Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Toshihiro Oguma"'
Autor:
Ann-Lii Cheng, Jih-Hsiang Lee, Naoyuki Tajima, Shun-ichi Sasaki, Tomoko Ishizuka, Yu-Hsin Yen, Toshihiro Oguma, Masahiro Sugihara, Chia-Chi Lin, LiYin Lillian Chiu, Chih-Hung Hsu, Tom Wei-Wu Chen, James Chih-Hsin Yang
Publikováno v:
Investigational New Drugs
Summary Background Pexidartinib, a novel, orally administered small-molecule tyrosine kinase inhibitor, has strong selectivity against colony-stimulating factor 1 receptor. This phase I, nonrandomized, open-label multiple-dose study evaluated pexidar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a3957c4e9732cc4083907666fbdd19
https://doi.org/10.1007/s10637-019-00745-z
https://doi.org/10.1007/s10637-019-00745-z
Autor:
Takako Shimizu, Toshihiro Oguma, Hiroshi Masumoto, Nobutoshi Sugiyama, Satoshi Kunitada, Koichiro Ogata
Publikováno v:
Thrombosis Research. 135:594-601
Introduction Since Vitamin K antagonists are associated with various limitations such as narrow therapeutic window, slow onset and offset of effect, and numerous interactions with food and drugs, new oral anticoagulants targeted to inhibit thrombin o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0157f8117fa45f187e01d7c2e9227199
https://doi.org/10.1016/j.thromres.2014.12.028
https://doi.org/10.1016/j.thromres.2014.12.028
Autor:
Tadao Orii, Monica L. Gutiérrez, Amiko Hashimoto, Toshihiro Oguma, Shunji Tomatsu, Tatsuo Takahashi, William S. Sly, Adriana M. Montaño, Hirotaka Oikawa, Tsutomu Shimada, Vu Chi Dung
Publikováno v:
Molecular Genetics and Metabolism. 114:195-202
We treated mucopolysaccharidosis IVA (MPS IVA) mice to assess the effects of long-term enzyme replacement therapy (ERT) initiated at birth, since adult mice treated by ERT showed little improvement in bone pathology [1]. To conduct ERT in newborn mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220d16ed56a12ebd72022764978e5bbd
https://doi.org/10.1016/j.ymgme.2014.05.013
https://doi.org/10.1016/j.ymgme.2014.05.013
Autor:
Kazuhiro Kida, Tadashi Fujii, Yasuyuki Suzuki, Adriana M. Montaño, Miho Maeda, Hideyuki Futatsumori, Robert W. Mason, Tsutomu Shimada, Masaru Fukushi, Shunji Tomatsu, Yuniko Shibata, Tadao Orii, Seiji Yamaguchi, Toshihiro Oguma
Publikováno v:
Molecular Genetics and Metabolism. 110:42-53
article i nfo Mucopolysaccharidoses (MPS) are caused by deficiency of lysosomal enzyme activities needed to degrade glycos- aminoglycans (GAGs), which are long unbranched polysaccharides consisting of repeating disaccharides. GAGs include: chondroiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6872cd2c03c51a5b6ba33d59e57b6c9f
https://doi.org/10.1016/j.ymgme.2013.06.007
https://doi.org/10.1016/j.ymgme.2013.06.007
Autor:
Jeanne Mendell, Hiroshi Masumoto, Mohinder S. Bathala, Toshihiro Oguma, Ling He, Chris Lowrie
Publikováno v:
Drug Metabolism and Disposition. 40:2250-2255
This study determined the mass balance and pharmacokinetics of edoxaban in humans after oral administration of [¹⁴C]edoxaban. After oral administration of 60 mg (as active moiety) of [¹⁴C]edoxaban to six healthy male subjects, serial blood/plas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a89b93550946ef53f9eb8d8391a1c2
https://doi.org/10.1124/dmd.112.046888
https://doi.org/10.1124/dmd.112.046888
Autor:
Hirotaka Oikawa, Tadao Orii, Kazuhiro Kida, Mitsuru Kubota, Adriana M. Montaño, Shunji Tomatsu, Luis A. Barrera, Seiji Yamaguchi, Vu Chi Dung, Toshihiro Oguma, Yasuyuki Suzuki, María L. Gutiérrez, Masaru Fukushi
Publikováno v:
Molecular Genetics and Metabolism. 99:124-131
Glycosaminoglycans (GAGs) are accumulated in various organs in both mucopolysaccharidoses (MPS) and mucolipidoses II and III (ML II and III). MPS and ML II and III patients can not properly degrade dermatan sulfate (DS) and/or heparan sulfate (HS). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3d0e8e14c687e1c7efd0e881d13d6f
https://doi.org/10.1016/j.ymgme.2009.10.001
https://doi.org/10.1016/j.ymgme.2009.10.001
Publikováno v:
Analytical Biochemistry. 368:79-86
We established a highly sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method to analyze the disaccharides produced from keratan sulfate (KS), heparan sulfate (HS), and dermatan sulfate (DS). It was revealed that KS, HS, and DS i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68821104543c97f6a2839c31288409ac
https://doi.org/10.1016/j.ab.2007.05.016
https://doi.org/10.1016/j.ab.2007.05.016
Publikováno v:
Biomedical Chromatography. 19:19-26
DE-310 is a macromolecular carrier conjugate containing an anti-tumor camptothecin derivative, DX-8951, which is conjugated to a water-soluble polymer via a peptide spacer. Assay methods have been developed for the determination of a polymer-bonded D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c06098a91855bc6051353fe5861bb3
https://doi.org/10.1002/bmc.409
https://doi.org/10.1002/bmc.409
Publikováno v:
Analytical Biochemistry. 290:68-73
We established a highly sensitive LC/MS/MS method for the analysis of the disaccharides produced from keratan sulfates (KS). It was revealed that the disaccharides produced by keratanase II enzymatic digestion of KS could be determined with high sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9f6d8c191c03f0fe0d062d65e72cad
https://doi.org/10.1006/abio.2000.4940
https://doi.org/10.1006/abio.2000.4940
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:176-180
A sensitive high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of lactone and total drug (lactone plus hydroxy-acid) of DX-8951 in mouse plasma. Solid-phase extraction by C18 cartridge separat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d85aa4c2ea57854fbd884feb6c5f9f
https://doi.org/10.1248/bpb.24.176
https://doi.org/10.1248/bpb.24.176