Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Toshinao Tsuge"'
Autor:
Tsuguru Hatta, Gentoku Noma, Hiroyuki Takase, Ryoji Ozono, Toshinao Tsuge, Hitoshi Minowa, Katsuyuki Ando, Jun Narumi, Soichiro Aoki, Hiroyuki Yoshiikawa, Einosuke Mizuta, Hiroshi Kudo, Takeshi Tana, Takuya Tsuchihashi, Miho Kusaka
Publikováno v:
Journal of Hypertension. 41:e499
Publikováno v:
Arzneimittelforschung. 58:18-23
It is still difficult to manage chronic glomerulonephritis with corticosteroids because of safety concerns, especially for patients with mild symptoms and infants. Therefore, an alternative approach is greatly required. Pemirolast potassium (CAS 1002
Autor:
Yuichi Tanaka, Yukihiko Takeda, Chieko Hamada, Hitoshi Suzuki, Noriyoshi Kobayashi, Yasuhiko Tomino, Satoshi Horikoshi, Katsuhiko Asanuma, Toshinao Tsuge, Yoshio Shimizu, Atsushi Kurusu, Yusuke Suzuki, Hiroaki Io, Isao Ohsawa, Junichiro Nakata, Katsuhiko Takara
Publikováno v:
Journal of Nephrology. 24:756-763
BACKGROUND The long-term antiproteinuric effects of benidipine, a calcium channel blocker (CCB), have not been evaluated in detail in hypertensive patients with chronic kidney disease (CKD). METHODS Benidipine (4 mg/day) was administered to previousl
Autor:
Toshinao Tsuge, Satoshi Horikoshi, Steven N. Emancipator, Yusuke Suzuki, Noriyoshi Kobayashi, Koshi Yamada, Yasuhiko Tomino, Tomomi Ikeda
Publikováno v:
Nephrology Dialysis Transplantation
Background Patients with IgA nephropathy (IgAN) have an increased amount of abnormally O-glycosylated IgA1 in circulation, in glomerular deposits and produced by tissue cells in vitro. Although increased production of Th2 cytokines by peripheral bloo
Autor:
Kunimi Maeda, Yasuhiko Tomino, Satoshi Horikoshi, Atsuko Maeda, Toshinao Tsuge, Tomohito Gohda
Publikováno v:
Cell Biology International. 29:422-428
The peroxisome proliferator-activated receptor (PPAR)γ is expressed not only in adipose tissue but also in macrophages/monocytes and plays important roles in acute/chronic inflammation. Transforming growth factor (TGF)-β is a common pathogenic indi
Autor:
Toshinao Tsuge, Tomohito Gohda, Yasuhiko Tomino, Leyi Gu, Mitsuo Tanimoto, Satoshi Horikoshi, Yusuke Suzuki
Publikováno v:
Kidney International. 67:S92-S95
Renal fibrosis/sclerosis is the common final pathway leading to end-stage renal failure. The renal fibrosis/sclerosis is characterized by increased proliferation of fibroblasts and excessive accumulation of extracellular matrix (ECM). The severity of
Autor:
Toshinao Tsuge, Ivan C. Moura, Marc Benhamou, Pierre Launay, Max D. Cooper, Elie Haddad, Renato C. Monteiro, Michelle Arcos-Fajardo
Publikováno v:
Trends in Molecular Medicine. 8:464-468
IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, frequently progresses to renal failure. The pathogenesis of this disease involves the deposition of undergalactosylated IgA1 complexes in the glomerular mesangium. How the
Publikováno v:
American Journal of Physiology-Renal Physiology. 282:F358-F365
In the kidney, proteins filtered through glomeruli are reabsorbed by endocytosis along the proximal tubules to avoid renal loss of large amounts of proteins. Recently, neonatal Fc receptor (FcRn), which is involved in the transport of IgG across seve
Autor:
Toshinao Tsuge, Yasuhiko Tomino
Publikováno v:
Hong Kong Journal of Nephrology. 2:68-73
Among the developmental and/or exacerbating factors of IgA nephropathy, cytokines have been found to play a role in the progression of the disease. We previously reported that the levels of urinary IL-6, monocyte chemoattractant protein (MCP)-1, and
Autor:
Toshinao Tsuge
Publikováno v:
Juntendo Medical Journal. 45:575-583