Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Toshihiro Imaeda"'
Autor:
Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Vitaly Kuryavyi, Tasos Gogakos, Joshua I. Steinberg, Michael Miller, Lavoisier Ramos-Espiritu, Yasutomi Asano, Shogo Hashizume, Jumpei Aida, Toshihiro Imaeda, Rei Okamoto, Andy J. Jennings, Mayako Michino, Takanobu Kuroita, Andrew Stamford, Pu Gao, Peter Meinke, J. Fraser Glickman, Dinshaw J. Patel, Thomas Tuschl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cyclic GMP-AMP synthase (cGAS) is involved in the modulation of inflammatory responses. Here, the authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in inte
Externí odkaz:
https://doaj.org/article/6f06ae155ca2436dab39b0d693daf384
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Upon DNA binding cyclic GMP-AMP synthase (cGAS) produces a cyclic dinucleotide, which leads to the upregulation of inflammatory genes. Here the authors develop small molecule cGAS inhibitors, functionally characterize them and present the inhibitor a
Externí odkaz:
https://doaj.org/article/2885ccbed5fa465f9f9e037a1d7866c1
Autor:
Jessica Vincent, Carolina Adura, Pu Gao, Antonio Luz, Lodoe Lama, Yasutomi Asano, Rei Okamoto, Toshihiro Imaeda, Jumpei Aida, Katherine Rothamel, Tasos Gogakos, Joshua Steinberg, Seth Reasoner, Kazuyoshi Aso, Thomas Tuschl, Dinshaw J. Patel, J. Fraser Glickman, Manuel Ascano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
The previously published version of this Article contained errors in Fig. 6. In panel h the units of the x axis were incorrectly given as mM and should have been given as µM. Also, the IC50s for RU.365, RU.332 and RU.521 within panel h were incorrec
Externí odkaz:
https://doaj.org/article/920c5aa0d55044bb8e7799f3d44a9730
Autor:
Hiroshi Yukitake, Haruhide Kimura, Hirobumi Suzuki, Yasukazu Tajima, Yoshimi Sato, Toshihiro Imaeda, Masahiro Kajino, Masayuki Takizawa
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23256 (2011)
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that are primarily represented by ulcerative colitis and Crohn's disease. The etiology of IBD is not well understood; however, oxidative stress is considered a potential et
Externí odkaz:
https://doaj.org/article/24387a9aa18b421b94b810b89e2b9c73
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Annie Leung, Yi J. Liu, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Mayako Michino, Takafumi Yukawa, Sevil Chelebieva, Patrick K. Tumwebaze, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Philip J. Rosenthal, Roland A. Cooper, Nigel Liverton, Michael Foley, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 66:1484-1508
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::396cefbba4bbff5c41d426f4caafe461
https://doi.org/10.1021/acs.jmedchem.2c01651
https://doi.org/10.1021/acs.jmedchem.2c01651
Autor:
Hao Zhang, John Ginn, Wenhu Zhan, Yi J. Liu, Annie Leung, Akinori Toita, Rei Okamoto, Tzu-Tshin Wong, Toshihiro Imaeda, Ryoma Hara, Takafumi Yukawa, Mayako Michino, Jeremie Vendome, Thijs Beuming, Kenjiro Sato, Kazuyoshi Aso, Peter T. Meinke, Carl F. Nathan, Laura A. Kirkman, Gang Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:9350-9375
With over 200 million cases and close to half a million deaths each year, malaria is a threat to global health, particularly in developing countries.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b58c6b8b4be75e0e7350e808c708fd6
https://doi.org/10.1021/acs.jmedchem.2c00611
https://doi.org/10.1021/acs.jmedchem.2c00611
Autor:
Shoshanna C. Kahne, Tierra Ouellette, Priya Saha, Huilin Li, Michael Foley, Toshihiro Imaeda, Kazuyoshi Aso, Ryoma Hara, K. Heran Darwin, Carl Nathan, Masanori Kawasaki, Akinori Toita, Wenhu Zhan, Francesca Moraca, Gang Lin, Jeremie Vendome, Takafumi Yukawa, John Ginn, Xiuju Jiang, Mayako Michino, Kenjiro Sato, Peter T. Meinke, Hao Zhang, Kristin Burns-Huang, Rei Okamoto, Tzu-Tshin Wong, Hao-Chi Hsu
Publikováno v:
Journal of Medicinal Chemistry. 64:6262-6272
Treatment of tuberculosis (TB) currently takes at least 6 months. Latent Mycobacterium tuberculosis (Mtb) is phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill nonreplicating (NR) Mtb may shorten treatment when us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ac426b4c19d0fdaa3f695a2619ad2e
https://doi.org/10.1021/acs.jmedchem.1c00296
https://doi.org/10.1021/acs.jmedchem.1c00296
Autor:
Toshio Tanaka, Tomohiro Kawamoto, Satoshi Endo, Samuel Aparicio, Michiko Tawada, Atsushi Nakanishi, Momoko Ohori, Douglas R. Cary, Masahiro Ito, Masahiro Nogami, Toshihiro Imaeda, Misa Iwatani, Shinsuke Araki, Shoichi Nakao, Yasuhiro Imaeda
Publikováno v:
Biochemical and Biophysical Research Communications. 523:795-801
The DEAD-box family of RNA helicases plays essential roles in both transcriptional and translational mRNA degradation; they unwind short double-stranded RNA by breaking the RNA-RNA interactions. Two DEAD-box RNA helicases, eukaryotic translation init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92b4a687affd66801c43aa881d530cd
https://doi.org/10.1016/j.bbrc.2019.12.094
https://doi.org/10.1016/j.bbrc.2019.12.094
Autor:
Takafumi Yukawa, Tohru Yamashita, Toshihiro Imaeda, Hiroyuki Kakei, Shogo Hashizume, Minoru Nakamura, Masaki Daini, Atsutoshi Okabe, Kosuke Nakashima, Akina Harada, Naohiro Narita, Ezio Bettini, Annarosa Ugolini, Mauro Corsi, Tomoaki Hasui
Publikováno v:
Bioorganic & Medicinal Chemistry. 79:117150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdaa42f4240970b64eb376ef2c178348
https://doi.org/10.1016/j.bmc.2022.117150
https://doi.org/10.1016/j.bmc.2022.117150
Autor:
Trevor Morgan, Kazuyoshi Aso, Huilin Li, Wenhu Zhan, Gang Lin, Tierra Ouellette, Peter T. Meinke, Carl Nathan, Manoj K. Ramjee, Adrian G. Wright, Hao-Chi Hsu, Toshihiro Imaeda, Mayako Michino, Kenjiro Sato, Kristin Burns-Huang, Ryoma Hara, Michael Foley, Rei Okamoto
Publikováno v:
Journal of Medicinal Chemistry. 62:9246-9253
Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-impos...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04bac3c504e9295cab53b06b52750141
https://doi.org/10.1021/acs.jmedchem.9b01187
https://doi.org/10.1021/acs.jmedchem.9b01187