Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Toshihiro Mitaka"'
Autor:
Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Background Small hepatocyte-like progenitor cells (SHPCs) are hepatocytic progenitor cells that transiently form clusters in rat livers treated with retrorsine (Ret) that underwent 70% partial hepatectomy (PH). We previously reported that tr
Externí odkaz:
https://doaj.org/article/01027d70d36941d085c6de300533cc09
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Intrahepatic nerves are involved in the regulation of metabolic reactions and hepatocyte-based regeneration after surgical resection, although their contribution to chronic liver injury remains unknown. Given that intrahepatic nerves are abu
Externí odkaz:
https://doaj.org/article/79286e99bcc040b695a0f557fee95faf
Publikováno v:
Cells, Vol 12, Iss 23, p 2718 (2023)
Mature hepatocytes (MHs) in an adult rodent liver are categorized into the following three subpopulations based on their proliferative capability: type I cells (MH-I), which are committed progenitor cells that possess a high growth capability and bas
Externí odkaz:
https://doaj.org/article/41c550155d9a41a89f83d483244f7f9c
Autor:
Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, Atsushi Miyajima, Toshihiro Mitaka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Combining mouse hepatocyte progenitors and cholangiocytes ex vivo, the authors form an organoid that can drain bile ex vivo and transport metabolites, as in the liver.
Externí odkaz:
https://doaj.org/article/5ae34e70df8044cf9ed9cd6e6564d196
Autor:
Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract Background Small hepatocyte-like progenitor cells (SHPCs) appear to form transient clusters in rat livers treated with retrorsine (Ret) and 70% partial hepatectomy (PH). We previously reported that the expansion of SHPCs was amplified in Ret
Externí odkaz:
https://doaj.org/article/4f2f21a54c56413b8054c6b0689d060c
Autor:
Junichi Kino, Norihisa Ichinohe, Masayuki Ishii, Hiromu Suzuki, Toru Mizuguchi, Naoki Tanimizu, Toshihiro Mitaka
Publikováno v:
Hepatology Communications, Vol 4, Iss 1, Pp 21-37 (2020)
In this study, we investigated how the ability of hepatocytic parental progenitor cells (HPPCs) to self‐renew can be maintained and how laminin (LN) isoforms play an important role in their self‐renewal and maturation. Hepatocytes isolated from a
Externí odkaz:
https://doaj.org/article/9a8dd347541b4e9e8270be2ff65b7efd
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 3, Iss 2, Pp 235-248 (2008)
Vertical cell-cell contact is an important difference between 2D- and 3D-culture models. We hypothesized that this difference in cell-cell contacts is critical in maintaining hepatocyte functions. Here we developed a simple culture technique to inves
Externí odkaz:
https://doaj.org/article/277e432f85b442bb9781958f8f01cb1b
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 3, Iss 2, Pp 249-262 (2008)
Cell response on microporous membranes is important since the membranes are often used for the applications of tissue engineering. We previously developed the 3D stacked-up culture of hepatic progenitor cells, which are small hepatocytes (SHs), where
Externí odkaz:
https://doaj.org/article/614f088a53d24c0d9fe8cee7b39d7e23
Autor:
Yukio Nakamura, Toru Mizuguchi M.D., Ph.D, Naoki Tanimizu, Norihisa Ichinohe, Hidekazu Ooe, Masaki Kawamoto, Makoto Meguro, Koichi Hirata, Toshihiro Mitaka
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Liver failure after liver resection for cirrhosis is a critical problem, and no effective therapy except liver transplantation is currently available. The objective of this study was to examine whether hepatocyte transplantation (HT) reduces the post
Externí odkaz:
https://doaj.org/article/1cfe63f892964734847667d40bb2a960
Autor:
Norihisa Ichinohe, Junko Kon, Kazunori Sasaki, Yukio Nakamura, Hidekazu Ooe, Naoki Tanimizu, Toshihiro Mitaka M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Cell-based therapies as an alternative to liver transplantation have been anticipated for the treatment of potentially fatal liver diseases. Not only mature hepatocytes (MHs) but also hepatic stem/progenitor cells are considered as candidate cell sou
Externí odkaz:
https://doaj.org/article/89849a335fd643bfb93dc741e1ace6f2