Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Toshihiko Toyofuku"'
Autor:
Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, Shuichiro Higo, Nagako Sougawa, Maki Takeda, Takuji Kawamura, Ryohei Matsuura, Daisuke Okuzaki, Toshihiko Toyofuku, Yoshiki Sawa, Li Liu, Shigeru Miyagawa
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108992- (2024)
Summary: Human iPSC-derived cardiomyocytes (hiPSC-CMs) exhibit functional immaturity, potentially impacting their suitability for assessing drug proarrhythmic potential. We previously devised a traveling wave (TW) system to promote maturation in 3D c
Externí odkaz:
https://doaj.org/article/fe04cb70067b4e8287a8e0e8e4148976
Autor:
Daisuke Mori, Shigeru Miyagawa, Takuji Kawamura, Daisuke Yoshioka, Hiroki Hata, Takayoshi Ueno, Koichi Toda, Toru Kuratani, Miwa Oota, Kotoe Kawai, Hayato Kurata, Hiroyuki Nishida, Akima Harada, Toshihiko Toyofuku, Yoshiki Sawa
Publikováno v:
Cell Transplantation, Vol 32 (2023)
Although mesenchymal stem cell transplantation has been successful in the treatment of ischemic cardiomyopathy, the underlying mechanisms remain unclear. Herein, we investigated whether mitochondrial transfer could explain the success of cell therapy
Externí odkaz:
https://doaj.org/article/e9c453be252f468fb4982976085482c5
Autor:
Takaaki Samura, Shigeru Miyagawa, Takuji Kawamura, Satsuki Fukushima, Jun‐ya Yokoyama, Maki Takeda, Akima Harada, Fumiya Ohashi, Ryoko Sato‐Nishiuchi, Toshihiko Toyofuku, Koichi Toda, Kiyotoshi Sekiguchi, Yoshiki Sawa
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 16 (2020)
Background Extracellular matrix, especially laminin‐221, may play crucial roles in viability and survival of human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPS‐CMs) after in vivo transplant. Then, we hypothesized laminin‐221 m
Externí odkaz:
https://doaj.org/article/b8fff519c03c446a8de521afa67c093a
Autor:
Masako Ogawa, Tomonari Matsuda, Atsushi Ogata, Toshimitsu Hamasaki, Atsushi Kumanogoh, Toshihiko Toyofuku, Toshio Tanaka
Publikováno v:
Autoimmune Diseases, Vol 2013 (2013)
Objective. To evaluate what types of DNA damages are detected in rheumatoid arthritis (RA). Methods. The DNA adducts such as 8-oxo-hydroxy-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), 1,N6-etheno-2′-deoxyadenosine (εdA), and heptanone-etheno-2′-d
Externí odkaz:
https://doaj.org/article/69ba07618ae645c4910d8df3af4e18fe
Publikováno v:
The Journal of Immunology. 204:1373-1385
Adoptive cellular therapy and its derivative, chimeric AgR T cell therapy, have achieved significant progress against cancer. Major barriers persist, however, including insufficient induction of cytotoxic T cells and exhaustion of tumor-infiltrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d0868c3fad41f95c128d19bbb16125
https://doi.org/10.4049/jimmunol.1900937
https://doi.org/10.4049/jimmunol.1900937
Autor:
Koichi Toda, Kotoe Kawai, Takayoshi Ueno, Toshihiko Toyofuku, Yoshiki Sawa, Hiroyuki Nishida, Daisuke Mori, Miwa Oota, Daisuke Yoshioka, Toru Kuratani, Takuji Kawamura, Shigeru Miyagawa, Hiroki Hata, Akima Harada, Hayato Kurata
Although mesenchymal stem cell transplantation has been efficacious in the treatment of ischemic cardiomyopathy, the underlying mechanisms remain unclear. Herein, we investigated whether mitochondrial transfer could explain the success of cell therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43434563c66d6d36b690f36da2c8da1
https://doi.org/10.21203/rs.3.rs-107042/v1
https://doi.org/10.21203/rs.3.rs-107042/v1
Autor:
Yoshiki Sawa, Satsuki Fukushima, Maki Takeda, Akima Harada, Ryoko Sato-Nishiuchi, Koichi Toda, Toshihiko Toyofuku, Shigeru Miyagawa, Takuji Kawamura, Fumiya Ohashi, Kiyotoshi Sekiguchi, Takaaki Samura, Junya Yokoyama
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Extracellular matrix, especially laminin‐221, may play crucial roles in viability and survival of human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPS‐CMs) after in vivo transplant. Then, we hypothesized laminin‐221 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d88fe607d66cd95639dbdf0a0c6a9a8
https://doi.org/10.1161/jaha.119.015841
https://doi.org/10.1161/jaha.119.015841
Autor:
Takuji Kawamura, Shohei Yoshida, Fumiya Ohashi, Koichi Toda, Toshihiko Toyofuku, Noriyuki Kashiyama, Satsuki Fukushima, Yoshiki Sawa, Shigeru Miyagawa
Publikováno v:
Molecular Therapy
In this study, we proposed that the functionality or phenotype of differentiated cardiomyocytes derived from human induced pluripotent stem cells (iPSC-CMs) might be modified by co-culture with mesenchymal stem cells (MSCs), resulting in an improved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b522ecd132427b0ef69460c72dd8ec
http://europepmc.org/articles/PMC6224789
http://europepmc.org/articles/PMC6224789
Autor:
Yoshitomo Hayama, Satoshi Nojima, Hyota Takamatsu, Daisuke Okuzaki, Junichi Takagi, Tetsuya Kimura, Shohei Koyama, Masayuki Nishide, Yasuhiro Kato, Tomomi Shimogori, Takeshi Nakatani, Atsushi Kumanogoh, Sujin Kang, Yuhei Kinehara, Yoshiyuki Kioi, Yoshimitsu Nakanishi, Toshihiko Toyofuku
Publikováno v:
Nature Immunology. 19:561-570
Polarization of macrophages into pro-inflammatory or anti-inflammatory states has distinct metabolic requirements, with mechanistic target of rapamycin (mTOR) kinase signaling playing a critical role. However, it remains unclear how mTOR regulates me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ce8f83187daf36d140ae7863f00882
https://doi.org/10.1038/s41590-018-0108-0
https://doi.org/10.1038/s41590-018-0108-0
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 204(5)
Adoptive cellular therapy and its derivative, chimeric AgR T cell therapy, have achieved significant progress against cancer. Major barriers persist, however, including insufficient induction of cytotoxic T cells and exhaustion of tumor-infiltrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fc826a68cdf87c0a100f0151741edc2
https://pubmed.ncbi.nlm.nih.gov/31969386
https://pubmed.ncbi.nlm.nih.gov/31969386