Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Toshiko Koue"'
Autor:
PD Task Force, S. Mita, Tomohisa Saito, Saori Yaguchi, Masaru Hirano, Hisao Ochiai, Katsutoshi Hara, Toshiaki Tanaka, Junichi Yamamoto, Masanori Yamada, Mitsuo Higashimori, Toshiko Koue
Publikováno v:
Clinical pharmacology in drug development. 10(12)
Autor:
Kazumasa Fujitani, Fumio Nagashima, Kensei Yamaguchi, Taroh Satoh, Mika Tsujimoto, Yasushi Omuro, Tomohiro Nishina, Kaijiro Maeda, Toshiko Koue, Nozomu Machida
Publikováno v:
Gastric Cancer. 21:1041-1049
Ramucirumab, a monoclonal antibody vascular endothelial growth factor receptor-2 antagonist, given as monotherapy improved survival in a global phase 3 study (REGARD) of patients with gastric cancer. However, REGARD did not include Japanese patients.
Autor:
David Ferry, Sotaro Enatsu, Toshiko Koue, Kazuhiko Nakagawa, Nobuyuki Yamamoto, Kiyotaka Yoh, Takashi Nakamura, Yuichiro Ohe, Pablo Lee, Makoto Nishio, Kazuo Kasahara, Yukio Hosomi, Toshiaki Takahashi, Tomohide Tamura, Kazuhiko Yamada
Publikováno v:
Lung Cancer. 99:186-193
Objectives Ramucirumab plus docetaxel prolongs survival in patients with non-small cell lung cancer (NSCLC) with disease progression after platinum-based therapy. This phase II, double-blind, randomized, placebo-controlled study assessed efficacy and
Autor:
Koushi Higashi, Sachiko Kitahara, Sumiko Hara, Tamiki Katano, Junichi Azuma, Tomoko Hasunuma, Tsutomu Fujiwara, Masanori Kubo, Toshiko Koue, Masaya Miyatake
Publikováno v:
European Journal of Clinical Pharmacology
Purpose To investigate the effects of coadministration of paroxetine or fluvoxamine on the pharmacokinetics of aripiprazole in healthy adult Japanese with different CYP2D6 genotypes. Methods Fourteen CYP2D6 extensive metabolizer (EM) and 14 CYP2D6 in
Publikováno v:
Drug Metabolism and Pharmacokinetics. 22:358-366
We investigated the pharmacokinetics (PK) of aripiprazole, a newly developed antipsychotic, and its active metabolite in healthy Japanese, and the influence of CYP2D6 polymorphism on the PK of aripiprazole. Following a single oral 6 mg dose, the mean
Autor:
Atsuhiro Inaba, Hiroshi Takeda, Junichi Azuma, Hiromi Maune, Toshiko Koue, Tsuyoshi Fukuda, Masanori Kubo
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:55-64
The results of in vitro studies indicated that ARIPIPRAZOLE, a newly developed antipsychotic, is mainly metabolized by the human cytochrome P450 isozymes CYP3A4 and CYP2D6. The objective of the present study was to investigate the influence of itraco
Autor:
Yuko Otsuki, Toshiko Koue, Masato Yasuhara, Yukiya Hashimoto, Atsuko Odani, Mikihisa Takano, Kenichi Inui, Haruo Hattori, Kazunobu Takayanagi, Kenshi Furusho
Publikováno v:
Biological and Pharmaceutical Bulletin. 19:444-448
The population pharmacokinetic parameters of phenytoin were estimated using routine therapeutic drug monitoring data from 116 epileptic patients. The 531 serum concentration values at steady-state after repetitive oral administration were analyzed us
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 23:205-216
A simulation study was conducted to compare the cost and performance of various models for population analysis of the steady state pharmacokinetic data arising from a one-compartment model with Michaelis-Menten elimination. The usual Michaelis-Menten
Publikováno v:
Pharmaceutical Research. 11:545-548
A simulation study was conducted to compare the performance of alternative approaches for analyzing the distorted pharmacodynamic data. The pharmacodynamic data were assumed to be obtained from the natriurertic peptide-type drug, where the diuretic e
Publikováno v:
Drug metabolism and pharmacokinetics. 25(4)
A method for predicting the interindividual variability of human exposure for CYP3A4 substrates using Monte Carlo simulation was developed based on relevant factors. The coefficient of variation (CV) values for CYP3A4 content in human liver microsome