Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Toshihiko Yanagisawa"'
Autor:
Yujiro Kobayashi, Seiichi Iizuka, Wataru Suzuki, Kazuaki Takahashi, Mitsunobu Nagata, Masanao Kanitani, Yoshio Kase, Toshihiko Yanagisawa, Masaki Aburada, Shuichi Takeda, Sachiko Imamura, Masahiro Tabuchi
Publikováno v:
Experimental Animals. 54:71-83
The TSOD mouse has been established as an inbred strain with spontaneous development of diabetes mellitus as the first clinical signs of diabetes. Polydipsia and polyuria are observed at about 2 months old only in male mice, after which hyperglycemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af7553da4edf5727784145592eac67e
https://doi.org/10.1538/expanim.54.71
https://doi.org/10.1538/expanim.54.71
Publikováno v:
The Proceedings of the Machine Design and Tribology Division meeting in JSME. :29-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48604c66b7d014be2245aa585080bbd
https://doi.org/10.1299/jsmemdt.2003.3.29
https://doi.org/10.1299/jsmemdt.2003.3.29
Autor:
Kazuhisa Ishihara, Yuichi Fujii, Hirakura Kazuhiro, Hideo Kamei, Junko Watanabe, Mamoru Yamashita, Chiharu Sadakane, Toshihiko Yanagisawa, Yoko Wakui, Takayuki Asano, Takemi Yoshida, Masayuki Kimura
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 27:29-35
The metabolism of cephaeline and emetine, which are the primary active components of ipecac syrup, were investigated in rats. Cephaeline-6'-O-glucuronide was found to be a biliary metabolite of cephaeline. Cephaeline (6'-O-demethylemetine) and 9-O-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbc7a0470b2fa9750962ab17b5ca65b
https://doi.org/10.1007/bf03190402
https://doi.org/10.1007/bf03190402
Autor:
Shunichi Maemura, Hikaru Tanaka, Tadaomi Kadota, Tomoyuki Shirai, Mayumi Kawabe, Akihiro Hagiwara, Nobuyuki Ito, Seiko Tamano, Toshihiko Yanagisawa, Masashi Sano
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 22:41-50
The modifying potential of two Kampo medicines (Japanese traditional herbal medicines), Sho-saiko-to (TJ-9) and Sairei-to (TJ-114), on urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)- nitrosamine (BBN) was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec23401e0bd7e609e497436e92141b13
https://doi.org/10.1002/tcm.1037
https://doi.org/10.1002/tcm.1037
Autor:
Masayuki Kimura, Takayuki Asano, Toshihiko Yanagisawa, Chiharu Sadakane, Kazuhisa Ishihara, Hideo Kamei
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 757:197-206
A high-performance liquid chromatographic assay method for the quantitation of ipecac alkaloids (cephaeline and emetine) in human plasma and urine is described. Human plasma or urine was extracted with diethylether under alkaline conditions following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a4c3b3d4d533771919d2248b9fedc6
https://doi.org/10.1016/s0378-4347(01)00170-0
https://doi.org/10.1016/s0378-4347(01)00170-0
Autor:
Hideo Kamei, Masayuki Kimura, Takayuki Asano, Hirotaka Kushida, Takemi Yoshida, Toshihiko Yanagisawa, Kazuhisa Ishihara, Yoko Wakui, Chiharu Sadakane
Publikováno v:
Biological and Pharmaceutical Bulletin. 24:678-682
In this study, we identified the metabolites and the CYP forms that are specifically involved in emetine O-demethylation in human liver microsomes, and cleared the inhibitory potential of cephaeline and emetine on the activity of the major drug-metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a4b8b125b5492f30a17f2bbfc8f591
https://doi.org/10.1248/bpb.24.678
https://doi.org/10.1248/bpb.24.678
Autor:
Hiromi Sasaki, Toru Endo, Dianne M. Creasy, Minoru Okada, Shunichi Maemura, Toshihiko Yanagisawa, Philip W. East, David M. Virgo
Publikováno v:
The Journal of Toxicological Sciences. 23:619-642
Triethylenetetramine dihydrochloride (trientine-2HCl, TJA-250), a copper chelating agent used to treat Wilson's disease, was administered orally to male and female F-344 rats for 4 or 8 weeks at dosages of 0, 100, 350 or 1200 mg/kg/day or for 26 week
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3915fb4b6d64086a94f2c7c0cecafa9b
https://doi.org/10.2131/jts.23.supplementiv_619
https://doi.org/10.2131/jts.23.supplementiv_619
Autor:
Yuki Okui, Masao Maruno, Kazunori Hashimoto, Tetsuro Fujita, Toshihiko Yanagisawa, Yukinobu Ikeya
Publikováno v:
Planta Medica. 60:124-127
The methanolic extract of the roots of Asiasarum sieboldi has been evaluated for anti-allergic effects on various experimental models in vitro and in vivo. Bioassay-guided fractionation of the methanolic extract resulted in isolation of suppressive c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60887e0cfb379117910863006a7c065
https://doi.org/10.1055/s-2006-959432
https://doi.org/10.1055/s-2006-959432
Autor:
Masao, Toshitsugu Sato, Yuka Okui, Kunio Hosaka, Yoshihiro Hasegawa, Hiroshi Mitsuhashi, Toshihiko Yanagisawa
Publikováno v:
ChemInform. 23
2,4-Diamino-[E]-6-[2-(3-pyridyl)ethenyl]-1,3,5-triazine (3a), leukotriene C4 (LTC4) antagonist, was found to possess a protective effect on HCl.ethanol-induced gastric lesions. Analogues of 3a were synthesized and evaluated for the effect as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b159d78d7cad7688dd78e92c28f61f3
https://doi.org/10.1002/chin.199242186
https://doi.org/10.1002/chin.199242186
Publikováno v:
Traditional Herbal Medicines for Modern Times ISBN: 9780415308304
Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications
Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a56b8cf64eefa7d92da21dfe9a65c4d2
https://doi.org/10.1201/9781420023510.ch11
https://doi.org/10.1201/9781420023510.ch11
