Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Toshihiko Hirano"'
Autor:
Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Jinwen Min, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Cepharanthin® alone or in combination with glucocorticoid (GC) has been used to treat chronic immune thrombocytopenia (ITP) since the 1990s. Cepharanthine (CEP) is one of the main active components of Cepharanthin®. The purpose
Externí odkaz:
https://doaj.org/article/714da0c0f0b54aeda986ca505bb97532
Autor:
Bowen Yu, Bo Yuan, JingZhe Li, Anna Kiyomi, Hidetomo Kikuchi, Hideki Hayashi, Xiaomei Hu, Mari Okazaki, Munetoshi Sugiura, Toshihiko Hirano, Yingyi Fan, Xiaohua Pei, Norio Takagi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Novel therapeutic strategies for breast cancer are urgently needed due to the sustained development of drug resistance and tumor recurrence. Trivalent arsenic derivative (arsenite, AsIII) has been reported to induce cytotoxicity in breast cancer cell
Externí odkaz:
https://doaj.org/article/8374216646314df88667b782892aa7fd
Autor:
Bo Yuan, Mingjiang Yao, Xiao Wang, Ai Sato, Ayane Okazaki, Hana Komuro, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei, Xiaomei Hu, Toshihiko Hirano, Norio Takagi
Publikováno v:
Cancer Cell International, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat due to its aggressive, metastatic behavior, and a lack of a targeted therapy. Trivalent arsenic derivatives (arsenite, AsIII) wit
Externí odkaz:
https://doaj.org/article/1bc219f727e241ff8f19c7022c702e30
Autor:
Anna Kiyomi, Masujiro Makita, Tomoko Ozeki, Na Li, Aiko Satomura, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Takuji Iwase, Toshihiko Hirano
Publikováno v:
Translational Oncology, Vol 8, Iss 4, Pp 318-326 (2015)
OBJECTIVES: Several cytokines secreted from breast cancer tissues are suggested to be related to disease prognosis. We examined Th1/Th2/Th17 cytokines produced from three-dimensionally cultured breast cancer tissues and related them with patient clin
Externí odkaz:
https://doaj.org/article/fd66c36d6bf44a29a08bf10d592715cb
Autor:
Kentaro Sugiyama Ph.D., Kazuya Isogai, Satoshi Horisawa, Akira Toyama, Hiroshi Satoh, Kazuhide Saito, Yuki Nakagawa, Masayuki Tasaki, Kota Takahashi, Toshihiko Hirano
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Basiliximab is a recently developed immunosuppressive agent for the prevention of acute allograft rejection in renal transplant recipients. The combination use of basiliximab and a calcineurin inhibitor was suggested to be more effective in compariso
Externí odkaz:
https://doaj.org/article/21dafdf17c7e409bb009ffdf634ae830
Autor:
Yu Kihara, Naoto Matsuno, Abuduxukuer Mijiti, Takeshi Nagao, Hironori Takeuchi, Sakae Unezaki, Toshihiko Hirano Ph.D.
Publikováno v:
Cell Transplantation, Vol 18 (2009)
The in vitro response of peripheral blood mononuclear cells (PBMCs) to the suppressive effects of calcineurin inhibitors is known to correlate with the clinical efficacy of drugs used in renal transplantations. The present study was conducted to exam
Externí odkaz:
https://doaj.org/article/aadbc66eb54c4dd5a6075b915bfaaf51
Autor:
Abuduxukuer Mijiti, Naoto Matsuno, Hironori Takeuchi, Sakae Unezaki, Takeshi Nagao, Toshihiko Hirano
Publikováno v:
Cell Transplantation, Vol 18 (2009)
Successful immunosuppressive therapy is critical for liver transplantation; however, a considerable number of patients experience fatal rejection or alternatively exhibit serious infection resulting from excessive immunosuppression. The in vitro tacr
Externí odkaz:
https://doaj.org/article/303402ecf20f4baaa6c1e62749dad8fb
Autor:
Abuduxhukuer Mijiti, Naoto Matsuno, Tohru Iwahori, Hironori Takeuchi, Takeshi Nagao, Kitaro Oka, Toshihiko Hirano Ph.D.
Publikováno v:
Cell Transplantation, Vol 15 (2006)
Successful immunosuppressive therapy is critical for liver transplantation. However, a considerable number of patients show clinical resistance to the therapy and experience rejection episodes, or alternatively exhibits serious adverse effects of dru
Externí odkaz:
https://doaj.org/article/4f21b7c4817d4c95bb055e8bd6112608
Autor:
Sachiko Tanaka, Kentaro Sugiyama, Tetsuji Sawada, Xiaoqin Wang, Koichiro Tahara, Shuhe Chen, Toshihiko Hirano, Wencheng Xu, Hongguang Wu
Publikováno v:
Fundamental & Clinical Pharmacology. 35:832-842
BACKGROUND Methotrexate (MTX) is used as anchor drug for patients with early and established rheumatoid arthritis (RA). Vitamin K2 administration was also reported to be associated with decreased disease activity in RA. OBJECTIVES Immunosuppressive p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b565d5c62199b9fc200a347744d759bc
https://doi.org/10.1111/fcp.12676
https://doi.org/10.1111/fcp.12676
Autor:
Shuhe Chen, Xiaoqin Wang, Tetsuji Sawada, Hongguang Wu, Koichiro Tahara, Kentaro Sugiyama, Sachiko Tanaka, Wencheng Xu, Toshihiko Hirano
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 59:55-62
OBJECTIVE To investigate the immunosuppressive effect of vitamin K2 against mitogen-activated peripheral blood mononuclear cells (PBMCs) of rheumatoid arthritis (RA) patients. MATERIALS AND METHODS Concanavalin A-stimulated PBMC culture procedure was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c272d7fdc671ce1c57c405c213946d53
https://doi.org/10.5414/cp203827
https://doi.org/10.5414/cp203827