Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Toshihiko Toida"'
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Chondroitin sulfate (CS) and its isomeric variant, dermatan sulfate (DS), are complex glycosaminoglycans (GAGs) which are ubiquitous components of the extracellular matrix in various tissues including the brain. CS and/or DS are known to bind to a va
Externí odkaz:
https://doaj.org/article/ca2478fedd7e4981ac6fecce7e385c7f
Autor:
Daichi Ito, Dan Ge, Noriyuki Kogure, Hitomi Manaka, Yusuke Terui, Hiromitsu Takayama, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi
Publikováno v:
Heliyon, Vol 6, Iss 10, Pp e05168- (2020)
Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in the generation of a poly-ion
Externí odkaz:
https://doaj.org/article/812c12e1abe74ff3970ea6d46b5bbe0b
Autor:
Kazuhiro Nishimura, Moemi Okamoto, Rina Shibue, Toshio Mizuta, Toru Shibayama, Tetsuhiko Yoshino, Teruki Murakami, Masashi Yamaguchi, Satoshi Tanaka, Toshihiko Toida, Kazuei Igarashi
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229744 (2020)
Mast cells have secretory granules containing chemical mediators such as histamine and play important roles in the immune system. Polyamines are essential factors for cellular processes such as gene expression and translation. It has been reported th
Externí odkaz:
https://doaj.org/article/4932559cb45d4fe9bae74bebf8170c02
Autor:
Kyohei Higashi, Toshihiko Toida
Publikováno v:
Bio-Protocol, Vol 7, Iss 21 (2017)
Chondroitin sulfate (CS), a member of the glycosaminoglycan (GAG) family of carbohydrates, is composed of linear, sulfated repeating disaccharide sequences of N-acetyl-D-galactosamine (GalNAc) and glucuronic acid (GlcA). Recently, a keratan sulfate (
Externí odkaz:
https://doaj.org/article/f0e6587ba402416d85e468df20162e48
Autor:
Kyohei Higashi, Toshihiko Toida
Publikováno v:
Bio-Protocol, Vol 7, Iss 15 (2017)
Glycosaminoglycans (GAGs) including chondroitin sulfate (CS), dermatan sulfate (DS), heparin (HP), heparan sulfate (HS) and keratan sulfate (KS) are linear, sulfated repeating disaccharide sequences containing hexosamine and uronic acid (or galactose
Externí odkaz:
https://doaj.org/article/c36fc13b97104032b5be0fac6472ea6a
Autor:
Kyohei Higashi, Yoshiki Takeuchi, Ann Mukuno, Hideyuki Tomitori, Masaki Miya, Robert J Linhardt, Toshihiko Toida
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120860 (2015)
Shark fin, used as a food, is a rich source of glycosaminoglyans (GAGs), acidic polysaccharides having important biological activities, suggesting their nutraceutical and pharmaceutical application. A comprehensive survey of GAGs derived from the fin
Externí odkaz:
https://doaj.org/article/728f202e1bb04c76a0ccaccb2b0649f2
Autor:
Papawee Suabjakyong, Ryotaro Saiki, Leo J L D Van Griensven, Kyohei Higashi, Kazuhiro Nishimura, Kazuei Igarashi, Toshihiko Toida
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122733 (2015)
The basidiomycetous mushroom Phellinus igniarius (L.) Quel. has been used as traditional medicine in various Asian countries for many years. Although many reports exist on its anti-oxidative and anti-inflammatory activities and therapeutic effects ag
Externí odkaz:
https://doaj.org/article/f5ffb257c8644725b533a969a6b6a3fb
Autor:
Kyohei Higashi, Masataka Imamura, Satoshi Fudo, Takeshi Uemura, Ryotaro Saiki, Tyuji Hoshino, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102234 (2014)
Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2. The Km values for putrescine and spermidine were 7.50 and 6.76 mM,
Externí odkaz:
https://doaj.org/article/167099fd587e430ab52a376e61992d78
Autor:
Keiko Tadano-Aritomi, Toshiyuki Hikita, Atsushi Suzuki, Hidenao Toyoda, Toshihiko Toida, Toshio Imanari, Ineo Ishizuka
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 10, Pp 1604-1608 (2001)
A variety of procedures have been developed for determining the sulfate ester content of various biomolecules. Ion chromatography (IC), that is, quantitation of ionic substances by ion conductimetry after separation by anion-exchange chromatography,
Externí odkaz:
https://doaj.org/article/d2db0a6174d54a1b894b3b1a9fae1290
Autor:
Kento Shionoya, Takehiro Suzuki, Mako Takada, Kazuki Sato, Shoichi Onishi, Naoshi Dohmae, Koichiro Nishino, Takeshi Wada, Robert J. Linhardt, Toshihiko Toida, Kyohei Higashi
Publikováno v:
International Journal of Biological Macromolecules. 208:333-342
Cartilage in the head of sturgeon or salmon has been gaining attention as a rich source of functional chondroitin sulfate (CS) or proteoglycans. Although the cartilage was found in the heads of other bony fishes, the structure of CS and its core prot