Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Toshimitsu Uenaka"'
Autor:
Hitomi Sakai, Hisato Kawakami, Takeshi Teramura, Yuta Onodera, Elizabeth Somers, Keiji Furuuchi, Toshimitsu Uenaka, Ryoji Kato, Kazuhiko Nakagawa
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Abstract Background The main function of folate receptor α (FOLRα) has been considered to mediate intracellular folate uptake and induce tumor cell proliferation. Given the broad spectrum of expression among malignant tumors, including gastric canc
Externí odkaz:
https://doaj.org/article/123305652e1b46c1a6de16796002c111
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ead92a929cc4e895624b9120695df
https://doi.org/10.1158/1535-7163.22499889.v1
https://doi.org/10.1158/1535-7163.22499889.v1
Autor:
Earl F. Albone, Luigi Grasso, Toshimitsu Uenaka, Frank Fang, Keiji Furuuchi, Megan Kuc, Danielle Fernando, Shawn Fernando, Katherine A. Rybinski, Christopher J. Maddage, Arielle C. Verdi, Andrew Z. Milinichik, Utpal Majumder, Keigo Tanaka, Jing Li, Xin Cheng
Microtubule-targeting agents (MTA) have been investigated for many years as payloads for antibody–drug conjugates (ADC). In many cases, these ADCs have shown limited benefits due to lack of efficacy or significant toxicity, which has spurred contin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568f92c858fd241091aa4a5827363206
https://doi.org/10.1158/1535-7163.c.6537841.v1
https://doi.org/10.1158/1535-7163.c.6537841.v1
Autor:
Earl F. Albone, Luigi Grasso, Toshimitsu Uenaka, Frank Fang, Keiji Furuuchi, Megan Kuc, Danielle Fernando, Shawn Fernando, Katherine A. Rybinski, Christopher J. Maddage, Arielle C. Verdi, Andrew Z. Milinichik, Utpal Majumder, Keigo Tanaka, Jing Li, Xin Cheng
Specificity of MORAb-202 cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f83f03398bd9719a130f22d1e871f77
https://doi.org/10.1158/1535-7163.22504744.v1
https://doi.org/10.1158/1535-7163.22504744.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Figure S1. Synthesis of [3H]apratoxin A. Figure S2. Synthesis of C.18-epi-apratoxin A. Figure S3. Apratoxin A in vitro IC50 against panels of human cancer cell lines. Table S1. Summary table for in vivo efficacy studies. Figure S4. Apratoxin A concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c65eb6f8b62874049a2fbbb2e9b798
https://doi.org/10.1158/1535-7163.22504099.v1
https://doi.org/10.1158/1535-7163.22504099.v1
Autor:
Seiji Yano, Toshimitsu Uenaka, Yoshitaka Sekido, Tetsuya Mitsudomi, Kenichi Suda, Kunio Matsumoto, Takahiro Nakamura, Kenji Kita, Takako Sano, Daisuke Ishikawa, Shigeki Nanjo, Tadaaki Yamada, Shinji Takeuchi, Takayuki Nakagawa
PDF file, 73K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02df66955cdffa281516cdbf3548fcb8
https://doi.org/10.1158/1535-7163.22499508
https://doi.org/10.1158/1535-7163.22499508
Autor:
Akihiko Tsuruoka, Toshimitsu Uenaka, Masao Iwata, Junji Matsui, Tomohiro Matsushima, Toshimi Okada, Yoshinobu Yamane, Isao Ohashi, Yuki Karoji, Yusuke Nakatani, Yukinori Minoshima, Kiyoshi Okamoto, Naoko Hata Sugi, Satoshi Nagao, Setsuo Funasaka, Hiroko Kuramochi, Takayuki Nakagawa, Masaki Mikamoto, Yukiko Miyajima, Kotaro Kodama, Yuji Yamamoto, Saori Watanabe Miyano
IC50 values for the inhibition of 93 human kinases by E7090.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727d71c17112f88bd1dc928969d95751
https://doi.org/10.1158/1535-7163.22506370
https://doi.org/10.1158/1535-7163.22506370
Autor:
Akihiko Tsuruoka, Toshimitsu Uenaka, Masao Iwata, Junji Matsui, Tomohiro Matsushima, Toshimi Okada, Yoshinobu Yamane, Isao Ohashi, Yuki Karoji, Yusuke Nakatani, Yukinori Minoshima, Kiyoshi Okamoto, Naoko Hata Sugi, Satoshi Nagao, Setsuo Funasaka, Hiroko Kuramochi, Takayuki Nakagawa, Masaki Mikamoto, Yukiko Miyajima, Kotaro Kodama, Yuji Yamamoto, Saori Watanabe Miyano
Western blot analysis of FGFR1 in human lung cancer cell lines harboring FGFR1 amplifications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0cbd7b4c4157ac6029645427248557
https://doi.org/10.1158/1535-7163.22506373
https://doi.org/10.1158/1535-7163.22506373
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 811K, Fig. S1. Effects of EPZ-6438 on Gene Promoter H3K27 Methylation, Recruitment of PRC2 Components to Gene Promoters, and Cell Cycle, in WSU-DLCL2 Cells. Fig. S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fcbfa5d3e9bdddeac3c8f600a70bce
https://doi.org/10.1158/1535-7163.22499898.v1
https://doi.org/10.1158/1535-7163.22499898.v1
Autor:
Kenichi Nomoto, Mary Woodall-Jappe, Toshimitsu Uenaka, William H. Gerwick, Yoshihiko Kotake, Hajime Shimizu, Xiaojie Zhu, Hyeong-wook Choi, Steven Mathieu, Kuo-Ming Wu, Yongchun Shen, Karen Tendyke, Sergei Agoulnik, Krista Condon, Donna Kolber-Simonds, Sandeep Akare, Yimin Jiang, Zhihong Chen, Kuan-Chun Huang
Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo. Previous mechanistic studies have suggested it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702da5e1eb71b2ce4a697dd456e12e0
https://doi.org/10.1158/1535-7163.c.6537622.v1
https://doi.org/10.1158/1535-7163.c.6537622.v1