Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Toshihisa B. Oyama"'
Autor:
Toshiya Masuda, Yasuo Oyama, Erika Hashimoto, Yoshimi Shingai, Aya Fujimoto, Kaori Kimura, Takuya Kawanai, Toshihisa B. Oyama, Kazuki Koizumi
Publikováno v:
Toxicology in Vitro. 24:1720-1726
Many effects of sesamol, an antioxidative constituent of sesame oil, have been reported for human health benefits due to its antioxidative action. However, we recently isolated two cytotoxic products, trimer and tetramer of sesamol, from oxidation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7395fe442b81e3312d56201c7ec74381
https://doi.org/10.1016/j.tiv.2010.05.013
https://doi.org/10.1016/j.tiv.2010.05.013
Autor:
Yasuo Oyama, Tomohiro M. Oyama, Keisuke Oyama, Shiro Ishida, Yoshiro Okano, Toshihisa B. Oyama
Publikováno v:
Toxicology in Vitro. 24:737-744
Polysorbate 80, a non-ionic surfactant, is used in the formula of water-insoluble anticancer agents for intravenous application. In our recent studies, this surfactant decreased cellular thiol content and the chemicals decreasing cellular thiol conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c3aa2d6ec0e210e651509be7167773
https://doi.org/10.1016/j.tiv.2010.01.004
https://doi.org/10.1016/j.tiv.2010.01.004
Autor:
Yasuo Oyama, T Ueha-Ishibashi, Toshihisa B. Oyama, Tomohiro M. Oyama, Yumiko Nishimura, Yoshiro Okano, Erika Hashimoto, Keisuke Oyama
Publikováno v:
Toxicology in Vitro. 23:1092-1099
Thimerosal (TMR), an ethylmercury-containing preservative in pharmaceutical products, was recently reported to increase intracellular Zn(2+) concentration. Therefore, some health concerns about the toxicity of TMR remain because of physiological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0364976b8b7d620b55a8a0f4789f434
https://doi.org/10.1016/j.tiv.2009.05.020
https://doi.org/10.1016/j.tiv.2009.05.020
Autor:
Takuya Kawanai, Erika Hashimoto, Toshihisa B. Oyama, Yasuo Oyama, Masaya Satoh, Keisuke Oyama, Tomohiro M. Oyama
Publikováno v:
Toxicology. 262:245-249
Effect of tri-n-butyltin (TBT), an environmental pollutant, on intracellular Zn(2+) concentration was tested in rat thymocytes to reveal one of cytotoxic profiles of TBT at nanomolar concentrations using a flow cytometer and appropriate fluorescent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf611b66be7fdcbb29ff4bcdd7fbc303
https://doi.org/10.1016/j.tox.2009.06.016
https://doi.org/10.1016/j.tox.2009.06.016
Autor:
Aya Fujimoto, Yumiko Nishimura, Toshiya Masuda, Toshihisa B. Oyama, Hiroko Matsui, Yoko Sakanashi, Yasuo Oyama
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 104:455-462
The chemopreventive and chemotherapeutic actions of polyphenols and related phenolics have received considerable attention since these compounds induce apoptosis in several types of cancer cells in vitro. A plausible criterion for the use of such com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8b2d91e719c1adf6633caf6de3cfdc
https://doi.org/10.1111/j.1742-7843.2009.00386.x
https://doi.org/10.1111/j.1742-7843.2009.00386.x
Autor:
Shoji Imai, Yumiko Nishimura, Yuki Matsuo, Toshihisa B. Oyama, Yoko Sakanashi, Yasuo Oyama, Tomohiro M. Oyama, Shiro Ishida, Yoshiro Okano
Publikováno v:
Toxicology in Vitro. 23:338-345
A23187, a calcium ionophore, is used to induce Ca(2+)-dependent cell death by increasing intracellular Ca(2+) concentration ([Ca(2+)](i)) under in vitro condition. Since this ionophore also increases membrane permeability of metal divalent cations su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caed610ee249d6ca2a74c4eb6603e66
https://doi.org/10.1016/j.tiv.2008.12.006
https://doi.org/10.1016/j.tiv.2008.12.006
Autor:
Yumiko Nishimura, Hiroko Matsui, Tomohiro M. Oyama, Toshihisa B. Oyama, Hitomi Sakai, Keisuke Oyama, Yasuo Oyama, Yoko Sakanashi
Publikováno v:
Life sciences. 83(5-6)
Quercetin is known to protect the cells suffering from oxidative stress. The oxidative stress elevates intracellular Ca 2+ concentration, one of the phenomena responsible for cell death. Therefore, we hypothesized that quercetin would protect the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690aa86b749e406f9f1e6431e98b9ee3
https://pubmed.ncbi.nlm.nih.gov/18586279
https://pubmed.ncbi.nlm.nih.gov/18586279
Autor:
Hiroko, Matsui, Yoko, Sakanashi, Tomohiro M, Oyama, Yasuo, Oyama, Shin-Ichi, Yokota, Shiro, Ishida, Yoshiro, Okano, Toshihisa B, Oyama, Yumiko, Nishimura
Publikováno v:
Toxicology. 248(2-3)
The use of zinc as a nutritional supplement has become common in many countries. Since zinc has diverse actions, it may be difficult to predict its synergistic and/or antagonistic action in simultaneous presence of drug(s). The combination of imidazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9489df58862087a7d1bfd1b6086b02dd
https://pubmed.ncbi.nlm.nih.gov/18468760
https://pubmed.ncbi.nlm.nih.gov/18468760
Autor:
Yumiko Nishimura, Yoshiro Okano, Yoko Sakanashi, Yasuo Oyama, Hiroko Matsui, Toshihisa B. Oyama, Tomohiro M. Oyama
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 22(4)
Quercetin, a flavonoid found in fruits and vegetables, exerts beneficial effects that contribute to human health. Therefore, quercetin preparation is expected as complementary or alternative medicine used by general population. The plausible criterio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f083b16421fac5c674ea90e0adcffd
https://pubmed.ncbi.nlm.nih.gov/18356015
https://pubmed.ncbi.nlm.nih.gov/18356015
Autor:
Keisuke Oyama, Midori Morimoto, Yoko Sakanashi, Yasuo Oyama, Tomohiro M. Oyama, Toshihisa B. Oyama, Hiroko Matsui
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 21(8)
In previous study, clotrimazole, an antifungal drug, exerted potent cytotoxic action on rat thymocytes in presence of metal divalent cations such as Cd(2+) and Pb(2+). To reveal one of toxicological characteristics of clotrimazole, we examined the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49f05ba18ce0396148c655ec090abdb
https://pubmed.ncbi.nlm.nih.gov/17703912
https://pubmed.ncbi.nlm.nih.gov/17703912