Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Toshimichi Nakamura"'
Autor:
Toshimichi Nakamura, Kota Toshimoto, Wooin Lee, Chiyo K. Imamura, Yusuke Tanigawara, Yuichi Sugiyama
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 474-482 (2018)
The Tamoxifen Response by CYP2D6 Genotype‐based Treatment‐1 (TARGET‐1) study (n = 180) was conducted from 2012–2017 in Japan to determine the efficacy of tamoxifen dosing guided by cytochrome P450 2D6 (CYP2D6) genotypes. To predict its outcom
Externí odkaz:
https://doaj.org/article/d321e969e1c84baea31b14f8378e3959
Autor:
Wooin Lee, Kota Toshimoto, Chiyo K. Imamura, Toshimichi Nakamura, Yuichi Sugiyama, Yusuke Tanigawara
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 474-482 (2018)
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 474-482 (2018)
The Tamoxifen Response by CYP2D6 Genotype-based Treatment-1 (TARGET-1) study (n = 180) was conducted from 2012-2017 in Japan to determine the efficacy of tamoxifen dosing guided by cytochrome P450 2D6 (CYP2D6) genotypes. To predict its outcomes prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9035c9e4174303b75f6fe245423d04
http://europepmc.org/articles/PMC6063740
http://europepmc.org/articles/PMC6063740
Publikováno v:
J Pharmacol Exp Ther
Methylprednisolone (MPL), a corticosteroid of intermediate potency, remains an important immunomodulatory agent for autoimmune diseases. Although sex differences in corticosteroid pharmacokinetics/pharmacodynamics (PK/PD) have been documented in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ec387959723f492f6b217b4732f495
https://europepmc.org/articles/PMC7184193/
https://europepmc.org/articles/PMC7184193/
Autor:
Toshimichi Nakamura, Ikumi Tamai, Naoki Ishiguro, Ryohei Fujiwara, Tomoji Maeda, Masanobu Oyabu, Takeo Nakanishi, Yoshiyuki Shirasaka
Publikováno v:
Biological and Pharmaceutical Bulletin. 33:691-696
Phosphatidylcholine (PC) production is accelerated by glucocorticoid, such as dexamethasone (DEX), which enhances fetal lung maturation, promotes differentiation of alveolar type II (ATII) cells, and increases production of both lipid and protein com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1855da0ce9349de998d06cc301ce96c
https://doi.org/10.1248/bpb.33.691
https://doi.org/10.1248/bpb.33.691
Autor:
Akimasa Fukushi, Ikumi Tamai, Masanobu Sato, Keisuke Mitsuoka, Toshimichi Nakamura, Yoshiyuki Shirasaka, Takeo Nakanishi
Publikováno v:
Biopharmaceutics & Drug Disposition. 30:126-137
L-Citrulline has diagnostic potential for renal function, because its plasma concentration increases with the progression of renal failure. Although L-citrulline extracted by glomerular filtration in kidney is mostly reabsorbed, the mechanism involve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7dc1075544dc4e2b70aaab10a3a2b3
https://doi.org/10.1002/bdd.653
https://doi.org/10.1002/bdd.653
Autor:
Ikumi Tamai, Tomoji Maeda, Hikaru Yabuuchi, Daisuke Kobayashi, Shin Aizawa, Kenji Yoshida, Shigeki Sugiura, Toshimichi Nakamura
Publikováno v:
Pharmaceutical Research. 24:1628-1635
Recently, it was reported that OCTN1 transporter (SLC22A4) is associated with rheumatoid arthritis (RA) and Crohn's disease. Additionally, we reported that OCTN1 is expressed in hematopoietic cells, preferentially in erythroid cells. Accordingly, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089d5f2c0360564d80e43908cce7d4f8
https://doi.org/10.1007/s11095-007-9290-8
https://doi.org/10.1007/s11095-007-9290-8
Autor:
Takeo Nakanishi, John P. Keogh, Ikumi Tamai, Yoshiyuki Shirasaka, Toshimichi Nakamura, Tsunemitsu Haruta
Publikováno v:
Molecular pharmaceutics. 7(1)
Ipratropium bromide, an anticholinergic drug used for the treatment of asthma and chronic obstructive pulmonary disease, has low oral bioavailability, but systemic exposure, superior to oral administration, can be achieved by inhalation. Therefore, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa568b5c6120580a4355978dd2ed32e3
https://pubmed.ncbi.nlm.nih.gov/20020740
https://pubmed.ncbi.nlm.nih.gov/20020740
Autor:
Toshimichi Nakamura, Shigeki Sugiura, Daisuke Kobayashi, Kenji Yoshida, Hikaru Yabuuchi, Shin Aizawa, Tomoji Maeda, Ikumi Tamai
Publikováno v:
Pharmaceutical Research; Sep2007, Vol. 24 Issue 9, p1628-1635, 8p