Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Toshikuni, Sasaoka"'
Autor:
Runa Hirayama, Hiroaki Taketsuru, Ena Nakatsukasa, Rie Natsume, Nae Saito, Shuko Adachi, Sayaka Kuwabara, Jun Miyamoto, Shiori Miura, Nobuyoshi Fujisawa, Yoshitaka Maeda, Keizo Takao, Manabu Abe, Toshikuni Sasaoka, Kenji Sakimura
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The common marmoset (Callithrix jacchus) has attracted attention as a valuable primate model for the analysis of human diseases. Despite the potential for primate genetic modification, however, its widespread lab usage has been limited due t
Externí odkaz:
https://doaj.org/article/2b492948c1b24bdb957e5f9b571aecc3
Autor:
Ryota Kai, Kuniyuki Takahashi, Kazuki Tainaka, Yuriko Iwakura, Hisaaki Namba, Nae Saito, Toshikuni Sasaoka, Shun Yamaguchi, Hiroyuki Nawa, Arata Horii
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Posture and gait are maintained by sensory inputs from the vestibular, visual, and somatosensory systems and motor outputs. Upon vestibular damage, the visual and/or somatosensory systems functionally substitute by cortical mechanisms called
Externí odkaz:
https://doaj.org/article/c1bb079a795c46599bf7137684ad31df
Autor:
Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, Kuniyuki Kano, Junken Aoki, Goro Katsuumi, Masayoshi Suda, Kazuyuki Ozaki, Yutaka Yoshida, Shujiro Okuda, Shigeo Ohta, Shiki Okamoto, Yasuhiko Minokoshi, Kanako Oda, Toshikuni Sasaoka, Manabu Abe, Kenji Sakimura, Yoshiaki Kubota, Norihiko Yoshimura, Shingo Kajimura, Maria Zuriaga, Kenneth Walsh, Tomoyoshi Soga, Tohru Minamino
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Low body temperature predicts a poor outcome in patients with heart failure, but the underlying pathological mechanisms and implications are largely unknown. Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and
Externí odkaz:
https://doaj.org/article/47e7cf28377a4d3a94aefb37d6721e18
Autor:
Toshiya Sato, Kanako Oda, Seiko Sakai, Rika Kato, Saori Yamamori, Makoto Itakura, Yoshio Kodera, Masatoyo Nishizawa, Toshikuni Sasaoka, Osamu Onodera, Minesuke Yokoyama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract TAR DNA-binding protein 43 kDa (TDP-43), a nuclear protein, plays an important role in the molecular pathogenesis of amyotrophic lateral sclerosis (ALS). The long-disordered C-terminal region (CTR) of TDP-43 is known to be aggregation-prone
Externí odkaz:
https://doaj.org/article/419759e22ee04f0e92a2be83c4e71e34
Autor:
Nanaho Fukuda, Tomoyuki Fukuda, Piergiorgio Percipalle, Kanako Oda, Nobuyuki Takei, Kevin Czaplinski, Kazushige Touhara, Yoshihiro Yoshihara, Toshikuni Sasaoka
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112398- (2023)
Summary: Spatiotemporal control of gene expression is important for neural development and function. Here, we show that heterogeneous nuclear ribonucleoprotein (hnRNP) A/B is highly expressed in developing olfactory sensory neurons (OSNs), and its kn
Externí odkaz:
https://doaj.org/article/ff0287948e0248f8865a9a3d74cb6ad4
Autor:
Nanxi Liu, Atsuhiko Iijima, Yutaka Iwata, Kento Ohashi, Nobuyoshi Fujisawa, Toshikuni Sasaoka, Isao Hasegawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract When writing an object’s name, humans mentally construct its spelling. This capacity critically depends on use of the dual-structured linguistic system, in which meaningful words are represented by combinations of meaningless letters. Here
Externí odkaz:
https://doaj.org/article/875028724bf644faad677970e17b3bff
Autor:
Amy Cheung, Kotaro Konno, Yuka Imamura, Aya Matsui, Manabu Abe, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Masahiko Watanabe, Kensuke Futai
Publikováno v:
eLife, Vol 12 (2023)
Extensive serotonin (5-hydroxytryptamine, 5-HT) innervation throughout the brain corroborates 5-HT’s modulatory role in numerous cognitive activities. Volume transmission is the major mode for 5-HT transmission but mechanisms underlying 5-HT signal
Externí odkaz:
https://doaj.org/article/4868a911a672491985c4f12c4908558e
Autor:
Toshihiro Yamaguchi, Tomokazu S. Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E. Sweet, Atsushi Sanbe, Kenji Yoshimi, Ichiro Manabe, Toshikuni Sasaoka, Matthew R. G. Taylor, Haruhiro Toko, Eiki Takimoto, Atsuhiko T. Naito, Issei Komuro
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The pathophysiological role of dopamine D1 receptor (D1R) in chronic heart failure remains elusive. Here the authors show that D1R-expressing cardiomyocytes appear in chronic heart failure and play a pivotal role in triggering lethal ventricular arrh
Externí odkaz:
https://doaj.org/article/59249ab8e1b144e4814231c3afc24f46
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) is considered to play an important role not only in reward-based learning but also in aversive learning. The contextual and auditory cued fear conditioning tests involve the processing o
Externí odkaz:
https://doaj.org/article/2e306e26c3cb42049245b14a649fc606
Autor:
Qingsong Ran, Qiliang Zhou, Kanako Oda, Akihiro Yasue, Manabu Abe, Xulu Ye, Yingchun Li, Toshikuni Sasaoka, Kenji Sakimura, Yoichi Ajioka, Yasuo Saijo
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The generation of mature, functional, thyroid follicular cells from pluripotent stem cells would potentially provide a therapeutic benefit for patients with hypothyroidism, but in vitro differentiation remains difficult. We earlier reported the in vi
Externí odkaz:
https://doaj.org/article/3e63c86498fa41d9af0175cc5f7db864