Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Toshinori Hoshi"'
Autor:
Nirakar Sahoo, Kefan Yang, Ina Coburger, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has b
Externí odkaz:
https://doaj.org/article/845788ec9f91486e9f2c2f0cbd2a94fb
Autor:
Philipp Rühl, Johanna M. Langner, Jasmin Reidel, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Rühl et al. report the generation of ratiometric genetically encoded voltage indicators (GEVIs) and establish that they can be used in high-throughput automated imaging to measure compound membrane potential (Vm) in mammalian cells. This method is i
Externí odkaz:
https://doaj.org/article/d8fdccc7299e4650ba56c7bdfa3b227d
Publikováno v:
eLife, Vol 11 (2022)
ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secr
Externí odkaz:
https://doaj.org/article/11a4f7b8d0a745f1a7853228250ae526
Autor:
Gautam Damera, Kirk M Druey, Philip R Cooper, Vera P Krymskaya, Roy J Soberman, Yassine Amrani, Toshinori Hoshi, Christopher E Brightling, Reynold A Panettieri
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28504 (2012)
In severe asthma, bronchodilator- and steroid-insensitive airflow obstruction develops through unknown mechanisms characterized by increased lung airway smooth muscle (ASM) mass and stiffness. We explored the role of a Regulator of G-protein Signalin
Externí odkaz:
https://doaj.org/article/de3e4fc546244df895c5429b8532ccfe
Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na+ channels
Autor:
Guido Gessner, Mahdi Jamili, Pascal Tomczyk, Dirk Menche, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Biol Chem
Heme (Fe2+-protoporphyrin IX) is a well-known protein prosthetic group; however, heme and hemin (Fe3+-protoporphyrin IX) are also increasingly viewed as signaling molecules. Among the signaling targets are numerous ion channels, with intracellular-fa
ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1d9d9c279b8a5ae91dfce35460e322
https://doi.org/10.1101/2022.01.16.476512
https://doi.org/10.1101/2022.01.16.476512
Publikováno v:
ACS Chem Biol
Heme catabolism by heme oxygenase (HO) with a decrease in intracellular heme concentration and a concomitant local release of CO and Fe(2+) has potential to regulate BK(Ca) channels. Here we show that the iron-based photolabile CO-releasing molecule
Autor:
Alisa Bernert, Sandip M. Swain, Eric Wiesel, Nirakar Sahoo, Kefan Yang, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann, Ina Coburger
Publikováno v:
Pflugers Archiv
N-type inactivation of voltage-gated K+ channels is conferred by the N-terminal “ball” domains of select pore-forming α subunits or of auxiliary β subunits, and influences electrical cellular excitability. Here, we show that hemin impairs inact
Autor:
Nikita Kuldyushev, Roland Schönherr, Ina Coburger, Marwa Ahmed, Rama A. Hussein, Eric Wiesel, Amod Godbole, Thorsten Pfirrmann, Toshinori Hoshi, Stefan H. Heinemann
Publikováno v:
Talanta
Methionine oxidation is a reversible post-translational protein modification, affecting protein function, and implicated in aging and degenerative diseases. The detection of accumulating methionine oxidation in living cells or organisms, however, has