Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Toshihiko Ezashi"'
Autor:
Jie Zhou, Yuchen Tian, Ying Qu, Madyson Williams, Ye Yuan, Rowan M. Karvas, Megan A. Sheridan, Laura C. Schulz, Toshihiko Ezashi, Michael R. Roberts, Danny J. Schust
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The placenta acts as a protective barrier to pathogens and other harmful substances present in the maternal circulation throughout pregnancy. Disruption of placental development can lead to complications of pregnancy such as preeclampsia, intrauterin
Externí odkaz:
https://doaj.org/article/ef4317e854f24c9fbdf2b85ad558ca16
Autor:
Sureni V. Mullegama, Steven D. Klein, Stephen R. Williams, Jeffrey W. Innis, Frank J. Probst, Chad Haldeman-Englert, Julian A. Martinez-Agosto, Ying Yang, Yuchen Tian, Sarah H. Elsea, Toshihiko Ezashi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract MBD5-associated neurodevelopmental disorder (MAND) is an autism spectrum disorder (ASD) characterized by intellectual disability, motor delay, speech impairment and behavioral problems; however, the biological role of methyl-CpG-binding doma
Externí odkaz:
https://doaj.org/article/e6d18d28ad8c4705b934f15392ca5b20
Autor:
Teka Khan, Arun S. Seetharam, Jie Zhou, Nathan J. Bivens, Danny J. Schust, Toshihiko Ezashi, Geetu Tuteja, R. Michael Roberts
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
One model to study the emergence of the human trophoblast (TB) has been the exposure of pluripotent stem cells to bone morphogenetic protein 4 (BMP4) in presence of inhibitors of ACTIVIN/TGFB; A83–01 and FGF2; PD173074 (BAP), which generates a mixt
Externí odkaz:
https://doaj.org/article/79713f32821b42e1869fd77e08ac5dc7
Autor:
Wei Wang, Sang Joon Lee, Patrick A. Scott, Xiaoqin Lu, Douglas Emery, Yongqin Liu, Toshihiko Ezashi, Michael R. Roberts, Jason W. Ross, Henry J. Kaplan, Douglas C. Dean
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 372-385 (2016)
Most retinitis pigmentosa (RP) mutations arise in rod photoreceptor genes, leading to diminished peripheral and nighttime vision. Using a pig model of autosomal-dominant RP, we show glucose becomes sequestered in the retinal pigment epithelium (RPE)
Externí odkaz:
https://doaj.org/article/98565b9514e64757a3d007c17b420beb
Autor:
Megan A Sheridan, Velmurugan Balaraman, Danny J Schust, Toshihiko Ezashi, R Michael Roberts, Alexander W E Franz
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200086 (2018)
Zika virus (ZIKV) drew worldwide attention when a recent epidemic was linked to fetal microcephaly. Here we used human embryonic stem cell derived trophoblasts as a model for primitive placental trophoblast to test the hypothesis that there are diffe
Externí odkaz:
https://doaj.org/article/11424b9e876242bc8a08c9a17828b20c
Autor:
Penghua Yang, Aihua Dai, Andrei P Alexenko, Yajun Liu, Amanda J Stephens, Laura C Schulz, Danny J Schust, R Michael Roberts, Toshihiko Ezashi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103110 (2014)
Signs of severe oxidative stress are evident in term placentae of infants born to mothers with preeclampsia (PE), but it is unclear whether this is a cause or consequence of the disease. Here fibroblast lines were established from umbilical cords (UC
Externí odkaz:
https://doaj.org/article/b436ea367758428c96a53879e33156f1
Autor:
Arun S. Seetharam, Ha T.H. Vu, Sehee Choi, Teka Khan, Megan A. Sheridan, Toshihiko Ezashi, R. Michael Roberts, Geetu Tuteja
Publikováno v:
Stem Cell Reports. 17:1289-1302
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b87000a070e0359b82b35a05e51298b0
https://doi.org/10.1016/j.stemcr.2022.04.014
https://doi.org/10.1016/j.stemcr.2022.04.014
Autor:
Toshihiko Ezashi, Laura C. Schulz, Jie Zhou, Teka Khan, Danny J. Schust, R. Michael Roberts, Jun Sugimoto
Publikováno v:
Placenta. 113:8-14
Three versions of syncytiotrophoblast exist in the human placenta: an invasive type associated with the implanting conceptus, non-invasive villous type of definitive placenta, and placental bed giant cells. Syncytins are encoded by modified env genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcb1c0879aaa6830e9b620f7ebf3ab1
https://doi.org/10.1016/j.placenta.2021.01.006
https://doi.org/10.1016/j.placenta.2021.01.006
Autor:
Leqian Yu, Toshihiko Ezashi, Yulei Wei, Jialei Duan, Deirdre Logsdon, Linfeng Zhan, Asrafun Nahar, Carlos A. Pinzon Arteaga, Lizhong Liu, Caitlen Stobbe, Mandy Katz-Jaffe, William B Schoolcraft, Lei Wang, Tao Tan, Gary C. Hon, Ye Yuan, Jun Wu
SUMMARYRecent advances in human blastoids generated from naïve pluripotent stem cells have opened a new avenue for modelling early human development and implantation. Despite the success, however, existing protocols have several limitations, e.g., t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef1a436e1a873e64ebd97ed5361d0966
https://doi.org/10.1101/2022.09.14.507946
https://doi.org/10.1101/2022.09.14.507946
Autor:
R. Michael Roberts, Toshihiko Ezashi, Jasmine Temple, Joseph R. Owen, Francesca Soncin, Mana M. Parast
Publikováno v:
Cellular and molecular life sciences : CMLS, vol 79, iss 8
Cell Mol Life Sci
Cell Mol Life Sci
The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has also been implicated in development of extraembryonic lineages, including trop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc12644b73a9e5a3c7d669396ca1bc5
https://escholarship.org/uc/item/7rm3x068
https://escholarship.org/uc/item/7rm3x068