Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Toshikazu Araoka"'
Autor:
Cheng Ma, Ramin Banan Sadeghian, Ryosuke Negoro, Kazuya Fujimoto, Toshikazu Araoka, Naoki Ishiguro, Minoru Takasato, Ryuji Yokokawa
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110760- (2024)
Summary: Renal transporters play critical roles in predicting potential drug-drug interactions. However, current in vitro models often fail to adequately express these transporters, particularly solute carrier proteins, including organic anion transp
Externí odkaz:
https://doaj.org/article/991f439ff2a947e5acef506476ba01c5
Autor:
Hiraku Tsujimoto, Azusa Hoshina, Shin-Ichi Mae, Toshikazu Araoka, Wang Changting, Yoshihiro Ijiri, May Nakajima-Koyama, Satoko Sakurai, Kazusa Okita, Ken Mizuta, Akira Niwa, Megumu K. Saito, Mitinori Saitou, Takuya Yamamoto, Cecilia Graneli, Kevin J. Woollard, Kenji Osafune
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113602- (2024)
Summary: Recent regenerative studies using human pluripotent stem cells (hPSCs) have developed multiple kidney-lineage cells and organoids. However, to further form functional segments of the kidney, interactions of epithelial and interstitial cells
Externí odkaz:
https://doaj.org/article/0ff925a8f95745d09e7a299bf70b6721
Autor:
Ryuichiro Hirayama, Kosuke Toyohara, Kei Watanabe, Takeya Otsuki, Toshikazu Araoka, Shin-Ichi Mae, Tomoko Horinouchi, Tomohiko Yamamura, Keisuke Okita, Akitsu Hotta, Kazumoto Iijima, Kandai Nozu, Kenji Osafune
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Alport syndrome (AS) is a hereditary glomerulonephritis caused by COL4A3, COL4A4 or COL4A5 gene mutations and characterized by abnormalities of glomerular basement membranes (GBMs). Due to a lack of curative treatments, the condition proceed
Externí odkaz:
https://doaj.org/article/d35615f2c8824439a7a88aa52196dc4a
Autor:
Ramin Banan Sadeghian, Ryohei Ueno, Yuji Takata, Akihiko Kawakami, Cheng Ma, Toshikazu Araoka, Minoru Takasato, Ryuji Yokokawa
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Of late, numerous microphysiological systems have been employed to model the renal proximal tubule. Yet there is lack of research on refining the functions of the proximal tubule epithelial layer—selective filtration and reabsorption. In t
Externí odkaz:
https://doaj.org/article/3ca6e124d72a4236b880fb504ef58367
Autor:
Hiraku Tsujimoto, Tomoko Kasahara, Shin-ichi Sueta, Toshikazu Araoka, Satoko Sakamoto, Chihiro Okada, Shin-ichi Mae, Taiki Nakajima, Natsumi Okamoto, Daisuke Taura, Makoto Nasu, Tatsuya Shimizu, Makoto Ryosaka, Zhongwei Li, Masakatsu Sone, Makoto Ikeya, Akira Watanabe, Kenji Osafune
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Recent studies using human pluripotent stem cells (hPSCs) have developed protocols to induce kidney-lineage cells and reconstruct kidney organoids. However, the separate generation of metanephric nephron progenitors (NPs), mesonephric NPs, a
Externí odkaz:
https://doaj.org/article/1971024dbc1f452eb33770678d7f5ce1
Autor:
Toshikazu Araoka, Shin-ichi Mae, Yuko Kurose, Motonari Uesugi, Akira Ohta, Shinya Yamanaka, Kenji Osafune
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84881 (2014)
The first step in developing regenerative medicine approaches to treat renal diseases using pluripotent stem cells must be the generation of intermediate mesoderm (IM), an embryonic germ layer that gives rise to kidneys. In order to achieve this goal
Externí odkaz:
https://doaj.org/article/cb7b979c60d9415a913f4a42cace4cc9
Autor:
Kojiro Nagai, Masashi Miyoshi, Takei Kake, Naoshi Fukushima, Motokazu Matsuura, Eriko Shibata, Satoshi Yamada, Kazuhiro Yoshikawa, Hiro-Omi Kanayama, Tomoya Fukawa, Kunihisa Yamaguchi, Hirofumi Izaki, Akira Mima, Naoko Abe, Toshikazu Araoka, Taichi Murakami, Fumi Kishi, Seiji Kishi, Tatsuya Tominaga, Tatsumi Moriya, Hideharu Abe, Toshio Doi
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66759 (2013)
BACKGROUND: Gas6 is a growth factor that causes proliferation of mesangial cells in the development of glomerulonephritis. Gas6 can bind to three kinds of receptors; Axl, Dtk, and Mer. However, their expression and functions are not entirely clear in
Externí odkaz:
https://doaj.org/article/63bc84eb2b144edf8df345f66a6674c2
Autor:
Kazuyoshi Yamamoto, Masahiro Okabe, Keiko Tanaka, Takashi Yokoo, Ira Pastan, Toshikazu Araoka, Kenji Osafune, Tomohiro Udagawa, Masahiro Koizumi, Taiji Matsusaka
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F515-F526
Although apoptosis of podocytes has been widely reported in in vitro studies, it has been less frequently and less definitively documented in in vivo situations. To investigate this discrepancy, we analyzed the dying process of podocytes in vitro and
Autor:
Kenji Osafune, Tatsutoshi Nakahata, Toshikazu Araoka, Akira Ohta, Hiraku Tsujimoto, Yohei Nishi
Publikováno v:
Biochemical and Biophysical Research Communications. 558:231-238
Several groups have developed in vitro expansion cultures for mouse metanephric nephron progenitor cells (NPCs) using cocktails of small molecules and growth factors including BMP7. However, the detailed mechanisms by which BMP7 acts in the NPC expan
Autor:
Shin-Ichi Mae, Tatsuya Shimizu, Keisuke Okita, Toshikazu Araoka, Kenji Osafune, Akitsu Hotta, Kunihiro Yamagata
Publikováno v:
Biochemical and Biophysical Research Communications. 529:1186-1194
Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder which manifests progressive renal cyst formation and leads to end-stage kidney disease. Around 85% of cases are caused by PKD1 heterozygous mutations, exhibiting relatively