Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Toshiharu Natsume"'
Autor:
Hiroshi Kumagai, Su-Jeong Kim, Brendan Miller, Hirofumi Zempo, Kumpei Tanisawa, Toshiharu Natsume, Shin Hyung Lee, Junxiang Wan, Naphada Leelaprachakul, Michi Emma Kumagai, Ricardo Ramirez, II, Hemal H. Mehta, Kevin Cao, Tae Jung Oh, James A. Wohlschlegel, Jihui Sha, Yuichiro Nishida, Noriyuki Fuku, Shohei Dobashi, Eri Miyamoto-Mikami, Mizuki Takaragawa, Mizuho Fuku, Toshinori Yoshihara, Hisashi Naito, Ryoko Kawakami, Suguru Torii, Taishi Midorikawa, Koichiro Oka, Megumi Hara, Chiharu Iwasaka, Yosuke Yamada, Yasuki Higaki, Keitaro Tanaka, Kelvin Yen, Pinchas Cohen
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111212- (2024)
Summary: MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to CK2 and activates it in cell-free systems. MOTS-c administration to mice prevente
Externí odkaz:
https://doaj.org/article/9c8eb5228eec4499b6a78ec85413ec62
Autor:
Tetsuro Tamaki, Toshiharu Natsume, Akira Katoh, Atsuko Shigenari, Takashi Shiina, Nobuyuki Nakajima, Kosuke Saito, Tsuyoshi Fukuzawa, Masayoshi Otake, Satoko Enya, Akihisa Kangawa, Takeshi Imai, Miyu Tamaki, Yoshiyasu Uchiyama
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 939 (2024)
Pig skeletal muscle-derived stem cells (SK-MSCs) were transplanted onto the common peroneal nerve with a collagen tube as a preclinical large animal experiment designed to address long nerve gaps. In terms of therapeutic usefulness, a human family ca
Externí odkaz:
https://doaj.org/article/1e04b99c2fbb4871ad4c3862f0e5ce34
Autor:
Pengyu Deng, Hayao Ozaki, Toshiharu Natsume, Dandan Ke, Dajiang Lu, Koya Suzuki, Hisashi Naito
Publikováno v:
Children, Vol 10, Iss 9, p 1538 (2023)
Purpose: Physical activity (PA) is likely to be the most important modifiable factor in skeletal muscle development. However, the influence of PA on the skeletal muscle of preschool children has not been thoroughly investigated. The main objective of
Externí odkaz:
https://doaj.org/article/ba7565068fc14d948c32dc099cc5b8f9
Autor:
Shuji Sawada, Hayao Ozaki, Toshiharu Natsume, Daiki Nakano, Pengyu Deng, Toshinori Yoshihara, Takuya Osawa, Hiroyuki Kobayashi, Shuichi Machida, Hisashi Naito
Publikováno v:
BMC Geriatrics, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Resistance training has been recommended as an effective measure against age-related loss of muscle mass and muscle strength, called sarcopenia, even in older adults. However, despite subjecting each participant to the same traini
Externí odkaz:
https://doaj.org/article/a0dde033a9594f9e95e62cea91dc7569
Autor:
Shuji Sawada, Hayao Ozaki, Toshiharu Natsume, Pengyu Deng, Toshinori Yoshihara, Takashi Nakagata, Takuya Osawa, Yoshihiko Ishihara, Tomoharu Kitada, Ken Kimura, Nobuhiro Sato, Shuichi Machida, Hisashi Naito
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-6 (2021)
Abstract Background Low muscle strength has been focused on as an essential characteristic of sarcopenia, and the 30-s chair stand test (CS-30) could be a particularly useful test for assessing muscle strength. While it is speculated to be a benefici
Externí odkaz:
https://doaj.org/article/ba2f763d489c48aabfb5a57ab517563a
Autor:
Shuo-Wen Chang, Toshinori Yoshihara, Takamasa Tsuzuki, Toshiharu Natsume, Ryo Kakigi, Shuichi Machida, Hisashi Naito
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0264171 (2022)
We investigated whether time-of-day dependent changes in the rat soleus (SOL) muscle size, after eccentric exercises, operate via the mechanistic target of rapamycin (mTOR) signaling pathway. For our first experiment, we assigned 9-week-old male Wist
Externí odkaz:
https://doaj.org/article/61826d89c397403ea032ee50b36e2b91
Autor:
Pengyu Deng, Hayao Ozaki, Toshiharu Natsume, Yoshihiko Ishihara, Dandan Ke, Koya Suzuki, Hisashi Naito
Publikováno v:
Children, Vol 10, Iss 3, p 455 (2023)
Purpose: Physical activity (PA) is widely recognized as a key factor in promoting skeletal muscle growth, though little is known about the specific impact of PA on the skeletal muscle development of preschool children. The purpose of this study is to
Externí odkaz:
https://doaj.org/article/cb827ae6c40b477dbe24a904fdee37a6
Autor:
Toshinori Yoshihara, Hayao Ozaki, Takashi Nakagata, Toshiharu Natsume, Tomoharu Kitada, Yoshihiko Ishihara, Shuji Sawada, Masayoshi Ishibashi, Hiroyuki Kobayashi, Shuichi Machida, Hisashi Naito
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Locomotive syndrome (LS) is associated with weakness and loss of function in the musculoskeletal organs. We aimed to determine the association between LS components and blood parameters in middle-aged and elderly individuals. Meth
Externí odkaz:
https://doaj.org/article/d95f17e34d244aeeb9f69e271bd914b5
Autor:
Hayao Ozaki, Takashi Abe, Scott J. Dankel, Jeremy P. Loenneke, Toshiharu Natsume, Pengyu Deng, Hisashi Naito
Publikováno v:
Children, Vol 8, Iss 1, p 9 (2020)
It is unclear whether the measurement of maximum muscle strength in younger children can be performed accurately due to factors such as motivation and maturity (i.e., the ability to receive instruction). If there is a large change in a ratio between
Externí odkaz:
https://doaj.org/article/b71a6bdf1d7943c39b7043c171248041
Autor:
Hiroshi Kumagai, Su-Jeong Kim, Miller, Brendan, Toshiharu Natsume, Junxiang Wan, Kumagai, Michi Emma, Ramirez II, Ricardo, Shin Hyung Lee, Ayaka Sato, Mehta, Hemal H., Yen, Kelvin, Cohen, Pinchas
Publikováno v:
American Journal of Physiology: Endocrinology & Metabolism; Mar2024, Vol. 326 Issue 3, pE207-E214, 8p