Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Toshihiro, Unno"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 134, Iss 1, Pp 55-58 (2017)
Cognitive impairment often occurs in Parkinson's disease (PD), but the mechanism of onset remains unknown. Recently, we reported that PD model mice produced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show facilitation of hippocampal memor
Externí odkaz:
https://doaj.org/article/0f98c31a3ac949bdbfa4ccc356c2cf61
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 926 (2021)
Parasympathetic signalling via muscarinic acetylcholine receptors (mAChRs) regulates gastrointestinal smooth muscle function. In most instances, the mAChR population in smooth muscle consists mainly of M2 and M3 subtypes in a roughly 80% to 20% mixtu
Externí odkaz:
https://doaj.org/article/5662873657264800ac6a61868551aca4
Autor:
Kiattisak PIMPJONG, Hayato MATSUYAMA, Taichi MIZUTANI, Yasuyuki TANAHASHI, Toshio OHTA, Toshihiro UNNO
Publikováno v:
Journal of Veterinary Medical Science.
Autor:
Hayato Matsuyama, Yasuyuki Tanahashi, Takio Kitazawa, Masahisa Yamada, Seiichi Komori, Toshihiro Unno
Publikováno v:
Journal of Pharmacological Sciences, Vol 121, Iss 3, Pp 227-236 (2013)
Cholinergic nerve–mediated excitatory junction potentials (EJPs) in the longitudinal muscle of mouse ileum were characterized by using M2 or M3 muscarinic receptor–knockout (KO) mice and 1-[β-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-i
Externí odkaz:
https://doaj.org/article/826452b6693849e3ad000c4dd5d1b43a
Autor:
Masayuki Yamamoto, Toshihiro Unno, Noriko Inasaki, Yasuyuki Tanahashi, Mai Uchiyama, Taisuke Katsurada, Seiichi Komori, Hayato Matsuyama, Takashi Sakamoto
Publikováno v:
American Journal of Physiology-Cell Physiology. 318:C514-C523
In mouse ileal myocytes, muscarinic receptor-mediated cationic current ( mIcat) occurs mainly through synergism of M2 and M3 subtypes involving Gi/o-type GTP-binding proteins and phospholipase C (PLC). We have further studied the M2/M3 synergistic pa
Autor:
Masayuki Yamamoto, Toshihiro Unno, Hayato Matsuyama, Masanobu Kohda, Noriyuki Masuda, Masakazu Nishimura, Toshiaki Ishii, Seiichi Komori
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 3, Pp 248-257 (2008)
The present study, aiming to elucidate ion channel mechanisms underlying muscarinic receptor–induced depolarization, has characterized membrane currents induced by carbachol in single guinea-pig urinary bladder myocytes. Application of carbachol to
Externí odkaz:
https://doaj.org/article/1a0ff9e43bb0485ea7f11165bff84c1e
Autor:
Takashi Sakamoto, Toshihiro Unno, Hayato Matsuyama, Mai Uchiyama, Mitsunobu Hattori, Masakazu Nishimura, Seiichi Komori
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 3, Pp 215-226 (2006)
Abstract.: In mouse intestinal smooth muscle cells held at −50 mV, carbachol evoked an atropine-sensitive inward current in the intracellular presence of Cs+. The current response consisted of an initial peak followed by a smaller plateau component
Externí odkaz:
https://doaj.org/article/54a24da88491409bb6ed4dedf34bf739
Autor:
Hiroyuki Okamoto, Toshihiro Unno, Daisuke Arima, Maki Suzuki, Hai-Dun Yan, Hayato Matsuyama, Masakazu Nishimura, Seiichi Komori
Publikováno v:
Journal of Pharmacological Sciences, Vol 95, Iss 2, Pp 203-213 (2004)
In guinea pig single ileal smooth muscle cells held under voltage-clamp, the role of phospholipase C (PLC) in activation of the muscarinic receptor-operated cationic current (Icat) was studied. U73122, a PLC inhibitor, prevented the generation of Ica
Externí odkaz:
https://doaj.org/article/4ab82f32eaa84d7fa88438a43c52acc1
Autor:
Hirokazu Tsubone, Hirotaka Tomiyasu, Taiki Mihara, Masatoshi Hori, Tong-Rong Jan, Yasuyuki Tanahashi, H. Kimura, Yuki Imura, Noriyuki Kaji, Koichi Ohno, Hiroshi Ozaki, Toshihiro Unno
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Gastrointestinal prokinetic agents function as serotonin-4 receptor (5-HT4R) agonists to activate myenteric plexus neurons to release acetylcholine (ACh), which then induce anti-inflammatory action. Details of this pathway, however, remain unknown. T
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 926, p 926 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 926, p 926 (2021)
Parasympathetic signalling via muscarinic acetylcholine receptors (mAChRs) regulates gastrointestinal smooth muscle function. In most instances, the mAChR population in smooth muscle consists mainly of M2 and M3 subtypes in a roughly 80% to 20% mixtu