Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Toshihiko Ikeuchi"'
Autor:
Daichi Fujiki, Toshihiko Ikeuchi, Hiroki Maruoka, Koji Shimoke, Hiromichi Kawa, Ryosuke Yamazoe, Takuma Tomioka
Publikováno v:
Neuroscience Research. 88:39-48
Histone deacetylase (HDAC) inhibitors induce histone acetylation and gene expression by changing local chromatin structures. They can thereby influence various cells to proliferate or differentiate. It has been reported that trichostatin A (TSA) or v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23dc942c289c09d792620ce05a61e61
https://doi.org/10.1016/j.neures.2014.07.009
https://doi.org/10.1016/j.neures.2014.07.009
Autor:
Toshihiko Ikeuchi, Kazuya Yasuzumi, Harue Sasaya, Ayumi Fujita, Koji Shimoke, Hiroki Maruoka, Taiki Waki, Yuichi Kato
Publikováno v:
Advances in Biological Chemistry. :92-105
Endocrine-disrupting chemicals (EDCs) are known to exert estrogen-like effects that are similar to those made by naturally produced hormones or by inhibition of the receptors in the cell receiving the hormones. Recently, several reports have indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d9a355af5d8316351d79b52b54f1dbe
https://doi.org/10.4236/abc.2012.22012
https://doi.org/10.4236/abc.2012.22012
Autor:
Harue Sasaya, Yuichi Shimamura, Hiroki Maruoka, Yosuke Nakatani, Koji Shimoke, Toshihiko Ikeuchi
Publikováno v:
Journal of Biochemistry. 148:93-101
An elevated level of cyclic AMP (cAMP) within cells activates gene expression through the cAMP-PKA-CREB pathway. Among the CREB target genes, some immediate early genes exist that are responsive to cAMP including the nur77 and c-fos genes. Treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0730bec69aa4563a49b0160aad3f191a
https://doi.org/10.1093/jb/mvq036
https://doi.org/10.1093/jb/mvq036
Autor:
Ko-ichi Oshiman, Miho Sasaki-Mori, Kenji Fukunaga, Yoshinobu Matsumura, Ayako Akahira, Chiemi Hosokawa, Tetsuaki Tsuchido, Toshihiko Ikeuchi
Publikováno v:
Biocontrol Science. 14:161-169
One hundred and seven soil samples were collected from various places in Japan, and their bisphenol-A (BPA, 2,2-bis(4-Hydroxyphenyl) propane) degradative capacities were evaluated. Eighty-five soil samples possessed BPA degradative capacities, and 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b68dc6cc04e19bcc8750adf83b633d
https://doi.org/10.4265/bio.14.161
https://doi.org/10.4265/bio.14.161
Publikováno v:
Journal of Neurochemistry. 79:489-498
We have investigated mechanisms of nicotine-induced phosphorylation of extracellular signal-regulated protein kinase (p42/44 MAP kinase, ERK) and cAMP response element binding protein (CREB) in PC12h cells. Nicotine transiently induced ERK phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059e79fc28ce6b234d220eecb8b2dba0
https://doi.org/10.1046/j.1471-4159.2001.00602.x
https://doi.org/10.1046/j.1471-4159.2001.00602.x
Autor:
Takahiro Utsumi, Toshihiko Ikeuchi, Koji Shimoke, Kenji Fukunaga, Hitoshi Nakayama, Yoshinobu Matsumura, Harue Sasaya
Publikováno v:
Journal of Biochemistry. 144:251-257
We previously reported that nicotine protected against tunicamycin (Tm)-induced ER stress-mediated apoptosis, but not thapsigargin (Tg)-induced apoptosis in PC12 cells. In the present study, we report that the expression of glucose-regulated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c501b87015ac023d742b40c5ad93d
https://doi.org/10.1093/jb/mvn063
https://doi.org/10.1093/jb/mvn063
Autor:
Yasuo Nagaoka, Yuki Kawai, Shinichi Uesato, Koji Shimoke, Hiroshi Kuwajima, D. Nakashima, Tadao Oikawa, Taishi Maeda, Toshihiko Ikeuchi
Publikováno v:
European Journal of Medicinal Chemistry. 41:697-708
New series histone deacetylase inhibitors comprising a hydroxamic acid or 2-aminobenzamide group as a zinc-chelating function were synthesized and evaluated for antiproliferative activities against a panel of human cancer cells. The 2-aminobenzamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733b5f27271a4a04758957e34fc6b7f0
https://doi.org/10.1016/j.ejmech.2006.02.002
https://doi.org/10.1016/j.ejmech.2006.02.002
Autor:
Masashi Yamada, Satomi Takai, Koji Shimoke, Hisatsugu Koshimizu, Hidenori Ichijo, Kohsuke Takeda, Satoru Yamagishi, Hiroshi Hatanaka, Toshihiko Ikeuchi
Publikováno v:
Journal of Biochemistry. 133:719-724
Previously, we reported that p38, which belongs to the mitogen-activated protein kinase (MAPK) superfamily, has an important role in the induction of apoptosis of cultured cerebellar granule neurons. However, the molecular mechanisms upstream of p38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982a91bc2b6264b6e794e01344254841
https://doi.org/10.1093/jb/mvg092
https://doi.org/10.1093/jb/mvg092
Publikováno v:
Life Sciences. 73:581-593
Glucose-regulated protein 78 (GRP78)/Immunoglobulin binding protein (Bip) is a chaperone which functions to protect cells from endoplasmic reticulum (ER) stress. GRP78/Bip is expressed following ER stress induced by thapsigargin, tunicamycin or chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbd07921b2b242f95bbfb6a0c2dc8f5
https://doi.org/10.1016/s0024-3205(03)00351-5
https://doi.org/10.1016/s0024-3205(03)00351-5
Publikováno v:
Journal of Neurochemistry. 83:1372-1379
Nicotine treatment triggers calcium influx into neuronal cells, which promotes cell survival in a number of neuronal cells. Phosphoinositide (PI) 3-kinase and downstream PI3-kinase target Akt have been reported to be important in the calcium-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::835a52a6b8040080bce1fb293e9b8051
https://doi.org/10.1046/j.1471-4159.2002.01248.x
https://doi.org/10.1046/j.1471-4159.2002.01248.x