junko Sone, Masakatsu Kaneko, Hidehiko Furukawa, Rika Koga, Takashi Nishigaki, Hitoshi Hotoda, Shinya Tsutsumi, Kaoru Shimada, Toshinori Ohmine, Satoshi Kimura, Koji Abe
Publikováno v:
Bioorganicmedicinal chemistry. 6(12)
We have found that a hexadeoxyribonucleotide (5′TGGGAG3′, R-95288), Koizumi, M. et al. Bioorganic & Medicinal Chemistry , 1997 , 5, 2235, bearing a 3,4-dibenzyloxybenzyl (3,4-DBB) group at the 5′-end and a 2-hydroxyethylphosphate at the 3′-en