Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Toshihiro Kitamoto"'
Autor:
Hung-Lin Chen, Junko Kasuya, Patrick Lansdon, Garrett Kaas, Hanxi Tang, Maggie Sodders, Toshihiro Kitamoto
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 4, Pp 1327-1340 (2020)
Voltage-gated sodium (Nav) channels play a central role in the generation and propagation of action potentials in excitable cells such as neurons and muscles. To determine how the phenotypes of Nav-channel mutants are affected by other genes, we perf
Externí odkaz:
https://doaj.org/article/f5ab4e7a195444719b5afd416a7dde6d
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001459 (2021)
Memory is initially labile but can be consolidated into stable long-term memory (LTM) that is stored in the brain for extended periods. Despite recent progress, the molecular and cellular mechanisms underlying the intriguing neurobiological processes
Externí odkaz:
https://doaj.org/article/035e47ca6c594ad7a409771a50b37548
Autor:
Samantha J. Hindle, Roeben N. Munji, Elena Dolghih, Garrett Gaskins, Souvinh Orng, Hiroshi Ishimoto, Allison Soung, Michael DeSalvo, Toshihiro Kitamoto, Michael J. Keiser, Matthew P. Jacobson, Richard Daneman, Roland J. Bainton
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1304-1316 (2017)
Summary: Central nervous system (CNS) chemical protection depends upon discrete control of small-molecule access by the blood-brain barrier (BBB). Curiously, some drugs cause CNS side-effects despite negligible transit past the BBB. To investigate th
Externí odkaz:
https://doaj.org/article/ab536355a3d44a6c8f5909e9d8116224
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137758 (2015)
Despite an established link between epilepsy and sleep behavior, it remains unclear how specific epileptogenic mutations affect sleep and subsequently influence seizure susceptibility. Recently, Sun et al. (2012) created a fly knock-in model of human
Externí odkaz:
https://doaj.org/article/c9ca6ffd8661435ca12c14cfed88320d
Autor:
Takaomi Sakai, Kazuki Watanabe, Hirono Ohashi, Shoma Sato, Show Inami, Naoto Shimada, Toshihiro Kitamoto
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88175 (2014)
In a variety of animal species, females hold a leading position in evaluating potential mating partners. The decision of virgin females to accept or reject a courting male is one of the most critical steps for mating success. In the fruitfly Drosophi
Externí odkaz:
https://doaj.org/article/3ed4393c876648ec9e2963905eed7eb2
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003843 (2013)
The biological actions of steroid hormones are mediated primarily by their cognate nuclear receptors, which serve as steroid-dependent transcription factors. However, steroids can also execute their functions by modulating intracellular signaling cas
Externí odkaz:
https://doaj.org/article/b3922400a3044f7099cbcc58d01127d9
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 2 (2009)
The fruit fly Drosophila melanogaster is an excellent model organism to identify genes and genetic pathways important for learning and memory. However, its small size makes surgical treatment and electrophysiological manipulation technically difficul
Externí odkaz:
https://doaj.org/article/c5ed20be311d439997ba7c37fef75f89
Publikováno v:
SSRN Electronic Journal.
Autor:
Maggie Sodders, Hung-Lin Chen, Toshihiro Kitamoto, Junko Kasuya, Garrett A. Kaas, Hanxi Tang, Patrick Lansdon
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 4, Pp 1327-1340 (2020)
Voltage-gated sodium (Nav) channels play a central role in the generation and propagation of action potentials in excitable cells such as neurons and muscles. To determine how the phenotypes of Nav-channel mutants are affected by other genes, we perf
Publikováno v:
J Neurogenet
Organisms respond to various environmental stressors by modulating physiology and behavior to maintain homeostasis. Steroids and catecholamines are involved in the highly conserved signaling pathways crucial for mounting molecular and cellular events