Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Toshinobu Kato"'
Autor:
Toshinobu Kato, Masahiro Kimata, Toshikazu Tsuji, Michitaka Shichijo, Masayuki Murata, Toru Miura, Isao Serizawa, Naoki Inagaki, Hiroichi Nagai
Publikováno v:
Allergology International, Vol 51, Iss 3, Pp 197-203 (2002)
Background: Although β-adrenergic receptor agonists inhibit antigen-induced release of histamine, leukotrienes and prostaglandin D2 from human lung fragments, dispersed human lung mast cells and human skin mast cells, subcellular mechanisms for the
Externí odkaz:
https://doaj.org/article/785d8520e9ce48ae9f3049dbb2c30022
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats
Autor:
Mutsuyoshi Matsushita, Hatsue Kobayashi, Toshinobu Kato, Hidenori Iwasaki, Takahiro Hata, Takeshi Ohta, Akira Matsuo
Publikováno v:
The Journal of Veterinary Medical Science
Conventional clinical treatments for allergy management remain suboptimal; new, orally available medications that improve a wide range of allergic signs have been desired. We previously demonstrated that JTE-852, a novel spleen tyrosine kinase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b971a455cc46fb576f618ac48f7cf300
http://europepmc.org/articles/PMC5880827
http://europepmc.org/articles/PMC5880827
Autor:
Takahiro Hata, Akira Matsuo, Hatsue Kobayashi, Mutsuyoshi Matsushita, Hidenori Iwasaki, Toshinobu Kato, Takeshi Ohta
Publikováno v:
Life sciences. 191
Aims Immune and inflammatory responses mediated by immunoglobulin (Ig) G are largely responsible for the pathogenesis of autoimmune diseases. Spleen tyrosine kinase (Syk) plays a pivotal role in the IgG-mediated responses; therefore, Syk has emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae94261426b2dc7c4f0e6655755246f
https://pubmed.ncbi.nlm.nih.gov/29056373
https://pubmed.ncbi.nlm.nih.gov/29056373
Autor:
Akira Matsuo, Takahiro Hata, Naoki Miyagawa, Hidenori Iwasaki, Mutsuyoshi Matsushita, Toshinobu Kato, Hatsue Kobayashi
Publikováno v:
European journal of pharmacology. 801
Mast cells stimulated by immunoglobulin E (IgE)-crosslinking secrete mediators, which are mainly categorized into three groups: granule contents, arachidonate metabolites, and cytokines. These mediators play important roles in pathogenesis of allergi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3909799030963c996f78b30de62b7d2
https://pubmed.ncbi.nlm.nih.gov/28259713
https://pubmed.ncbi.nlm.nih.gov/28259713
Autor:
Masaru Tanaka, Toshinobu Kato, Shibata Tsutomu, Korekiyo Wakitani, Naoki Miyagawa, Hidenori Iwasaki
Publikováno v:
International Immunopharmacology. 8:1848-1853
The antigen-induced immediate airway response (IAR) has been considered a form of bronchoconstriction mainly provoked by histamine and leukotriene C4/D4/E4, which are released by stimulation by antigen-specific IgE. However, the pathophysiological fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c1e6b4c9c26a077f34464c34aca5ef
https://doi.org/10.1016/j.intimp.2008.09.003
https://doi.org/10.1016/j.intimp.2008.09.003
Autor:
Isao Serizawa, Naoki Inagaki, Masahiro Kimata, Michitaka Shichijo, Toshikazu Tsuji, Hiroichi Nagai, Toshinobu Kato, Masayuki Murata, Toru Miura
Publikováno v:
Allergology International, Vol 51, Iss 3, Pp 197-203 (2002)
Background Although β-adrenergic receptor agonists inhibit antigen-induced release of histamine, leukotrienes and prostaglandin D 2 from human lung fragments, dispersed human lung mast cells and human skin mast cells, subcellular mechanisms for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f022f5c49f2361753ef57c84aa4c0c
http://www.sciencedirect.com/science/article/pii/S1323893015313332
http://www.sciencedirect.com/science/article/pii/S1323893015313332
Publikováno v:
Biochemical Pharmacology. 60:589-594
Human cultured mast cells (HCMC) secrete histamine, sulfidoleukotrienes (LTs), and prostaglandin D(2) (PGD(2)), and produce a variety of cytokines after aggregation of high-affinity receptors for IgE (FcepsilonRI). With respect to the mitogen-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c45ad9d521ed5259eec8ae298f95a02
https://doi.org/10.1016/s0006-2952(00)00354-3
https://doi.org/10.1016/s0006-2952(00)00354-3
Autor:
Toshinobu KATO, Takeshi OHTA, Hidenori IWASAKI, Hatsue KOBAYASHI, Akira MATSUO, Takahiro HATA, Mutsuyoshi MATSUSHITA
Publikováno v:
Journal of Veterinary Medical Science; Mar2018, Vol. 80 Issue 3, p465-472, 8p
Autor:
Toshinobu Kato, Masaru Tanaka, Shibata Tsutomu, Korekiyo Wakitani, Naoki Miyagawa, Hidenori Iwasaki
Publikováno v:
Biologicalpharmaceutical bulletin. 32(3)
The pharmacological and pathophysiological characteristics of rat antigen-induced late airway response (LAR) are not yet fully understood. In this study, the pharmacological properties of rat ovalbumin (OVA)-induced LAR and effects of the clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c098a9395d1ea7e741a495b9103c99ef
https://pubmed.ncbi.nlm.nih.gov/19252284
https://pubmed.ncbi.nlm.nih.gov/19252284
Autor:
Toru Miura, Hiroichi Nagai, Toshikazu Tsuji, Toshinobu Kato, Masahiro Kimata, Naoki Inagaki, Isao Serizawa
Publikováno v:
Biologicalpharmaceutical bulletin. 27(10)
In the present study, we examined the inhibitory effects of the beta2-adrenoceptor agonists isoproterenol, salbutamol, fenoterol, and clenbuterol, on the release of chemical mediators from cultured human mast cells after prolonged treatment with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76e8005cf62dcd325d7311c00102a6d
https://pubmed.ncbi.nlm.nih.gov/15467193
https://pubmed.ncbi.nlm.nih.gov/15467193