Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Toshihiko Murayama"'
Autor:
Ai Tanaka, Takuya Honda, Masataka Yasue, Risa Yamazaki, Hiroto Hatakeyama, Akihiro Hisaka, Masato Mashimo, Takafumi Kohama, Hiroyuki Nakamura, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 150, Iss 1, Pp 1-8 (2022)
Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to ceramide-1-phosphate (C1P) by ceramide kinase (CerK). The CerK/C1P pathway regulates many cellular functions, but its roles in immune/inflammation-related (IIR) diseases in
Externí odkaz:
https://doaj.org/article/2db332f1b98a42a0af385d7a08a18700
Autor:
Hiroyuki Nakamura, Yuan Zhou, Yuka Sakamoto, Ayako Yamazaki, Eon Kurumiya, Risa Yamazaki, Kyota Hayashi, Yoshitoshi Kasuya, Kazuaki Watanabe, Junya Kasahara, Mamoru Takabatake, Koichiro Tatsumi, Ichiro Yoshino, Takuya Honda, Toshihiko Murayama
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114405- (2023)
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease. The disease involves excessive accumulation of fibroblasts and myofibroblasts, and myofibroblasts differentiated by pro-fibrotic factors promote the deposition of extracellula
Externí odkaz:
https://doaj.org/article/73aa015a64624010884b8435cb1bab01
Autor:
Zhaotong Wang, Takamasa Mizoguchi, Takahito Kuribara, Masaya Nakajima, Mayuu Iwata, Yuka Sakamoto, Hiroyuki Nakamura, Toshihiko Murayama, Tetsuhiro Nemoto, Motoyuki Itoh
Publikováno v:
Open Biology, Vol 11, Iss 2 (2021)
Polypyrrole-based polyamides are used as sequence-specific DNA probes. However, their cellular uptake and distribution are affected by several factors and have not been extensively studied in vivo. Here, we generated a series of fluorescence-conjugat
Externí odkaz:
https://doaj.org/article/bfb9c22df5f24ab5967660ee2058d2d7
Autor:
Keita Ugai, Shuichi Matsuda, Hideki Mikami, Ayako Shimada, Tomoko Misawa, Hiroyuki Nakamura, Koichiro Tatsumi, Masahiko Hatano, Toshihiko Murayama, Yoshitoshi Kasuya
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiopathogenesis. The activation of extracellular matrix (ECM)-producing myofibroblasts plays a key role in fibrotic tissue remodeling. The dedifferentiation of myofibroblasts has
Externí odkaz:
https://doaj.org/article/9b0bd11361a84af1bb5861e8bcc1783b
Autor:
Hiroyuki Nakamura, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 3, Pp 307-312 (2014)
The arachidonic acid (AA) cascade is regulated mainly by the actions of two rate-limiting enzymes, phospholipase A2 (PLA2) and inducible cyclooxygenase-2 (COX-2). PLA2 acts to generate AA, which serves as the precursor substrate for COX-2 in the meta
Externí odkaz:
https://doaj.org/article/1c9a5f075e4c46e4b01cb33b1eb21b35
Autor:
Koichi Kawada, Masayuki Kaneko, Yasuyuki Nomura, Seisuke Mimori, Hiroshi Hamana, Kiyokazu Ogita, Toshihiko Murayama, Hiromichi Fujino, Yasunobu Okuma
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 3, Pp 208-212 (2011)
Abstract.: Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and b
Externí odkaz:
https://doaj.org/article/82c73a801eed449eaac1fcf9398fb8b7
Autor:
Hiroyuki Nakamura, Shigeo Wakita, Akiko Suganami, Yutaka Tamura, Kentaro Hanada, Toshihiko Murayama
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 720-728 (2010)
We examined the effect of the cellular sphingolipid level on the release of arachidonic acid (AA) and activity of cytosolic phospholipase A2α (cPLA2α) using two Chinese hamster ovary (CHO)-K1-derived mutants deficient in sphingolipid synthesis: LY-
Externí odkaz:
https://doaj.org/article/0fd9fa2172ea421285aba532c0d1f4b5
Autor:
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 114, Iss 4, Pp 420-432 (2010)
Abstract.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromato
Externí odkaz:
https://doaj.org/article/1750bccab989434593a4ff4bd6cc1f3e
Autor:
Masaya Shimizu, Yuki Muramatsu, Eiko Tada, Takeshi Kurosawa, Erika Yamaura, Hiroyuki Nakamura, Hiromichi Fujino, Yuuya Houjyo, Yuri Miyasaka, Yuuki Koide, Atsushi Nishida, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 3, Pp 431-443 (2009)
Sphingolipid metabolites including ceramide, sphingosine, and their phosphorylated products [sphingosine-1-phosphate (S1P) and ceramide-1-phosphate] regulate cell functions including arachidonic acid (AA) metabolism and cell death. The development of
Externí odkaz:
https://doaj.org/article/3e722a85953147f2994da861c2062214
Autor:
Ikuo Murakami, Yuri Hamada, Satoshi Yamane, Hiromichi Fujino, Shunji Horie, Toshihiko Murayama
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 1, Pp 128-138 (2009)
Nicotine has been shown to reduce both tone and muscular activity in the human colon by releasing nitric oxide (NO) from nerves. To our knowledge, however, the effect of nicotine on mouse colon has not been elucidated, and the response in tissue from
Externí odkaz:
https://doaj.org/article/429bb67d198e4bba847004f3b1e08120