Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Toshiki, Mizuno"'
Autor:
Tetsuhiro Ueda, Toshihide Takeuchi, Nobuhiro Fujikake, Mari Suzuki, Eiko N. Minakawa, Morio Ueyama, Yuzo Fujino, Nobuyuki Kimura, Seiichi Nagano, Akio Yokoseki, Osamu Onodera, Hideki Mochizuki, Toshiki Mizuno, Keiji Wada, Yoshitaka Nagai
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TDP-43 is aberrantly accumulated in the ne
Externí odkaz:
https://doaj.org/article/01c84c3ce0384f509847436ec4ff47eb
Autor:
Noritaka Wakasugi, Harumasa Takano, Mitsunari Abe, Nobukatsu Sawamoto, Toshiya Murai, Toshiki Mizuno, Teruyuki Matsuoka, Ryo Yamakuni, Hirooki Yabe, Hiroshi Matsuda, Takashi Hanakawa, Parkinson’s and Alzheimer’s disease Dimensional Neuroimaging Initiative (PADNI)
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundDopamine transporter single-photon emission computed tomography (DAT-SPECT) is a crucial tool for evaluating patients with Parkinson’s disease (PD). However, its implication is limited by inter-site variability in large multisite clinical
Externí odkaz:
https://doaj.org/article/9750fd33b2e04876bf209159987c138a
Autor:
Satoshi Saito, Soichiro Abe, Kunihiro Nishimura, Toshiki Mizuno, Osamu Onodera, Sung-Chun Tang, Yi-Chung Lee, Jay Chol Choi, Masafumi Ihara
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100336- (2024)
Introduction: Recent advancements in genomic research have revealed that 9 individuals per 1,000 population in East Asia and 3.4 individuals per 1,000 population worldwide carry cysteine-altering NOTCH3 variants in the epidermal growth factor-like re
Externí odkaz:
https://doaj.org/article/8ecdc396b8eb4fec89344800d91fa4ed
Autor:
Toshiki Mizuno, Tomoyuki Ohara, Ikuko Mizuta, Akiko Watanabe-Hosomi, Hiraku Matsuura, Daiki Fukunaga, Akari Naito, Mitsuko Nakata, Aoi Uno, Yayoi Iwami, Toshiko Ito-Ihara, Satoshi Teramukai
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100350- (2024)
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by mutations in NOTCH3. CADASIL patients experienced recurrent strokes in middle age, resulting
Externí odkaz:
https://doaj.org/article/d19d915b59434b3f8b516e1de236fb5c
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100227- (2024)
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a monogenic disorder caused by mutations in the NOTCH3 gene. The main aim of our survey was to determine if there is an association between phenot
Externí odkaz:
https://doaj.org/article/904a666eb9ab4f27a1aebf256b3325ee
Autor:
Jun Fujinami, Yoshinari Nagakane, Kei Fujikawa, Shohei Murata, Keiko Maezono, Tomoyuki Ohara, Toshiki Mizuno
Publikováno v:
Cerebrovascular Diseases Extra (2023)
Abstract Introduction: In patients with cancer-associated hypercoagulability (CAH)-related stroke, D-dimer trends after anticoagulant therapy may offer a biomarker of treatment efficacy. The purpose of this study was to clarify the association betwee
Externí odkaz:
https://doaj.org/article/e6d19ce28c064362a88fcee49a134635
Autor:
Toshiki Mizuno PT, MSc, Kayo Godai RN, PhD, Mai Kabayama PHN, PhD, Hiroshi Akasaka MD, PhD, Michiko Kido RN, MSN, Masaaki Isaka PT, PhD, Mio Kubo PHN, MSc, Yasuyuki Gondo PhD, Madoka Ogawa PhD, Kazunori Ikebe DDS, PhD, Yukie Masui PhD, Yasumichi Arai MD, PhD, Tatsuro Ishizaki MD, PhD, Hiromi Rakugi MD, PhD, Kei Kamide MD, PhD
Publikováno v:
Gerontology and Geriatric Medicine, Vol 9 (2023)
Objective: We aimed to determine whether the association of sleep status with frailty differs between age groups of older adults. Method: This cross-sectional study was part of the observational Septuagenarians, Octogenarians, Nonagenarians Investiga
Externí odkaz:
https://doaj.org/article/e765570fcc3b49f69842508c3395661c
Autor:
Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori, Eiichi Tokuda, Tomoya Taminato, Takuya Konno, Akihide Koyama, Yuya Kawabe, Toshihide Takeuchi, Yoshiaki Furukawa, Toshimichi Fujiwara, Manabu Ikeda, Toshiki Mizuno, Hideki Mochizuki, Hidehiro Mizusawa, Keiji Wada, Kinya Ishikawa, Osamu Onodera, Kazuhiko Nakatani, Leonard Petrucelli, Hideki Taguchi, Yoshitaka Nagai
Publikováno v:
eLife, Vol 12 (2023)
Abnormal expansions of GGGGCC repeat sequence in the noncoding region of the C9orf72 gene is the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (C9-ALS/FTD). The expanded repeat sequence is translated into dip
Externí odkaz:
https://doaj.org/article/8c6f0fd5d0eb4801aca51cdb76aeb73a
Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 127 (2024)
Notch signaling is conserved in C. elegans, Drosophila, and mammals. Among the four NOTCH genes in humans, NOTCH1, NOTCH2, and NOTCH3 are known to cause monogenic hereditary disorders. Most NOTCH-related disorders are congenital and caused by a gain
Externí odkaz:
https://doaj.org/article/61373c558c2c48a4ad9bdc0e5279f166
Autor:
Satoshi Saito, Satoshi Hosoki, Eriko Yamaguchi, Hiroyuki Ishiyama, Soichiro Abe, Takeshi Yoshimoto, Tomotaka Tanaka, Yi Chu Liao, Yi-Chung Lee, Ikuko Mizuta, Toshiki Mizuno, Masafumi Ihara
Publikováno v:
Neurology: Genetics; Oct2024, Vol. 10 Issue 5, p1-4, 4p