Zobrazeno 1 - 10 of 837 pro vyhledávání: '"Toshimoto K"'
1
Akademický článek
Beyond the basics: A deep dive into parameter estimation for advanced PBPK and QSP models.
Autor: Toshimoto K; Systems Pharmacology, Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., Ibaraki, Japan. Electronic address: kota.toshimoto@astellas.com.
Publikováno v: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2024 Jun; Vol. 56, pp. 101011. Date of Electronic Publication: 2024 Mar 26.
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2
Akademický článek
Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncology.
Autor: Oishi M; Systems Pharmacology, Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., Tsukuba, Ibaraki, 305-8585, Japan. Electronic address: masayo.oishi@astellas.com., Sayama H; Systems Pharmacology, Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., Tsukuba, Ibaraki, 305-8585, Japan., Toshimoto K; Systems Pharmacology, Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., Tsukuba, Ibaraki, 305-8585, Japan., Nakayama T; Systems Pharmacology, Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., Tsukuba, Ibaraki, 305-8585, Japan., Nagasaka Y; Non-Clinical Biomedical Science, Applied Research & Operations, Astellas Pharma Inc., Tsukuba, Ibaraki, 305-8585, Japan.
Publikováno v: Drug metabolism and pharmacokinetics [Drug Metab Pharmacokinet] 2024 Jun; Vol. 56, pp. 101020. Date of Electronic Publication: 2024 May 09.
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3
Akademický článek
Physiologically-based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B.
Autor: Nakayama S; DMPK Research Laboratories, Shoyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan., Toshimoto K; Systems Pharmacology, Non-Clinical Biomedical Science, Applied Research and Operations, Astellas Pharma Inc., Ibaraki, Japan.; Sugiyama Laboratory, RIKEN Cluster for Science, RIKEN, Yokohama, Kanagawa, Japan., Yamazaki S; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, LLC, San Diego, California, USA., Snoeys J; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, Beerse, Belgium., Sugiyama Y; Sugiyama Laboratory, RIKEN Cluster for Science, RIKEN, Yokohama, Kanagawa, Japan.; Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Josai International University (JIU), Tokyo, Japan.
Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Oct; Vol. 12 (10), pp. 1461-1472. Date of Electronic Publication: 2023 Sep 04.
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4
Akademický článek
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy.
Autor: Koyama S; Sugiyama Laboratory, RIKEN Cluster for Science, Technology and Innovation Hub, Yokohama, Kanagawa, Japan (S.K., K.T., Y.S.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul, Korea (W.L.); and National Institute of Informatics, Chiyoda-ku, Tokyo, Japan (Y.A.)., Toshimoto K; Sugiyama Laboratory, RIKEN Cluster for Science, Technology and Innovation Hub, Yokohama, Kanagawa, Japan (S.K., K.T., Y.S.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul, Korea (W.L.); and National Institute of Informatics, Chiyoda-ku, Tokyo, Japan (Y.A.)., Lee W; Sugiyama Laboratory, RIKEN Cluster for Science, Technology and Innovation Hub, Yokohama, Kanagawa, Japan (S.K., K.T., Y.S.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul, Korea (W.L.); and National Institute of Informatics, Chiyoda-ku, Tokyo, Japan (Y.A.)., Aoki Y; Sugiyama Laboratory, RIKEN Cluster for Science, Technology and Innovation Hub, Yokohama, Kanagawa, Japan (S.K., K.T., Y.S.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul, Korea (W.L.); and National Institute of Informatics, Chiyoda-ku, Tokyo, Japan (Y.A.)., Sugiyama Y; Sugiyama Laboratory, RIKEN Cluster for Science, Technology and Innovation Hub, Yokohama, Kanagawa, Japan (S.K., K.T., Y.S.); College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul, Korea (W.L.); and National Institute of Informatics, Chiyoda-ku, Tokyo, Japan (Y.A.) ychi.sugiyama@riken.jp.
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2021 Apr; Vol. 49 (4), pp. 298-304. Date of Electronic Publication: 2021 Feb 08.
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5
Akademický článek
Engineering a vanillate-producing strain of Pseudomonas sp. NGC7 corresponding to aromatic compounds derived from the continuous catalytic alkaline oxidation of sulfite lignin.
Autor: Kamada, Mami1 (AUTHOR), Yasuta, Chieko1 (AUTHOR), Higuchi, Yudai1 (AUTHOR), Yoshida, Akihiro2 (AUTHOR), Kurnia, Irwan3 (AUTHOR), Sakamoto, Chiho1 (AUTHOR), Takeuchi, Aya4 (AUTHOR), Osaka, Yuta2 (AUTHOR), Muraki, Kanami1 (AUTHOR), Kamimura, Naofumi4 (AUTHOR), Masai, Eiji4 (AUTHOR), Sonoki, Tomonori1 (AUTHOR) sonoki@hirosaki-u.ac.jp
Publikováno v: Microbial Cell Factories. 11/19/2024, Vol. 23 Issue 1, p1-12. 12p.
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6
Akademický článek
Chromosome level assemblies of Nakaseomyces (Candida) bracarensis uncover two distinct clades and define its adhesin repertoire.
Autor: Marcet-Houben, Marina1,2,3 (AUTHOR), Księżopolska, Ewa1,2,3 (AUTHOR), Gabaldón, Toni1,2,3,4 (AUTHOR) toni.gabaldon@bsc.es
Publikováno v: BMC Genomics. 11/7/2024, Vol. 25 Issue 1, p1-13. 13p.
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7
Akademický článek
Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework.
Autor: Karkhanis, Aneesh V.1 (AUTHOR) aneesh.karkhanis@certara.com, Harwood, Matthew D.1 (AUTHOR), Stader, Felix1 (AUTHOR), Bois, Frederic Y.1 (AUTHOR), Neuhoff, Sibylle1 (AUTHOR)
Publikováno v: Pharmaceutics. Oct2024, Vol. 16 Issue 10, p1284. 22p.
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8
Akademický článek
Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss–Newton method.
Autor: Nakamura, Ryo1,2 (AUTHOR), Yoshikado, Takashi1 (AUTHOR) takashi.yoshikado@yok.hamayaku.ac.jp, Aoki, Yasunori3 (AUTHOR), Sugiyama, Yuichi3,4 (AUTHOR), Chiba, Koji1 (AUTHOR)
Publikováno v: CTS: Clinical & Translational Science. Oct2024, Vol. 17 Issue 10, p1-14. 14p.
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9
Akademický článek
A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation.
Autor: Tomaru A; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan., Toshimoto K; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan., Lee W; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea., Ishigame K; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan., Sugiyama Y; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, Technology and Innovation Hub, RIKEN, Yokohama, Kanagawa, Japan. Electronic address: ychi.sugiyama@riken.jp.
Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2021 Jan; Vol. 110 (1), pp. 510-516. Date of Electronic Publication: 2020 Nov 01.
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10
Akademický článek
Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B.
Autor: Park JE; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan; Pharmacokinetics, Dynamics and Metabolism, Translational Medicine and Early Development, R&D, Sanofi K.K., 3 Chome-20-2, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Shitara Y; Pharmacokinetics, Dynamics and Metabolism, Translational Medicine and Early Development, R&D, Sanofi K.K., 3 Chome-20-2, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Lee W; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Bldg 21 Rm 309, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, S. Korea., Morita S; Pharmacokinetics, Dynamics and Metabolism, Translational Medicine and Early Development, R&D, Sanofi K.K., 3 Chome-20-2, Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Sahi J; Pharmacokinetics, Dynamics and Metabolism, Translational Medicine and Early Development, R&D, Sanofi China, 1228 Yan'an Middle Road, Jing'an District, Shanghai, China., Toshimoto K; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan., Sugiyama Y; Sugiyama Laboratory, RIKEN Baton Zone Program, RIKEN Cluster for Science, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address: ychi.sugiyama@riken.jp.
Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2021 Jan; Vol. 110 (1), pp. 517-528. Date of Electronic Publication: 2020 Oct 13.
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