Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Toshihiko Shirafuji"'
Autor:
Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002006 (2024)
Proteome analyses of the postsynaptic density (PSD), a proteinaceous specialization beneath the postsynaptic membrane of excitatory synapses, have identified several thousands of proteins. While proteins with predictable functions have been well stud
Externí odkaz:
https://doaj.org/article/eb1ee277ee014075a0fa347c43877bf9
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147466 (2016)
G-protein-coupled receptor (GPR) 3 is a member of the GPR family that constitutively activates adenylate cyclase. We have reported that the expression of GPR3 in cerebellar granular neurons (CGNs) contributes to neurite outgrowth and modulates neuron
Externí odkaz:
https://doaj.org/article/a4792f16da7e4622a47d3563ec8d4b88
Autor:
Takehiko Ueyama, Haruo Shimazaki, Norio Sakai, Naoko Adachi, Naoaki Saito, Tatsuhiro Miyagi, Shigeru Tanaka, Toshihiko Shirafuji, Izumi Hide
Publikováno v:
Molecular and Cellular Neuroscience. 98:46-53
Spinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia with myoclonus, dystonia, spasticity, and rigidity. Although missense mutations and a deletion mutation have been found in t
Autor:
Mayumi Kamigaki, Shigeru Tanaka, Kana Harada, Hiroko Shiraki, Michihiro Hide, Takahiro Seki, Norio Sakai, Yuhki Yanase, Toshihiko Shirafuji, Yoshiki Tanaka, Izumi Hide
Publikováno v:
Neurochemistry International. 93:82-94
Toll-like receptor (TLR) 4 mediates inflammation and is also known to trigger apoptosis in microglia. Our time-lapse observations showed that lipopolysaccharide (LPS) stimulation induced rapid death in primary cultures of rat microglia, while a porti
Autor:
Seiya Murakawa, Toshihiko Shirafuji, Norio Sakai, Kazusa Katarao, Naoto Usuki, Shigeru Tanaka, Hikaru Yamamoto, Masaya Asano, Izumi Hide
Publikováno v:
Acta Histochemica et Cytochemica
The function of the serotonin transporter (SERT) is regulated by its membrane trafficking. Previously, we showed that the C-terminus-deleted mutant of SERT (SERTΔCT) exhibited an aberrant membrane trafficking and subsequent retention at the endoplas
Autor:
Yusuke Sotomaru, Ken-ichi Yoshino, Toshihiko Shirafuji, Izumi Hide, Takehiko Ueyama, Taro Ueda, Norio Sakai, Junsuke Uwada, Naoaki Saito, Azumi Kaneoka, Shigeru Tanaka, Naoko Adachi
Protein kinase Cγ (PKCγ) knock-out (KO) animals exhibit symptoms of Parkinson's disease (PD), including dopaminergic neuronal loss in the substantia nigra. However, the PKCγ substrates responsible for the survival of dopaminergic neuronsin vivohav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a7af147fcf508f289343b74c2748f6
https://europepmc.org/articles/PMC6596106/
https://europepmc.org/articles/PMC6596106/
Publikováno v:
Acta Histochemica et Cytochemica
There are many commercial antibodies with little information provided by their suppliers as to their reliability. Accordingly, commercial antibodies require proper validation before being used in scientific research. In this study, we validated sever
Autor:
Naoko Adachi, Norio Sakai, Takehiko Ueyama, Ken-ichi Yoshino, Toshihiko Shirafuji, Toshio Matsuda, Hideyuki Takahashi, Tatsushi Toda, Tetsuaki Nashida, Yukio Ago, Ken Koda, Naoki Hiramatsu, Naoaki Saito
Publikováno v:
Journal of Neuroscience. 34(28):9268-9280
Protein kinase C (PKC) has been implicated in the control of neurotransmitter release. The AS/AGU rat, which has a nonsense mutation in PKCγ, shows symptoms of parkinsonian syndrome, including dopamine release impairments in the striatum. Here, we f
Autor:
Takeshi Hamada, Takeshi Kobayashi, Toshihiko Shirafuji, Naoaki Saito, Takehiko Ueyama, Hirofumi Sakaguchi, Takashi Nakamura, Jeonghyun Son
Publikováno v:
The Journal of Immunology. 191:2560-2569
In its resting state, Rho GDP-dissociation inhibitor (RhoGDI) α forms a soluble cytoplasmic heterodimer with the GDP-bound form of Rac. Upon stimulation, the dissociation of RhoGDIα from the RhoGDIα–Rac complex is a mandatory step for Rac activa
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147466 (2016)
PLoS ONE
PLoS ONE
G-protein-coupled receptor (GPR) 3 is a member of the GPR family that constitutively activates adenylate cyclase. We have reported that the expression of GPR3 in cerebellar granular neurons (CGNs) contributes to neurite outgrowth and modulates neuron