Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Toshihisa Sumii"'
Publikováno v:
Journal of Neurosurgery: Spine. 6:165-168
✓The authors present a rare case of cervical myelopathy caused by dropped head syndrome. This 68-year-old woman presented with her head hanging forward. After 1 month, she was admitted to the medical service because of head drop progression. Examin
Autor:
Sunu S. Thomas, James K. Liao, Zhihong Huang, Jianhua Qiu, Toshihisa Sumii, Sepideh Amin-Hanjani, Eng H. Lo, Minoru Asahi, Michael A. Moskowitz, Tatsuro Mori, Shinichi Yoshimura, Paul L. Huang
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 25:722-729
Previous studies have shown that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) protect brain against ischemic injury by upregulating endothelial nitric oxide synthase (eNOS). Here, we tested the hypothesis that statin
Autor:
Vladimir P. Torchilin, Robert Jan Pauw, Toshihisa Sumii, Eng H. Lo, Minoru Asahi, Volkmar Weissig, Ram Rammohan, Xiaoying Wang
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 23:895-899
Thrombolytic stroke therapy with tissue plasminogen activator (tPA) is limited by serious risks of intracerebral hemorrhage. In this study, the authors show that a novel antiactin-targeted immunoliposome significantly reduced tPA-induced hemorrhage i
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 22:861-868
Recent studies suggest that normobaric hyperoxia can be beneficial, if administered during transient stroke. However, increased oxygenation theoretically may increase oxygen free-radical injury, particularly during reperfusion. In the present study,
Publikováno v:
Stroke. 33:1882-1888
Background and Purpose — Apoptotic-like pathways may contribute to brain cell death after intracerebral hemorrhage. In this study, we used a simplified in vitro model of hemoglobin neurotoxicity to map the caspase cascades involved and to document
Autor:
Eng H. Lo, Bruce R. Rosen, Minoru Asahi, Ona Wu, Masao Sasamata, Leif Østergaard, Rick M. Dijkhuizen, Toshihisa Sumii
Publikováno v:
Wu, O, Sumii, T, Asahi, M, Sasamata, M, Østergaard, L, Rosen, BR, Lo, EH & Dijkhuizen, RM 2007, ' Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models ', Journal of Cerebral Blood Flow and Metabolism, vol. 27, no. 1, pp. 196-204 . https://doi.org/10.1038/sj.jcbfm.9600328
There is increasing interest in using algorithms combining multiple magnetic resonance imaging (MRI) modalities to predict tissue infarction in acute human stroke. We developed and tested a voxel-based generalized linear model (GLM) algorithm to pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29687021edfe1010bafcef0e5061da9
https://pure.au.dk/portal/da/publications/infarct-prediction-and-treatment-assessment-with-mribased-algorithms-in-experimental-stroke-models(66870680-c714-11db-bee9-02004c4f4f50).html
https://pure.au.dk/portal/da/publications/infarct-prediction-and-treatment-assessment-with-mribased-algorithms-in-experimental-stroke-models(66870680-c714-11db-bee9-02004c4f4f50).html
Publikováno v:
Stroke. 33(11)
Background and Purpose— Most experimental models of cerebral ischemia use mechanical methods of occlusion and reperfusion. However, differences between mechanical reperfusion versus clot thrombolysis may influence reperfusion injury profiles. In th
Autor:
C. Edward Dixon, Eng H. Lo, Alessandro Alessandrini, Toshihisa Sumii, Aneesh B. Singhal, M. Elizabeth Fini, Xiaoying Wang, Tatsuro Mori, Jae-Chang Jung
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 22(4)
The authors provide the first in vitro and in vivo evidence that perturbations in mitogen-activated protein kinase (MAPK) signal-transduction pathways are involved in the pathophysiology of traumatic brain injury. In primary rat cortical cultures, me
Autor:
Toshihisa Sumii, Eng H. Lo
Publikováno v:
Stroke. 33(3)
Background and Purpose — Thrombolytic therapy with tissue plasminogen activator (tPA) for acute ischemic stroke remains complicated by risks of hemorrhagic transformation. In this study we used a previously established quantitative rat model of tPA
Publikováno v:
Neuroreport. 12(13)
Matrix metalloproteinases (MMPs) may contribute to tissue damage after cerebral ischemia. In this study, wildtype and MMP-2 knockout mice were subjected to permanent and transient (2 h) occlusions of the middle cerebral artery. Gelatin zymography sho