Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Toshiki Tabata"'
Autor:
Yasuyuki Kaneta, Takahiko Seki, Osamu Ubukata, Yumi Matsui, Shuhei Kishikawa, Takashi Shimada, Toshiki Tabata, Sho Takechi, Kosuke Takeuchi, Takeshi Shida, Yoshihiro Shibata, Ryo Murakami, Mana Hatanaka, Yoichi Munehira, Kohei Takano
Supplementary Tables from Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63db35c90bd3fa1e8ea96916e9e0705f
https://doi.org/10.1158/1535-7163.22523761.v1
https://doi.org/10.1158/1535-7163.22523761.v1
Autor:
Yasuyuki Kaneta, Takahiko Seki, Osamu Ubukata, Yumi Matsui, Shuhei Kishikawa, Takashi Shimada, Toshiki Tabata, Sho Takechi, Kosuke Takeuchi, Takeshi Shida, Yoshihiro Shibata, Ryo Murakami, Mana Hatanaka, Yoichi Munehira, Kohei Takano
Supplementary Figures from Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22757ff9c78ad64b565af1b3c30e1dd4
https://doi.org/10.1158/1535-7163.22523767
https://doi.org/10.1158/1535-7163.22523767
Autor:
Yasuyuki Kaneta, Takahiko Seki, Osamu Ubukata, Yumi Matsui, Shuhei Kishikawa, Takashi Shimada, Toshiki Tabata, Sho Takechi, Kosuke Takeuchi, Takeshi Shida, Yoshihiro Shibata, Ryo Murakami, Mana Hatanaka, Yoichi Munehira, Kohei Takano
Supplementary Methods from Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2c64c2d11235ff09916379c8ca2dd8
https://doi.org/10.1158/1535-7163.22523764.v1
https://doi.org/10.1158/1535-7163.22523764.v1
Autor:
Kohei Takano, Yoichi Munehira, Mana Hatanaka, Ryo Murakami, Yoshihiro Shibata, Takeshi Shida, Kosuke Takeuchi, Sho Takechi, Toshiki Tabata, Takashi Shimada, Shuhei Kishikawa, Yumi Matsui, Osamu Ubukata, Takahiko Seki, Yasuyuki Kaneta
Publikováno v:
Molecular cancer therapeutics.
Patients with melanoma with activating BRAF mutations (BRAF V600E/K) initially respond to combination therapy of BRAF and MEK inhibitors. However, their clinical efficacy is limited by acquired resistance, in some cases driven by amplification of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6040d68a8b817ab0dfc5fb7e8344a54
https://pubmed.ncbi.nlm.nih.gov/36622773
https://pubmed.ncbi.nlm.nih.gov/36622773
Autor:
M. Watanabe, Kazuhide Iwasaki, Shinsaku Naito, Sato Yasushi, Tsuyoshi Yokoi, Toshiki Tabata, Miki Katoh, M. Nishimura, Chise Tateno, Miki Nakajima, Katsutoshi Yoshizato
Publikováno v:
Xenobiotica. 35:863-875
The induction of human cytochrome P450 enzymes (CYPs) often poses a serious problem in clinical practice. The induction of CYP3A leads to a decrease in the pharmacological potency of drugs, since many drugs are substrates of CYP3A. The present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94de2a39166535665d99ff951afed66
https://doi.org/10.1080/00498250500296231
https://doi.org/10.1080/00498250500296231
Autor:
Miki Nakajima, Tsuyoshi Yokoi, Kan Chiba, Toshiki Tabata, Masakiyo Hosakawa, Miki Katoh, Shogo Tokudome
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(7)
Capecitabine, an anticancer prodrug, is thought to be biotransformed into active 5-fluorouracil (5-FU) by three enzymes. After oral administration, capecitabine is first metabolized to 5'-deoxy-5-fluorocytidine (5'-DFCR) by carboxylesterase (CES), th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3676bfde80aa5c760ca6741293b4bf2
https://pubmed.ncbi.nlm.nih.gov/15205393
https://pubmed.ncbi.nlm.nih.gov/15205393
Autor:
Toshiki, Tabata, Miki, Katoh, Shogo, Tokudome, Masakiyo, Hosakawa, Kan, Chiba, Miki, Nakajima, Tsuyoshi, Yokoi
Publikováno v:
Drug Metabolism and Disposition; July 2004, Vol. 32 Issue: 7 p762-7, 6p