Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Toshihiko Maruyama"'
Publikováno v:
eLife, Vol 3 (2014)
Apoptosis is coupled with recruitment of macrophages for engulfment of dead cells, and with compensatory proliferation of neighboring cells. Yet, this death process is silent, and it does not cause inflammation. The molecular mechanisms underlying an
Externí odkaz:
https://doaj.org/article/d3a48e7cf1084ea0a64c41b61ca76108
Autor:
Hideki Hayasaka, Akihiro Hoshino, Nozomu Sonoyama, Satoshi Naito, Toshihiko Maruyama, Hiroyuki Matsumoto, Chuichi Mizoguchi
Publikováno v:
Journal of the Japan Institute of Energy. 97:370-378
Publikováno v:
Gene. 505:46-52
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS)-produced PGD2 accelerates adipogenesis. In this study, we investigated the molecular mechanism of PGD2-mediated activation of adipogenesis in mouse adipocytic 3T3-L1 cells. LC/MS analysis showed t
Publikováno v:
Biochemical and Biophysical Research Communications. 415:539-544
Amyotrophic lateral sclerosis (ALS) is a late-onset, progressive motor neuronal degenerative disease occurring as sporadically and as a familial disorder. The patients with ALS typically become progressively paralyzed and develop respiratory failure
Autor:
Kosuke Aritake, Daisuke Irikura, Shigeru Shimamoto, Nanae Nagata, Toshihiko Maruyama, Yoshihiro Urade
Publikováno v:
The Journal of Biological Chemistry
We report here that 4-dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine (AT-56) is an orally active and selective inhibitor of lipocalin-type prostaglandin (PG) D synthase (L-PGDS). AT-56 inhibited human and mouse L-PGDSs in
Autor:
Nanae Nagata, Antoine Martinez, Toshihiko Maruyama, Zakayi Kabututu, Michèle Manin, Yoshihiro Urade, Sarah Lambert, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud
Publikováno v:
Journal of Biochemistry. 145:161-168
Here, we show that three enzymes belonging to the 1B group of the aldo-keto reductase (AKR) superfamily, i.e., human placental aldose reductase (AKR1B1), mouse kidney aldose reductase (AKR1B3) and mouse vas deferens protein (AKR1B7), catalyse the red
Autor:
Kouji Watanabe, Takashi Sugimura, Yukihiko Sugimoto, Manabu Negishi, Toshihiko Maruyama, Toshihiko Kawamori, Mami Takahashi, Shuh Narumiya, Yutaka Shoji, Tomohiro Kitamura, Keiji Wakabayashi
Publikováno v:
Gut. 53:1151-1158
Involvement of prostaglandin E(2) (PGE(2)) receptors EP(1), EP(2), and EP(4) in the formation of aberrant crypt foci (ACF) and/or intestinal polyps has been suggested. In contrast, EP(3) appears to have no influence on the early stages of colon carci
Autor:
Moriyoshi Shitara, Toshihiko Maruyama, Taku Tamamori, Manabu Iguchi, Hidehiro Shitara, Keiji Takano
Publikováno v:
MATERIALS TRANSACTIONS. 44:2456-2460
A novel agitation method using ozone was applied to removing BOD5, CODMn, color, and NH4-N in organic waste water filled in a cylindrical vessel. The organic waste water was agitated by injecting the same organic waste water into the bath through a c
Autor:
Shunichi Fukuzumi, Bruno Kilunga Kubata, Toshihiko Maruyama, Samuel K. Martin, Michael Duszenko, Kei Ohkubo, Zakayi Kabututu, Tomoyoshi Nozaki, Michael Lazarus, Yoshihiro Urade, Craig Joe Munday
Publikováno v:
The Journal of Experimental Medicine
Trypanosoma cruzi is the etiological agent of Chagas' disease. So far, first choice anti-chagasic drugs in use have been shown to have undesirable side effects in addition to the emergence of parasite resistance and the lack of prospect for vaccine a