Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Toshiharu Ishizuka"'
Publikováno v:
Diabetol Int
We herein report the clinical course of a 56-year-old Japanese patient with slowly progressive type 1 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, and severe insulin resistance. The patient’s intravenous glucose toleran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356facdb3645f25c57051de3fd325438
https://doi.org/10.1007/s13340-020-00448-4
https://doi.org/10.1007/s13340-020-00448-4
Autor:
Yoshiharu Tokuyama, Atsuya Horie, Sumihiko Sato, Yukiko Hatanaka, Azuma Kanatsuka, Toshiharu Ishizuka
Publikováno v:
Diabetology International. 7:432-439
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in Japan. The clinical course and factors related to the progression of DKD to ESRD are important issues when treating patients with DKD.Ninety-one type 2 diabetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe5e0cd848e737b3e2e427d15c0eac8
https://doi.org/10.1007/s13340-016-0270-2
https://doi.org/10.1007/s13340-016-0270-2
Autor:
Haruhiko Osawa, Hideichi Makino, Kana Matsui, Toshiharu Ishizuka, Azuma Kanatsuka, Toru Egashira, Hiroshi Onuma, Yoshiharu Tokuyama
Publikováno v:
Metabolism. 56:693-698
Impaired insulin secretion and decreased insulin sensitivity are the main pathophysiologic features responsible for development of hyperglycemia in type 2 diabetes mellitus. Insulin resistance is often associated with increased adipose tissue mass. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2b105a88f18cf670941a6a6baf2da
https://doi.org/10.1016/j.metabol.2006.12.019
https://doi.org/10.1016/j.metabol.2006.12.019
Autor:
Yoshiharu Tokuyama, Azuma Kanatsuka, Toshiharu Ishizuka, Toru Egashira, Osamu Nozaki, Kana Matsui
Publikováno v:
Diabetes Research and Clinical Practice. 66:63-69
To address the possibility that the partial disruption of Glucagon-like peptide-1 (GLP-1) signaling could cause diabetes, we tried to detect the mutation in GLP-1 receptor (GLP-1R) gene in the population with type 2 diabetes. Genomic DNA was extracte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd275c6ef1b747d9b09cd1e76053bc72
https://doi.org/10.1016/j.diabres.2004.02.004
https://doi.org/10.1016/j.diabres.2004.02.004
Publikováno v:
IUBMB Life. 44:1059-1067
The behavior of phosphoribosylpyrophosphate (PRPP) synthetase during the cell cycle was studied using RSa cells derived from human fetal fibroblasts. The cells were synchronized by the double thymidine block method. PRPP synthetase activity in cell e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a055ed3ce1b16a4c719a43785bc2f290
https://doi.org/10.1080/15216549800202122
https://doi.org/10.1080/15216549800202122
Autor:
Yuichi Morishima, Toshiyuki Sugiura, Tsuguhiko Tashiro, Nobuyuki Nakajima, Hidetoshi Ino, Naganori Hayashi, Masamiti Tatibana, Katsunori Furukawa, Hiroshi Nitta, Yoshihisa Otsubo, Isao Ito, Hideo Yamamori, Toshiharu Ishizuka
Publikováno v:
Nutrition. 13:783-787
The purpose of the study was to investigate the effect of insulin-like growth factor-1 (IGF-1) on the translocation of endotoxin from the gut of burned rats. Twenty-eight male Sprague-Dawley rats (7-wk-old) were subjected to 20% full-thickness scald
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b6482b18ee6290141185b90fff95a
https://doi.org/10.1016/s0899-9007(97)00189-5
https://doi.org/10.1016/s0899-9007(97)00189-5
Publikováno v:
Internal medicine (Tokyo, Japan). 52(24)
We herein report the case of a patient with slowly progressive type 1 diabetes and insulin independence lasting for >10 years despite the detection of continuously elevated glutamic acid decarboxylase autoantibody titers. We monitored the patient's c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9341bb1ab3a90a14e51e53e2ab2fa39
https://pubmed.ncbi.nlm.nih.gov/24334584
https://pubmed.ncbi.nlm.nih.gov/24334584
Autor:
Tomoko Sonoda, Toshiharu Ishizuka, Masamiti Tatibana, Nobuo Suzuki, Kunio Sawa, Sumio Ishijima, Kazuko Kita
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1306:27-30
A human cDNA encoding a human homologue of the rat phosphoribosylpyrophosphate synthetase-associated protein of 39 kDa was isolated. The deduced protein contains 356 amino acids and has a calculated molecular mass of 38561. The amino acid sequence is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a123df2fcde7d7533f5cbe378f161c
https://doi.org/10.1016/0167-4781(96)00030-9
https://doi.org/10.1016/0167-4781(96)00030-9
Publikováno v:
Gene. 166:267-271
While cyclin-dependent kinases, such as CDC2 and CDK2, are key regulators of cell-cycle progression, cyclin-dependent kinase 5 (CDK5) is highly expressed in mature neurons with no evident cell-cycle regulation. The 5'-region of the mouse CDK5 gene wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732eae2874507bec9b4849372ca89562
https://doi.org/10.1016/0378-1119(95)00650-8
https://doi.org/10.1016/0378-1119(95)00650-8
Publikováno v:
Journal of Biological Chemistry. 269:8334-8340
The rat liver phosphoribosylpyrophosphate (PRPP) synthetase exists as complex aggregates composed of the 34-kDa catalytic subunits (PRS I and II) and other 39- and 41-kDa proteins (Kita, K., Otsuki, T., Ishizuka, T., and Tatibana, M. (1989) J. Bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273a9eb8ace1456dbc19acea2a2b6b94
https://doi.org/10.1016/s0021-9258(17)37198-3
https://doi.org/10.1016/s0021-9258(17)37198-3