Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Toshihiko Aki"'
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 2020-2029 (2022)
The aim of this study is to examine the effects of wild type as well as a mutant (A53T) form of α-synuclein (α-syn) on neuronal cells exposed to methamphetamine (METH). SH-SY5Y human dopaminergic neuronal cells stably expressing exogenously added w
Externí odkaz:
https://doaj.org/article/1341c12fea5c4323b65b254e14b4f98e
Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Abuse of the potent psychostimulant cocaine is widely established to have cardiovascular consequences. The cardiotoxicity of cocaine is mainly associated with oxidative stress and mitochondrial dysfunction. Mitochondrial dynamics and biogene
Externí odkaz:
https://doaj.org/article/a3f51704158e48a986e5e691faf65441
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 980-987 (2021)
Cannabinoids are some of the most popular recreationally used illicit drugs, and are frequently consumed along with alcoholic beverages. Although the whole body effects of cannabinoids depend largely on their effects on the central nerve system, cann
Externí odkaz:
https://doaj.org/article/5e2897ecc955419a8ec99d470b06060f
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277032 (2022)
Cocaine abuse has a negative impact on the immune system. To investigate the adverse effects of binge cocaine administration on lymphoid organs such as thymus and spleen, we examined the effects of repeated intravenous (i.v.) administration of cocain
Externí odkaz:
https://doaj.org/article/629dbb2ec4c84584a2f653f9882dafc9
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252853 (2021)
The purpose of this study is to examine the effect of repeated cocaine administration on the whole body of rats. Rats (male, 6 weeks old, Sprague Dawley) were injected intraperitoneally with cocaine (50 mg/kg) once a day for 1, 3 or 7 days, and major
Externí odkaz:
https://doaj.org/article/67c8be7553574ee693abc06093ddc539
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Ferroptosis is a newly discovered form of necrotic cell death characterized by its dependency on iron and lipid peroxidation. Ferroptosis has attracted much attention recently in the area of neurodegeneration since the involvement of ferroptosis in P
Externí odkaz:
https://doaj.org/article/0b8293e1e89d47c384ab9c14c643d01f
Publikováno v:
Heliyon, Vol 6, Iss 11, Pp e05503- (2020)
The aim of this study is to examine the molecular mechanism of cytotoxicity caused by direct exposure to short chain alcohol. We showed previously that exposing H9c2 cardiomyoblastoma cells to 150 mM 1-butanol results in cell death within 1 h through
Externí odkaz:
https://doaj.org/article/1381441a62cd4f29b1aa929d1c4060f6
Publikováno v:
Antioxidants, Vol 11, Iss 1, p 126 (2022)
Oxidative stress, a result of a disturbance in redox homeostasis, is considered to be one of the main aggravating events in the pathogenesis of immune disorders. Peroxiredoxins (Prdxs) are an enzyme family that catalyzes the reduction of peroxides, i
Externí odkaz:
https://doaj.org/article/273a279a834a4432b540dee2cff55c1c
Publikováno v:
Cell Stress, Vol 1, Iss 2, Pp 79-89 (2017)
Recent research indicates crucial roles of autophagy during sepsis. In animal models of sepsis induced by cecal ligation and puncture (CLP) or the systemic administration of lipopolysaccharides (LPS), autophagy is implicated in the activation and/or
Externí odkaz:
https://doaj.org/article/6f80fcd36f3b40d0b822a3c8ca2ef52a
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210474 (2019)
CORM-3 is a water-soluble carbon monoxide (CO)-releasing molecule developed for possible therapeutic use of CO. CORM-3 belongs to a group of metal carbonyl compounds that contain transition metals and carbonyls as the central scaffold and coordinated
Externí odkaz:
https://doaj.org/article/2d196a4b608646a3a3451b01e559546b