Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Toshikazu Hakogi"'
Autor:
Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi, Hirokazu Sugiyama
Publikováno v:
Reaction Chemistry & Engineering.
Extensive kinetic investigations were performed to identify novel reaction pathways and assess their feasibility to resolve contradictions in the reported understanding of an amination reaction via nucleophilic aromatic substitution.
Autor:
Shoji Shinomoto, Yutaka Nishino, Naoki Miyake, Yuki Fukui, Masahiko Nagai, Tatsuro Yasukata, Takao Ooyama, Toshikazu Hakogi, Yasunori Aoyama, Yoshiyuki Taoda, Daisuke Yamada, Hiroshi Yoshida
Publikováno v:
Organic Process Research & Development. 23:558-564
A practical and scalable synthetic method to obtain dolutegravir sodium (1) was established starting from the readily accessible material maltol (2). This synthetic method includes a scalable oxidation process of maltol and palladium-catalyzed amidat
Autor:
Yasunori Aoyama, Yuki Fukui, Yohei Takagi, Masayoshi Ogawa, Hiroyuki Suzuki, Hideyuki Kitamura, Junko Kikuchi, Toshikazu Hakogi, Daisuke Yamada, Shinichi Oda
Publikováno v:
Organic Process Research & Development. 16:1783-1786
A high-yield robust LHMDS-mediated aldol-type reaction of benzyl maltol (2) and benzaldehyde (3) was developed using in situ IR to overcome the problems of low yield and yield fluctuation of the pilot synthesis. In situ IR studies indicated that unex
Publikováno v:
Organic Process Research & Development. 16:220-224
A practical synthesis of O-(2-(pyrazol-1-yl)pyridin-5-yl)methylhydroxylamine was achieved from the inexpensive raw materials, 2-chloro-5-chloromethylpyridine, pyrazole, and acetone oxime, using com...
Publikováno v:
Organic Letters. 8:3809-3812
[reaction: see text] A one-pot procedure for tetracyclic chiral aminoacetals, the useful precursors for substituted piperidine synthesis, has been established via Stille-Migita coupling, 6pi-azaelectrocyclization, and aminoacetal formation from readi
Publikováno v:
Tetrahedron Letters. 47:2627-2630
As a new sphingomyelinase inhibitor, a novel sphingomyelin CF2 analogue was designed and synthesized. One key step of this synthesis is the very mild hydrolysis of the oxazolidinone ring, a suitable intermediate for the introduction of a diethyl difl
Publikováno v:
Organic Letters. 5:2801-2804
[structure: see text] Sphingomyelin nitrogen analogue 1 was designed and synthesized as a sphingomyelinase inhibitor. The synthesis was established by continuous Hofmann rearrangement and Crutius rearrangement as key steps in constructing the 3-hydro
Autor:
Toshikazu Hakogi, Yasuyuki Igarashi, Takamitsu Sano, Toshihiko Shigenari, Shigeo Katsumura, Takayuki Kohno
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:661-664
A fluorescence-labeled sphingosine and sphingosine 1-phosphate have been successfully synthesized from the oxazolidinone methyl ester derived from glycidol via monoalkylation and the stereoselective reduction of the resulting ketone. The labeled sphi
Publikováno v:
ChemInform. 30
Deoxyazasugars such as deoxymannojirimycin, deoxyaltrojirimycin and deoxygalactostatin were stereoselectively synthesized starting from (R)-(+)-4-methoxycarbonyloxazolidinone via a bicyclic oxazolidinylpiperidine as a common synthetic intermediate.
Publikováno v:
ChemInform. 39
The methylene and sulfur analogues of sphingosine 1 -phosphate labeled with a fluorescent group at the terminus of the backbone skeleton were stereoselectively synthesized as possible nonhydrolyzable visible ligands to the sphingosine 1-phosphate rec