Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Toshihiro, Seike"'
Autor:
Yukimasa Shiotsu, Shiro Soga, Shiro Akinaga, Yutaka Kanda, Hiroshi Nakagawa, Toshihiro Seike, Hisashi Tagaya, Toshihiko Ishii, Takayuki Nakashima
Supplementary Data from New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eac44feed9bb3a0c2e4e510ae4018f
https://doi.org/10.1158/1078-0432.22442663
https://doi.org/10.1158/1078-0432.22442663
Autor:
Yukimasa Shiotsu, Shiro Soga, Shiro Akinaga, Yutaka Kanda, Hiroshi Nakagawa, Toshihiro Seike, Hisashi Tagaya, Toshihiko Ishii, Takayuki Nakashima
Purpose: The heat shock protein 90 (Hsp90) plays an important role in chaperoning oncogenic client proteins in multiple myeloma (MM) cells, and several Hsp90 inhibitors have shown antitumor activities both in vitro and in vivo. However the precise me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b9b7f93cb765894d34df7b7b1e20ec
https://doi.org/10.1158/1078-0432.c.6519338
https://doi.org/10.1158/1078-0432.c.6519338
Autor:
Hiroji Iwata, Rikiya Nakamura, Norikazu Masuda, Toshinari Yamashita, Yutaka Yamamoto, Kokoro Kobayashi, Junji Tsurutani, Tsutomu Iwasa, Kan Yonemori, Kenji Tamura, Tomoyuki Aruga, Eriko Tokunaga, Koji Kaneko, Min-Jung Lee, Akira Yuno, Azusa Kawabata, Toshihiro Seike, Ayumi Kaneda, Yozo Nishimura, Jane B Trepel, Shigehira Saji
Publikováno v:
Japanese journal of clinical oncology. 53(1)
Background We aimed to confirm the efficacy and safety of the oral histone deacetylase inhibitor entinostat in Japanese patients with hormone receptor-positive advanced/recurrent breast cancer and to explore potential biomarkers. Methods This phase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901bd318b85e3b8bbf921995ef982aab
https://pubmed.ncbi.nlm.nih.gov/36398439
https://pubmed.ncbi.nlm.nih.gov/36398439
Autor:
Ayumi, Kaneda, Toshihiro, Seike, Tomohiro, Danjo, Takahiro, Nakajima, Nobumasa, Otsubo, Daisuke, Yamaguchi, Yoshiro, Tsuji, Kaori, Hamaguchi, Mai, Yasunaga, Yoichi, Nishiya, Michihiko, Suzuki, Jun-Ichi, Saito, Rie, Yatsunami, Satoshi, Nakamura, Yoshitaka, Sekido, Kiyotoshi, Mori
Publikováno v:
Am J Cancer Res
The Hippo signaling pathway regulates cell fate and organ development. In the Hippo pathway, transcriptional enhanced associate domain (TEAD) which is a transcription factor is activated by forming a complex with yes-associated protein 1 (YAP1) or tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b9cd2e0dae781e69fc45755972dc3ea
https://pubmed.ncbi.nlm.nih.gov/33415007
https://pubmed.ncbi.nlm.nih.gov/33415007
Autor:
Kyota Fujita, Toshihiro Seike, Noriko Yutsudo, Mizuki Ohno, Hidetaka Yamada, Hiroo Yamaguchi, Kunihiko Sakumi, Yukiko Yamakawa, Mizuho A Kido, Atsushi Takaki, Toshihiko Katafuchi, Yoshinori Tanaka, Yusaku Nakabeppu, Mami Noda
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7247 (2009)
It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson's disease (PD).
Externí odkaz:
https://doaj.org/article/42ade39195834d1b9ef5b9e82b855a6b
Autor:
Toshihiko Ishii, Mai Yasunaga, Kaori Hamaguchi, Daisuke Yamaguchi, Ayumi Kaneda, Yoichi Nishiya, Nobumasa Otsubo, Michihiko Suzuki, Tomohiro Danjo, Tomoko Hamada, Kensuke Aida, Yoshiro Tsuji, Takeshi Uemori, Ryuichiro Nakai, Takahiro Nakajima, Toshihiro Seike, Kensuke Myojo, Hideyuki Onodera, Jun-Ichi Saito
Publikováno v:
Cancer Research. 79:3086-3086
Objective: Hippo signaling pathway is known to regulate organ development. In Hippo signaling pathway, YAP or TAZ works as a transcriptional co-activator and forms a transcriptional complex with TEAD. In several cancers, upstream factors in Hippo pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a303092c948a990744890cb69c81408f
https://doi.org/10.1158/1538-7445.am2019-3086
https://doi.org/10.1158/1538-7445.am2019-3086
Autor:
Megumi Yamafuji, Kyota Fujita, Haruhiro Higashida, Toshihiro Seike, Nozomi Akimoto, Mami Noda, Shigeru Yokoyama, Yuko Kamiyama, Mizuho A. Kido
Publikováno v:
Messenger. 2:54-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71626dfa5c3850495e38307dd2947e75
https://doi.org/10.1166/msr.2013.1021
https://doi.org/10.1166/msr.2013.1021
Publikováno v:
Neuroscience and Behavioral Physiology. 41:243-251
Following any type of brain injury such as lesion, stroke, and tumor/cancer invasion, microglia are rapidly activated and recruited to the site of injury. Microglia is the main immune effector cell population of the central nervous system and control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ef0f6422b91562ad11f1c6f2001e832
https://doi.org/10.1007/s11055-011-9406-9
https://doi.org/10.1007/s11055-011-9406-9
Autor:
Kiyofumi Yamada, Takashi Torashima, Sumiko Mochida, Toshio Munesue, Mohammad Saharul Islam, Olga Lopatina, Kazuhiro Higashida, Akihiro Matsushima, Minako Hashii, Alla B. Salmina, Haruhiro Higashida, Toru Yoshihara, Natalia A. Shnayder, Ichiro Kato, Shin Takasawa, Hirokazu Hirai, Nobuaki Yamada, Naoya Noguchi, Mami Noda, Kenshi Hayashi, Shigenori Tanaka, Shigeru Yokoyama, Taku Nagai, Masahide Asano, Yoshitake Shiraishi, Nobuaki Shimizu, Toshihiro Seike, Keita Koizumi, Duo Jin, Hong-Xiang Liu, Kyota Fujita, Hiroshi Okamoto
Publikováno v:
Nature. 446:41-45
CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8975ce0cd16ac4507f5f83fa187bbc
https://doi.org/10.1038/nature05526
https://doi.org/10.1038/nature05526
Autor:
Simone Juliger, Yukimasa Shiotsu, Simon P. Joel, Lenushka Maharaj, Takayuki Nakashima, Toshihiro Seike, James D. Cavenagh, Shiro Soga, Toshihiko Ishii, Shiro Akinaga
Publikováno v:
Blood Cancer Journal
Heat shock protein 90 (Hsp90) is a promising target for anti-tumor therapy. We previously reported the anti-tumor activity of a novel Hsp90 inhibitor, KW-2478, in multiple myeloma (MM) as a single agent. In this study, we examined the combinational e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c767fd69cf1d2658dccd5e1ad800201c
https://pubmed.ncbi.nlm.nih.gov/22829970
https://pubmed.ncbi.nlm.nih.gov/22829970