Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Toshihito Tsutsumi"'
Autor:
Eiichi Katsumoto, Toru Ishida, Kenji Kinoshita, Miho Shimizu, Toshihito Tsutsumi, Yoko Nagai, Masakazu Nishimura, Toshio Yokouchi, Yasushi Yoshida
Publikováno v:
Frontiers in Nutrition, Vol 7 (2021)
Yokukansankachimpihange is a Japanese herbal medicine reported to benefit anxiety and sleep disorders, and it has recently been introduced to treat behavioral and psychological symptoms of dementia. There are no multicenter studies of its effectivene
Externí odkaz:
https://doaj.org/article/25eabaf75a7f448fb76a00f180a137e4
Autor:
Toshihito Tsutsumi, Taishi Higashi, Fumitoshi Hirayama, Hidetoshi Arima, Kaneto Uekama, Keiichi Motoyama, Haruna Ikeda, Ayumi Yoshimatsu
Publikováno v:
European Journal of Pharmaceutical Sciences. 44:375-384
In the present study, we prepared the small interfering RNA (siRNA) complexes with polyamidoamine (PAMAM) dendrimer (G3) conjugate with α-cyclodextrin (α-CDE (G3)), and examined the physicochemical properties, serum resistance, in vitro RNAi effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cc9a393fb93c1e52a6650b953f9659
https://doi.org/10.1016/j.ejps.2011.08.019
https://doi.org/10.1016/j.ejps.2011.08.019
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 56:81-84
RNA interference (RNAi) is the mechanism of gene silencing-mediated messenger RNA degradation by small interference RNA (siRNA), which becomes a powerful tool for genetic analysis and novel gene therapy. However, one of the major obstacles for siRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d60a7c82b46f0216a95218e8a9592542
https://doi.org/10.1007/s10847-006-9065-6
https://doi.org/10.1007/s10847-006-9065-6
Autor:
Hidetoshi Arima, Fumitoshi Hirayama, Kaneto Uekama, Koki Wada, Kenjiro Hattori, Yuko Chihara, Toshihito Tsutsumi
Publikováno v:
Journal of Controlled Release. 104:397-413
The purpose of this study is to evaluate in vitro and in vivo gene delivery efficiency of polyamidoamine (PAMAM) starburst dendrimer (generation 2, G2) conjugate with alpha-cyclodextrin (alpha-CDE conjugate (G2)) bearing mannose (Man-alpha-CDE conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f2a5ffe1f9d3e1e90f42dc455573d6
https://doi.org/10.1016/j.jconrel.2005.02.016
https://doi.org/10.1016/j.jconrel.2005.02.016
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:500-505
To improve in vitro gene transfer efficiency and/or achieve cell-specific gene delivery of polyamidoamine (PAMAM) starburst dendrimer (generation 2, G2) conjugate with alpha-cyclodextrin (alpha-CDE conjugate (G2)), we prepared alpha-CDE conjugate bea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d953b03d0a9bb29074f8d9a6c06b8a
https://doi.org/10.1248/bpb.28.500
https://doi.org/10.1248/bpb.28.500
Publikováno v:
Bioconjugate Chemistry. 14:342-350
The purpose of the present study is to optimize the structure of the polyamidoamine starburst dendrimer (dendrimer) conjugate with alpha-cyclodextrin (alpha-CDE conjugate) as a nonviral vector. alpha-CDE conjugates of dendrimer (generation 3, G3) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1a9c7cab22d100f6817bcb386375e7
https://doi.org/10.1021/bc025613a
https://doi.org/10.1021/bc025613a
Autor:
Kaneto Uekama, Hidetoshi Arima, Fumihiro Kihara, Koki Wada, Fumitoshi Hirayama, Toshihito Tsutsumi
Publikováno v:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. 44:361-364
To improve the activity and the cell specificity of gene transferof polyamidoamine starburst dendrimer, we prepared α-CyD conjugates with mannosylateddendrimers (generation 2 (G2), man-α-CDE conjugates) having various degrees of substitution(DS) of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6254a1b1e80194277c3c45d054b7433
https://doi.org/10.1023/a:1023092508646
https://doi.org/10.1023/a:1023092508646
Publikováno v:
Journal of pharmaceutical sciences. 97(8)
The potential of starburst® polyamidoamine dendrimer (dendrimer, generation 3, G3) conjugate with α-cyclodextrin (α-CyD) having an average degree of substitution of 2.4 (α-CDE) as a novel carrier of short hairpin RNA (shRNA) expressing plasmid DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc32367fe62d2ca306d1f93c07cf450
https://pubmed.ncbi.nlm.nih.gov/17932986
https://pubmed.ncbi.nlm.nih.gov/17932986
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 119(3)
As the first step toward an evaluation of the potential use of the PAMAM dendrimer (G3) conjugate with alpha-cyclodextrin (alpha-CDE) for a small interfering RNA (siRNA) carrier, the ternary complexes of alpha-CDE or the transfection reagents such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3291f253fdcb9e5ce75a689cad0372e5
https://pubmed.ncbi.nlm.nih.gov/17477999
https://pubmed.ncbi.nlm.nih.gov/17477999
Publikováno v:
Bioconjugate chemistry. 13(6)
To improve gene transfer activity of a new nonviral vector, a polyamidoamine dendrimer (G2) conjugate with alpha-cyclodextrin (alpha-CDE conjugate (G2)), we prepared alpha-CDE conjugates with dendrimer having different generations (G3 and G4), and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3685ee99ed7f743de1e7786b77eb9cfb
https://pubmed.ncbi.nlm.nih.gov/12440855
https://pubmed.ncbi.nlm.nih.gov/12440855