Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Toshihisa Koga"'
Autor:
Toshihisa Koga1 Koga.Toshihisa@otsuka.jp, Yuko Sahara1, Tadaaki Ohtani1, Kaneko Yosuke1, Ken Umehara1
Publikováno v:
Journal of Toxicological Sciences. 2024, Vol. 49 Issue 3, p95-103. 9p.
Publikováno v:
Journal of Toxicological Sciences. 2023, Vol. 48 Issue 1, p47-56. 10p.
Autor:
Hiroyuki Sasabe, Yosuke Kaneko, Masayuki Furukawa, Masayuki Matsunaga, Eiji Kashiyama, Yukihiro Hirao, Mitsuhiko Kawabata, Noriyuki Koyama, Toshihisa Koga, Hitomi Akazawa, Kenji Takeuchi
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 51(5)
The pharmacokinetics of brexpiprazole were investigated in the in vitro and in vivo.The total body clearance of brexpiprazole in rat and monkey was 2.32 and 0.326 L/h/kg, respectively, after intrav...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7762bcff7a84c2ea001970b465d606
https://pubmed.ncbi.nlm.nih.gov/33685346
https://pubmed.ncbi.nlm.nih.gov/33685346
Autor:
Yoshihiro Oozone, Kenji Takeuchi, Toshihisa Koga, Mikako Torii, Hiroyuki Sasabe, Kenta Hashizume, Masayuki Furukawa, Eiji Kashiyama, Katsunori Sasahara, Masayuki Matsunaga, Immaculate Amunom, Ken Umehara
Brexpiprazole, a serotonin-dopamine activity modulator, is indicated for the treatment of schizophrenia and also adjunctive therapy to antidepressants for the treatment of Major Depressive Disorder. To determine the drug–drug interaction risk for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29151a5c5a878c6d2180e051391267d
Autor:
Satoshi Kondo, Hajime Toguchi, Noriaki Yoda, Chie Emoto, Toshihisa Koga, Tadashi Mukai, Masateru Miyake
Publikováno v:
European Journal of Pharmaceutical Sciences. 96:373-380
An adequate evaluation system for drug intestinal absorption is essential in the pharmaceutical industry. Previously, we established a novel prediction system of drug intestinal absorption in humans, using the mini-Ussing chamber equipped with human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21abc729388fa28ed9513f02bfe30f57
https://doi.org/10.1016/j.ejps.2016.10.006
https://doi.org/10.1016/j.ejps.2016.10.006
Publikováno v:
American Journal of Analytical Chemistry. :98-105
Sensitive and selective liquid chromatography-tandem mass spectrometry methods have been developed and validated for the determination of delamanid in mouse plasma and lung. Sample preparation involved liquid-liquid extraction with diethyl ether for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b925d77a672241464fff38f3231fab63
https://doi.org/10.4236/ajac.2015.62009
https://doi.org/10.4236/ajac.2015.62009
Autor:
Hajime Toguchi, Masateru Miyake, Satoshi Kondo, Tadashi Mukai, Chie Emoto, Satoru Nakazato, Noriaki Yoda, Toshihisa Koga
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 122
The purpose of this study was to evaluate the intestinal metabolism and absorption in a mini-Ussing chamber equipped with animal intestinal tissues, based on the transport index (TI). TI value was defined as the sum of drug amounts transported to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5c7457fbf658d8a62b7fecf7322c62
https://pubmed.ncbi.nlm.nih.gov/28974435
https://pubmed.ncbi.nlm.nih.gov/28974435
Autor:
Miki Nakajima, Tsuyoshi Yokoi, Ryoichi Fujiwara, Hiroyuki Yamanaka, Haruko Sakai, Toshihisa Koga
Publikováno v:
Biochemical Pharmacology. 79(8):1165-1172
金沢大学医薬保健研究域薬学系
UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation of a variety of xeno/endobiotics. UGTs are type I membrane proteins of the endoplasmic reticulum (ER) with a glycosylated luminal domain.
UDP-glucuronosyltransferases (UGTs) catalyze the glucuronidation of a variety of xeno/endobiotics. UGTs are type I membrane proteins of the endoplasmic reticulum (ER) with a glycosylated luminal domain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933ee6cdd81ce682903828356e429bd4
http://hdl.handle.net/2297/23493
http://hdl.handle.net/2297/23493
Autor:
Takefumi Shimizu, Hitoshi Sato, Toshihisa Koga, Minoru Itose, Makoto Inada, Jun-Ichi Kunizaki, Yukihiro Hirao
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 25:1205-1209
A physiologically based pharmacokinetic (PBPK) model to simulate the plasma concentration and 13CO2 exhalation after [2-13C]uracil administration to DPD-suppressed dogs was developed. Simulation using this PBPK model should be useful in clinical situ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1312c90a1fd70bead84dfabf20f485
https://doi.org/10.1080/15257770600894550
https://doi.org/10.1080/15257770600894550
Autor:
Takefumi Shimizu, Yukihiro Hirao, Takeshi Kawamura, Yoshiharu Inoue, Toshihisa Koga, Suminobu Ito, Jun-Ichi Kunizaki, Makoto Inada, Hitoshi Sato
Publikováno v:
British Journal of Clinical Pharmacology. 60:584-593
Aims Approximately 80% of uracil is excreted as β-alanine, ammonia and CO2 via three sequential reactions. The activity of the first enzyme in this scheme, dihydropyrimidine dehydrogenase (DPD), is reported to be the key determinant of the cytotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f242446bf37ef1b37162aa38f3580d
https://doi.org/10.1111/j.1365-2125.2005.02472.x
https://doi.org/10.1111/j.1365-2125.2005.02472.x