Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Toshiji, Saibara"'
Autor:
Kotaro Kanno, Masahiro Koseki, Jiuyang Chang, Ayami Saga, Hiroyasu Inui, Takeshi Okada, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Seiko Ide, Shigeyoshi Saito, Tomoaki Higo, Daisuke Okuzaki, Tohru Ohama, Makoto Nishida, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Shizuya Yamashita, Yasushi Sakata
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Although patients with nonalcoholic fatty liver disease have been reported to have cardiac dysfunction, and appropriate model has not been reported. We established a novel mouse model of diet-induced steatohepatitis-related cardiomyopathy an
Externí odkaz:
https://doaj.org/article/f417ef3745a84a19b9a8a2bc5596ce26
Autor:
Tatsuya Kitagawa, Keisuke Taniuchi, Makiko Tsuboi, Masahiko Sakaguchi, Takuhiro Kohsaki, Takehiro Okabayashi, Toshiji Saibara
Publikováno v:
Molecular Oncology, Vol 13, Iss 2, Pp 212-227 (2019)
Diagnostic biomarkers for the early diagnosis of pancreatic cancer are needed to improve prognosis for this disease. The aim of this study was to investigate differences in the expression of four messenger RNAs (mRNAs: CCDC88A, ARF6, Vav3, and WASF2)
Externí odkaz:
https://doaj.org/article/3dc8f8cc789b488caf999488515a2ee5
Autor:
Jiuyang Chang, Masahiro Koseki, Ayami Saga, Kotaro Kanno, Tomoaki Higo, Daisuke Okuzaki, Takeshi Okada, Hiroyasu Inui, Katsunao Tanaka, Masumi Asaji, Yinghong Zhu, Yoshihiro Kamada, Masafumi Ono, Toshiji Saibara, Ikuyo Ichi, Tohru Ohama, Makoto Nishida, Shizuya Yamashita, Yasushi Sakata
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Non-alcoholic fatty liver disease is strongly associated with obese and type 2 diabetes. It has been reported that an oxidized cholesterol, 7-ketocholesterol (7KC), might cause inflammatory response in macrophages and plasma 7KC concentration were hi
Externí odkaz:
https://doaj.org/article/9d4183de3c844781921e3dc272be5b86
Publikováno v:
Cancer Medicine, Vol 7, Iss 11, Pp 5733-5751 (2018)
Abstract WAVE2 is a member of the WASP/WAVE family of actin cytoskeletal regulatory proteins; unfortunately, little is known about its function in pancreatic cancers. In this study, we report the role of WAVE2 in the motility and invasiveness of panc
Externí odkaz:
https://doaj.org/article/af80c4bba28345dfbbd3e58da09a1c73
Autor:
Yoshihiro Kamada, Masafumi Ono, Hideyuki Hyogo, Hideki Fujii, Yoshio Sumida, Makoto Yamada, Kojiroh Mori, Saiyu Tanaka, Tomohiro Maekawa, Yusuke Ebisutani, Akiko Yamamoto, Shinji Takamatsu, Masashi Yoneda, Norifumi Kawada, Kazuaki Chayama, Toshiji Saibara, Tetsuo Takehara, Eiji Miyoshi, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG‐NAFLD)
Publikováno v:
Hepatology Communications, Vol 1, Iss 8, Pp 780-791 (2017)
In contrast to patients with viral hepatitis, patients with nonalcoholic fatty liver disease (NAFLD) can progress to hepatocellular carcinoma during the initial stages of liver fibrosis. Development and implementation of noninvasive methods for diagn
Externí odkaz:
https://doaj.org/article/77fb315750e24030ad6716b0f0aaaf24
Autor:
Satoko Ohmi, Masafumi Ono, Hiroshi Takata, Seiki Hirano, Shogo Funakoshi, Yuichi Nishi, Kumiko Yoshimura, Eri Amano, Yoshio Terada, Toshiji Saibara, Shimpei Fujimoto
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 9, Iss 1, Pp 1-9 (2017)
Abstract Background While the association of the prevalence of non-alcoholic fatty liver disease (NAFLD) with impaired glucose metabolism has been reported, the factors influencing glucose tolerance in NAFLD remain to be clarified. Methods Glucose to
Externí odkaz:
https://doaj.org/article/1b7a580f2dcd43ecae7e8ed2f78b65d2
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217920 (2019)
We previously reported that overexpression of PODXL, BCL7B, and ARHGEF4 in pancreatic cancer tissue is correlated with pancreatic cancer-related survival. The aim of this study was to investigate the use of PODXL, BCL7B, ARHGEF4, and the integrin fam
Externí odkaz:
https://doaj.org/article/afa1b55735db41c79c3752a8ed710d1c
Publikováno v:
Heliyon, Vol 4, Iss 9, Pp e00772- (2018)
The importance of estrogens for glucose homeostasis has been demonstrated by clinical, pharmacological, and experimental studies. Male mice lacking the aromatase gene (ArKO mice), which encodes an enzyme involved in estrogen synthesis, develop glucos
Externí odkaz:
https://doaj.org/article/be675c92c7fd44ac938a6acb49865879
Autor:
Yosuke Osawa, Keisuke Oboki, Jun Imamura, Ekumi Kojika, Yukiko Hayashi, Tsunekazu Hishima, Toshiji Saibara, Futoshi Shibasaki, Michinori Kohara, Kiminori Kimura
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1751-1758 (2015)
Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To exp
Externí odkaz:
https://doaj.org/article/81a09b6ff5ec4ed48bca6a53ae006d9a
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 12, Pp 1082-1093 (2014)
Pancreatic cancers are aggressive because they are highly invasive and highly metastatic; moreover, effective treatments for aggressive pancreatic cancers are lacking. Here, we report that the motor kinesin protein KIF20A promoted the motility and in
Externí odkaz:
https://doaj.org/article/00d9dd4082fd448592ff02044eee5a80