Výsledky vyhledávání - "Toshihisa Hatae"

Electrolytic hydrogen-generating bottle supplies drinking water with free/combined chlorine and ozone repressed within safety standard under hydrogen-rich conditions

Autor: Nobuhiko Miwa, Toshihisa Hatae

Publikováno v: Medical Gas Research

Hydrogen molecules have attracted attention as a new antioxidant, but are left to be confirmedly verified whether the oral administration is highly safe or not, concurrently with retention of abundant hydrogen. When electrolysis was performed for 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9239427ac2313acb142ed25de091edd
http://europepmc.org/articles/PMC8130662

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Attenuation of interferon-γ mRNA expression in activated Jurkat T cells by exogenous zinc via down-regulation of the calcium-independent PKC–AP-1 signaling pathway

Autor: Satoshi Ishizuka, Kumiko Hayashi, Chieko Yokoyama, Toshihisa Hatae

Publikováno v: Life Sciences. 83:6-11

Zinc is known to modulate a wide variety of cellular functions including anti-inflammatory responses. We examined the intracellular signaling pathways that contribute to the regulation of interferon-gamma (IFN-gamma) by zinc in activated human Jurkat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9c221fe54bd3e289b47732e6c09051
https://doi.org/10.1016/j.lfs.2008.04.022

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Purification and Characterization of Recombinant Human Prostacyclin Synthase

Autor: Tadashi Tanabe, Masayuki Wada, Yoshio Imai, Manabu Shimonishi, Masahiko Nakamura, Toshihisa Hatae, Chieko Yokoyama, Volker Ullrich

Publikováno v: Journal of Biochemistry. 135:455-463

Prostacyclin synthase (PGIS), which catalyzes the conversion of prostaglandin (PG) H(2) to prostacyclin (PGI(2)), is a member of the cytochrome P-450 (P450) superfamily, CYP8A1. To study the enzymatic and protein characteristics of human PGIS, the en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be6bd543a0cdd2556345baeb4f13690
https://doi.org/10.1093/jb/mvh059

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Gene Transfer of Human Prostacyclin Synthase Prevents Neointimal Formation After Carotid Balloon Injury in Rats

Autor: T. Tsukahara, Ryuichi Morishita, Yasufumi Kaneda, T. Todaka, Chieko Yokoyama, Motokuni Aoki, Tadashi Tanabe, Toshio Ogihara, Toshihisa Hatae, Hiroji Yanamoto, Saburo Hara, N. Hashimoto, I. Nagata

Publikováno v: Stroke. 30:419-426

Background and Purpose —A disordered proliferative process in the vascular wall is thought to underlie the pathogenesis of restenosis after percutaneous transluminal angioplasty and carotid endarterectomy. A growth inhibitory property of overexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dea7fd84def367f6cab765efdb43043
https://doi.org/10.1161/01.str.30.2.419

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Site-directed mutagenesis of human prostacyclin synthase: Alteration of Cys441of the Cys-pocket, and Glu347and Arg350of the EXXR motif

Autor: Hiroyasu Inoue, Tomoko Yabuki, Chieko Yokoyama, Ta-i Tanabe, Toshihisa Hatae, Shuntaro Hara, Volker Ullrich

Publikováno v: FEBS Letters. 389:268-272

The possible active site Cys441 in the Cys-pocket and Glu347 and Arg350 of the EXXR motif of the human prostacyclin synthase, which catalyzes the conversion of prostaglandin H2 to prostacyclin, were subjected to site-directed mutagenesis in order to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008fa6d1c52bf43a124cced423331b9f
https://doi.org/10.1016/0014-5793(96)00600-x

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Heritable formation of neuroectodermal tumor in transgenic mice carrying the combined e1 region gene of adenovirus type 12 with the deregulated human renin promoter

Autor: Akiyoshi Fukamizu, Takesaburo Ogata, Hiroshi Kamma, Kazuo Murakami, Fumihiro Sugiyama, Ken-ichi Yagami, Hisashi Horiguchi, Masashi Sagara, Toshihisa Hatae, Yoichi Matsuda

Publikováno v: Journal of Cellular Biochemistry. 57:691-700

Adenovirus early 1 (E1) region gene products, including E1A and E1B, are required for transcriptional regulation of viral and cellular promoters in infected and transfected culture cells and for transformation of primary rodent cells. Here, we establ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6af8ee18e8694e28bcdbc0a3b50d412
https://doi.org/10.1002/jcb.240570414

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Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12

Autor: Takesaburo Ogata, Akiyoshi Fukamizu, Hiroshi Kamma, Toshihisa Hatae, Fumihiro Sugiyama, Hisashi Horiguchi, Ken-ichi Yagami, Kazuo Murakami, Masashi Sagara

Publikováno v: Journal of Biological Chemistry. 269:31252-31258

Adenovirus early 1 (E1) region gene products, including E1A and E1B, are required for transformation of primary cultured rodent cells. In order to investigate in vivo action of the E1 region, we established a line of transgenic mice carrying the onco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6200023c8f01c7efe9be77fa8d32a98b
https://doi.org/10.1016/s0021-9258(18)47416-9

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Comparative studies on species-specific reactivity between renin and angiotensinogen

Autor: Akiyoshi Fukamizu, Toshihisa Hatae, Eriko Takimoto, Kazuo Murakami

Publikováno v: Molecular and Cellular Biochemistry. 131:43-47

The renin-angiotensin system (RAS) is the most important regulator of electrolyte homeostasis and blood pressure. Our recently generated transgenic mice carrying either the human renin (hREN) or human angiotensinogen (hANG) genes did not develop hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35384ce3c5cab724660a3fbaccb592f2
https://doi.org/10.1007/bf01075723

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