Výsledky vyhledávání - "Toshimori Inaba"

A novel compound, R-138329, increases plasma HDL cholesterol via inhibition of scavenger receptor BI-mediated selective lipid uptake

Autor: Koji Abe, Minoru Uchiyama, Ken Kitayama, Tomiichiro Oda, Yoshiya Amemiya, Tomohiro Nishizawa, Naoko Ubukata, Kenji Wakabayashi, Toshimori Inaba, Makiko Yamada

Publikováno v: Atherosclerosis. 194:300-308

High-density lipoprotein (HDL) has a protective effect against atherosclerosis. Therefore, a compound that elevates the plasma HDL cholesterol (HDL-C) levels is expected to be a promising anti-atherosclerotic agent. We discovered a novel compound, R-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e252dc324aae98bba6bda98d184880ab
https://doi.org/10.1016/j.atherosclerosis.2006.10.025

Zobrazit plný text záznamu

ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice

Autor: Naoki Terasaka, Ken Kitayama, Tadashi Koieyama, Tatsuo Tanimoto, Atsuhiro Miyazaki, Kayoko Ito, Naoyuki Maeda, Naoko Ubukata, Toshimori Inaba, Naomi Kasanuki

Publikováno v: Atherosclerosis. 190:239-247

The objective of the present study was to determine whether a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, pactimibe sulfate (CS-505), could reduce atherosclerotic lesions beyond and independent of the reduction achieved by cholestero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a7131240ee6f9b695b7207ca82743f
https://doi.org/10.1016/j.atherosclerosis.2006.03.007

Zobrazit plný text záznamu

Blockade of scavenger receptor class B type I raises high density lipoprotein cholesterol levels but exacerbates atherosclerotic lesion formation in apolipoprotein E deficient mice

Autor: Kenji Wakabayashi, Toshimori Inaba, Koji Abe, Yoshiya Amemiya, Tomiichiro Oda, Tomohiro Nishizawa, Ken Kitayama

Publikováno v: Journal of Pharmacy and Pharmacology. 58:1629-1638

Recent accumulating evidence supports the concept that raising high-density lipoprotein (HDL) may represent an additional therapeutic target for prevention of cardiovascular disease. Scavenger receptor class B type I plays a critical role in plasma H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b22e3300abab497d578f4a2be2adeef
https://doi.org/10.1211/jpp.58.12.0010

Zobrazit plný text záznamu

Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe

Autor: Tatsuo Tanimoto, Tomoyuki Fujioka, Teiichiro Koga, Naoki Terasaka, Ken Kitayama, Toshimori Inaba

Publikováno v: European Journal of Pharmacology. 540:121-130

Pactimibe sulfate, [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate, a novel Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor, was investigated in vitro and in vivo to characterize its potential. Pacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1604f2e4c1c0025073dd7108dd24e1f2
https://doi.org/10.1016/j.ejphar.2006.04.022

Zobrazit plný text záznamu

Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys

Autor: Hitoshi Kurata, Daisuke Nakai, Elly de Wit, Keita Kono, Takafumi Kohama, Arthur Gerritsen van der Hoop, Louis H. Cohen, Ken Kitayama, Toshimori Inaba

Publikováno v: European Journal of Pharmacology, 1-2, 539, 89-98

1-{7-[(1-(3,5-Diethoxyphenyl)-3-{[(3,5-difluorophenyl)(ethyl)amino]carbo nyl}-4-oxo-1,4-dihydroquinolin-7-yl)oxy]heptyl}-1-methylpiperidinium bromide, R-146224, is a potent, specific ileum apical sodium-dependent bile acid transporter (ASBT) inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ce39e9ca5781489a9eb38342fd37b4
https://doi.org/10.1016/j.ejphar.2006.04.005

Zobrazit plný text záznamu

Effect of Combined Treatment With an Angiotensin II Receptor Antagonist and an HMG-CoA Reductase Inhibitor on Atherosclerosis in Genetically Hyperlipidemic Rabbits

Autor: Toshimori Inaba, Ken Kitayama, Toshio Sada, Mikio Kato, Hiroyuki Koike, Makoto Mizuno

Publikováno v: Journal of Cardiovascular Pharmacology. 46:556-562

The purpose of this study was to examine whether coadministration of olmesartan medoxomil (OLM), an AT1 subtype specific angiotensin II receptor blocker (ARB), and pravastatin (PRV), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f063f9efa3b63c17ad070a1ea36d79f5
https://doi.org/10.1097/01.fjc.0000179434.18750.28

Zobrazit plný text záznamu

Liver X receptor agonists inhibit tissue factor expression in macrophages

Autor: Toshimori Inaba, Akiko Ariga, Toshihiko Fujiwara, Naoki Terasaka, Tadashi Koieyama, Ayano Hiroshima, Shoko Honzumi

Publikováno v: FEBS Journal. 272:1546-1556

Exposure of blood to tissue factor (TF) rapidly initiates the coagulation serine protease cascades. TF is expressed by macrophages and other types of cell within atherosclerotic lesions and plays an important role in thrombus formation after plaque r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed2a754c5b08760189021cd702a08900
https://doi.org/10.1111/j.1742-4658.2005.04599.x

Zobrazit plný text záznamu

Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

Autor: Iichiro Shimomura, Naohiko Sakai, Hideki Kobayashi, Noriyuki Ouchi, Toshimori Inaba, Koji Ohashi, Shinji Kihara, Tohru Funahashi, Yukio Arita, Masahiro Kumada, Yoshihisa Okamoto, Naoki Terasaka, Yuji Matsuzawa, Makoto Nishida

Publikováno v: Circulation. 106:2767-2770

Background— Dysregulation of adipocyte-derived bioactive molecules plays an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the injured artery from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca137c245d77eb4a3f8af87d51b1eac0
https://doi.org/10.1161/01.cir.0000042707.50032.19

Zobrazit plný text záznamu

T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice

Autor: Toshimori Inaba, Ayano Hiroshima, Daisuke Nakai, Tadashi Koieyama, Naoki Terasaka, Yuka Morikawa, Naoko Ubukata

Publikováno v: FEBS Letters. 536:6-11

Liver X receptors (LXR alpha and LXR beta) are nuclear receptors, which are important regulators of cholesterol and lipid metabolism. LXRs control genes involved in cholesterol efflux in macrophages, bile acid synthesis in liver and intestinal choles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bddf87df6bfc4871ddab7b5c34e5c2
https://doi.org/10.1016/s0014-5793(02)03578-0

Zobrazit plný text záznamu

Skipping of Exon 14 and Possible Instability of Both the mRNA and the Resultant Truncated Protein Underlie a Common Cholesteryl Ester Transfer Protein Deficiency in Japan

Autor: Nobuhiro Yamada, Tamio Teramoto, Jun-ichi Osuga, Makoto Kinoshita, Kenji Harada, Yoshio Yazaki, Takanari Gotoda, Toshimori Inaba, Shun Ishibashi, Masako Shimada

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 17:1376-1381

Abstract Among the Japanese population, a G-to-A mutation at the beginning of intron 14 of the human cholesteryl ester transfer protein (CETP) gene is a frequent cause of CETP deficiency characterized by markedly increased HDL cholesterol. The result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6521a1b5443047ca1d8c998c8f78a1
https://doi.org/10.1161/01.atv.17.7.1376

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání