Výsledky vyhledávání - "Toshihiko Kohji"

Anti-epileptics alter hypothyroidism of patients with severe motor and intellectual disabilities

Autor: Tsunenori, Hirayama, Harumi, Saijo, Toshihiko, Kohji, Takanori, Ezoe, Sui, Sone, Katsuhito, Araki, Hiroshi, Hamaguchi, Hisaharu, Suzuki, Kiyoko, KKurata

Publikováno v: No to hattatsu = Brain and development. 49(1)

Objective: Anti-epileptic drugs, such as carbamazepine (CBZ) or phenytoin, may induce hypothyroidism in epilepsy patients. We assessed thyroid function of chronic patients with severe motor and intellectual disabilities (SMID) in our hospital. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ed6b082fc860f7a7a04b1016cff6b42
https://pubmed.ncbi.nlm.nih.gov/30011149

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MLC1 mutations in Japanese patients with megalencephalic leukoencephalopathy with subcortical cysts

Autor: Tadashi Matsubasa, Akira Oka, Shino Shimada, Yoshiaki Nakayama, Hiroko Tsukamoto, Keiko Shimojima, Toshiyuki Yamamoto, Toshihiko Kohji, Teruaki Masuda

Publikováno v: Human Genome Variation

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is an autosomal recessive neurological disorder manifesting early onset macrocephaly and delayed-onset neurological deterioration. Characteristic radiological findings revealed by brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b168037c671f2b13ee4fd8a778b6a0
https://doi.org/10.1038/hgv.2014.19

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Immunohistochemical analysis of brainstem lesions in infantile spasms

Autor: Jun Kohyama, Masahiro Itoh, Yoshihide Iwakawa, Toshihiko Kohji, Satoko Kumada, Masaharu Hayashi, Satoshi Araki, Yoshio Morimatsu, Jun-ichi Satoh, Naoyuki Tanuma

Publikováno v: Neuropathology. 20:297-303

Whether the cerebral or subcortical lesions are involved in the pathogenesis in infantile spasms (IS) remains to be determined. To investigate the functional lesions of the subcortical structures in IS, the brainstem expression of neurotransmitters,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a0d103e0657c942242d85a7c04a0ab
https://doi.org/10.1111/j.1440-1789.2000.00353.x

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Coexpression of Fas/FasL and Bax on brain and infiltrating T cells in the central nervous system is closely associated with apoptotic cell death during autoimmune encephalomyelitis

Autor: Yoh Matsumoto, Toshihiko Kohji

Publikováno v: Journal of Neuroimmunology. 106:165-171

Recent studies have suggested that autoimmune inflammation elicited in the central nervous system (CNS) is subsided by apoptotic cell death of inflammatory cells. To elucidate the molecular mechanism of apoptosis of infiltrating T and other cells occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc509ae9d4364cf1e6ba14839ca93748
https://doi.org/10.1016/s0165-5728(00)00238-1

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Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis

Autor: Toshihiko Kohji, Takashi Kojima, Yukihiko Aikawa, Taekyun Shin, Naoyuki Tanuma, Yoshihiro Ishihara, Yoh Matsumoto

Publikováno v: Journal of Neuroimmunology. 73:197-206

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the central nervous system that can be induced by immunization with myelin basic protein (MBP)/complete Freund's adjuvant and serves as a model for multiple sclerosis. Rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eafbe728640fe2a352e2a01467c02d
https://doi.org/10.1016/s0165-5728(96)00199-3

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Impairment of respiratory rhythmogenesis and sequelae of bacterial meningitis

Autor: Masayuki Shimohira, Takeshi Hasegawa, Jun Kohyama, Yoshihide Iwakawa, Toshihiko Kohji

Publikováno v: Pediatric Neurology. 12:357-360

A 9-year-old boy with respiratory disturbance associated with medullary lesions after pneumococcal meningitis is reported. Although he lives a normal daily life, he cannot cough or sneeze. A polysomnographic study revealed a low respiration rate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e9279910d04c8eaa7838a9d9546936
https://doi.org/10.1016/0887-8994(95)00051-g

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Cerebellar neurodegeneration in human hereditary DNA repair disorders

Autor: Toshihiko Kohji, Kimiko Tamagawa, Masao Minagawa, Kei Shioda, Masaya Oda, Yoshio Morimatsu, Masaharu Hayashi

Publikováno v: Neuroscience letters. 243(1-3)

Recent findings have focused attention on the role of apoptosis in neurodegenerative diseases, however, the apoptotic process in child-onset brain disorders has been little investigated. Xeroderma pigmentosum (XP) and Cockayne syndrome (CS) are hered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9d1f917c6e9744901a7ad04df88988
https://pubmed.ncbi.nlm.nih.gov/9535131

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Phasic loss of intercostal muscle activity occurring with rapid eye movements during REM sleep

Autor: Jun Kohyama, Masayuki Shimohira, Toshihiko Kohji, Yoshihide Iwakawa

Publikováno v: Neuroscience letters. 164(1-2)

We tried to estimate the phasic motor inhibition occurring with rapid eye movements (REMs) during REM sleep in children by means of polysomnography. Phasic inhibition of intercostal muscle activity with REMs has been proved by averaging the integrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a159838e1b436d39e6217a4a34a4ff15
https://pubmed.ncbi.nlm.nih.gov/8152609

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