Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Toshiko Sakihama"'
Autor:
Hideki Kakutani, Azusa Takahashi, Masuo Kondoh, Yumiko Saito, Toshiaki Yamaura, Toshiko Sakihama, Takao Hamakubo, Kiyohito Yagi
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16611 (2011)
Recent progress in cell biology has provided new insight into the claudin (CL) family of integral membrane proteins, which contains more than 20 members, as a target for pharmaceutical therapy. Few ligands for CL have been identified because it is di
Externí odkaz:
https://doaj.org/article/5ca5dbfedf3a4ab3b2269f34f694d66e
Autor:
Toshiko Sakihama, Takato Sato, Hiroko Iwanari, Toshio Kitamura, Shimon Sakaguchi, Tatsuhiko Kodama, Takao Hamakubo
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4024 (2008)
BACKGROUND: Membrane protein interactions play an important role in cell-to-cell recognition in various biological activities such as in the immune or neural system. Nevertheless, there has remained the major obstacle of expression of the membrane pr
Externí odkaz:
https://doaj.org/article/0060a15c5e014846bc9f485a54370127
Autor:
Masato Yasui, Hiroko Iwanari, Takao Hamakubo, Jing-Yan Han, Osamu Kusano-Arai, Julia Ramadhanti, Toshiko Sakihama, Kazuo Fujihara, Ping Huang, Masashi Aoki, Takayuki Miyauchi, Yoichiro Abe, Yoshiki Takai
Publikováno v:
Biochemistry and Biophysics Reports
Neuromyelitis optica (NMO), an autoimmune disease of the central nervous system, is characterized by an autoantibody called NMO-IgG that recognizes the extracellular domains (ECDs) of aquaporin-4 (AQP4). In this study, monoclonal antibodies (mAbs) ag
Autor:
Katsuyuki Mitomo, Ping Huang, Takao Hamakubo, Masato Yasui, Kaori Miyazaki-Komine, Yoshiki Takai, Katsushi Koda, Toshiko Sakihama, Yoichiro Abe, Hiroko Iwanari, Yoshiaki Toyama, Tatsuro Misu, Osamu Kusano-Arai, Kazuo Fujihara
Publikováno v:
British Journal of Pharmacology. 173:103-114
Background and Purpose Most of the cases of neuromyelitis optica (NMO) are characterized by the presence of an autoantibody, NMO-IgG, which recognizes the extracellular domains of the water channel, aquaporin-4. Binding of NMO-IgG to aquaporin-4 expr
Autor:
Toshiko Sakihama, Takao Hamakubo, Hiroko Iwanari, Tasturo Misu, Kazuo Fujihara, Masato Yasui, Osamu Kusano-Arai, Ping Huang, Julia Ramadhanti, Yoichiro Abe
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32:270-276
Aquaporin-4 (AQP4), the most abundant water channel in the brain, plays a central role in water homeostasis, neuronal activity, and migration of astrocytes in the central nervous system. Recent studies have demonstrated that AQP4 is a target of an au
Autor:
Toshiko Sakihama, Hiroshi Hamana, Takao Hamakubo, Kazuaki Takahashi, Rie Fukuda, Takaaki Sato, Kenichi Mitsui, Kazuyuki Masuda
Publikováno v:
Chemical Senses. 37:837-847
Despite that recent progress in genomics has elucidated the genomic structure of the olfactory receptors (ORs), most of them are still orphan receptors. The low expression level of ORs in heterologous cells has hampered many attempts to establish cel
Autor:
Tohru Kozasa, Masayuki Suzuki, Tatsuhiko Kodama, Kazuyuki Masuda, Motoyoshi Baba, Takao Hamakubo, Hiroto Kuroda, Tsuneyuki Ozaki, Rashid A. Ganeev, Masahiro Hayashi, Toshiko Sakihama
Publikováno v:
Journal of Luminescence. 127:355-361
We improved an ultrafast time-resolved fluorescence resonance energy transfer (FRET) spectroscopy system and measured directly the decrease in the fluorescence decay time of the FRET signal, without any entanglement of components in the picosecond ti
Autor:
Siamon Gordon, Keiji Hirota, Takashi Nomura, Shizuo Akira, Shimon Sakaguchi, Toshiko Sakihama, Ichiro Miki, Gordon D. Brown, Hiroyuki Yoshitomi, Satoshi Tanaka, Noriko Sakaguchi, Takashi Nakamura, Tomoyuki Tagami, Katsuya Kobayashi
Publikováno v:
The Journal of Experimental Medicine
A combination of genetic and environmental factors can cause autoimmune disease in animals. SKG mice, which are genetically prone to develop autoimmune arthritis, fail to develop the disease under a microbially clean condition, despite active thymic
Publikováno v:
International Immunology. 16:1189-1201
Naturally arising CD25(+)CD4(+) regulatory T (T(R)) cells can be exploited to establish immunologic tolerance to non-self antigens. In vivo exposure of CD25(+)CD4(+) T cells from normal naive mice to alloantigen in a T cell-deficient environment elic
Autor:
Takeshi Takahashi, Toshiko Sakihama, Noriko Sakaguchi, Sayuri Yamazaki, Takashi Nomura, Takaji Matsutani, Shimon Sakaguchi, Hiroshi Hata, Tomoyuki Tagami, Syuichi Nakatsuru, Izumi Negishi
Publikováno v:
Nature. 426:454-460
Rheumatoid arthritis (RA), which afflicts about 1% of the world population, is a chronic systemic inflammatory disease of unknown aetiology that primarily affects the synovial membranes of multiple joints. Although CD4(+) T cells seem to be the prime