Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Toshifumi Morimura"'
Autor:
Ryota Hikiami, Toshifumi Morimura, Takashi Ayaki, Tomoyuki Tsukiyama, Naoko Morimura, Makiko Kusui, Hideki Wada, Sumio Minamiyama, Akemi Shodai, Megumi Asada-Utsugi, Shin-ichi Muramatsu, Takatoshi Ueki, Ryosuke Takahashi, Makoto Urushitani
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Genetic mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). Although mitochondrial dysfunction and stress granule have been crucially implicated in FUS proteinopathy, the molecular basis remains unclear. Here, we s
Externí odkaz:
https://doaj.org/article/466c0b9b2b744c3492877408d329cf97
Autor:
Megumi Asada-Utsugi, Kengo Uemura, Takashi Ayaki, Maiko T. Uemura, Sumio Minamiyama, Ryota Hikiami, Toshifumi Morimura, Akemi Shodai, Takatoshi Ueki, Ryosuke Takahashi, Ayae Kinoshita, Makoto Urushitani
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Phosphorylated microtubule-associated protein tau (p-tau) accumulates at double-strand breaks (DSBs) in neurons. Loss of tau induces failure of DSB repair and excessive DSB accumulation, leading to aberrant p-tau aggregation and apoptotic neurons.
Externí odkaz:
https://doaj.org/article/de0adf46df324e2681f7db4538e8e628
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3635 (2020)
Aberrant angiogenesis is a pathological feature of a number of diseases and arises from the uncoordinated expression of angiogenic factors as response to different cellular stresses. Age-related macular degeneration (AMD), a leading cause of vision l
Externí odkaz:
https://doaj.org/article/396e6704de914481a8baec775cf529ad
Autor:
Akemi Shodai, Akemi Ido, Noriko Fujiwara, Takashi Ayaki, Toshifumi Morimura, Miki Oono, Tsukasa Uchida, Ryosuke Takahashi, Hidefumi Ito, Makoto Urushitani
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52776 (2012)
Accumulating evidence suggests that pathogenic TAR DNA-binding protein (TDP)-43 fragments contain a partial RNA-recognition motif domain 2 (RRM2) in amyotrophic lateral sclerosis (ALS)/frontotemporal lobar degeneration. However, the molecular basis f
Externí odkaz:
https://doaj.org/article/f31541792e8d4eaba61f59ca2d2e04d7
Autor:
Hideki Wada, Ryota Hikiami, Makiko Kusui, Sumio Minamiyama, Megumi Asada-Utsugi, Akemi Shodai, Shin-ichi Muramatsu, Toshifumi Morimura, Makoto Urushitani
Publikováno v:
Neuroscience research.
Mislocalization and aggregate formation of TAR DNA-biding protein of 43kD (TDP-43) in the cytoplasm are signatures of amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration (FTLD). However, the role of two cytopathologies in ALS/FTL
Autor:
Tomoyuki Tsukiyama, Yasunari Seita, Masanaga Muto, Masaki Nishimura, Chizuru Iwatani, Ikuo Tooyama, Hideaki Tsuchiya, Toshifumi Morimura, Naoki Watanabe, Toshiharu Suzuki, Shinichiro Nakamura, Daijiro Yanagisawa, Masatsugu Ema, Eiichi Okamura, Masataka Nakaya
Publikováno v:
Journal of Alzheimer's Disease
Alzheimer's disease (AD) is the most common cause of dementia and understanding its pathogenesis should lead to improved therapeutic and diagnostic methods. Although several groups have developed transgenic mouse models overexpressing the human amylo
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3635, p 3635 (2020)
Volume 21
Issue 10
International Journal of Molecular Sciences, Vol 21, Iss 3635, p 3635 (2020)
Volume 21
Issue 10
Aberrant angiogenesis is a pathological feature of a number of diseases and arises from the uncoordinated expression of angiogenic factors as response to different cellular stresses. Age-related macular degeneration (AMD), a leading cause of vision l
Autor:
Rina Takahashi, Akemi Ido, Shigeyuki Yokoyama, Makoto Urushitani, Tsukasa Uchida, Ryo Kitahara, Ryosuke Takahashi, Soichiro Kitazawa, Yutaka Muto, Takanori Kigawa, Toshifumi Morimura, S. Suzuki, Takashi Ayaki, Noriko Fujiwara, Hidefumi Ito, Akemi Shodai, Mikako Shirouzu
Publikováno v:
Journal of Biological Chemistry. 288:14886-14905
Aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is a pathological signature of amyotrophic lateral sclerosis (ALS). Although accumulating evidence suggests the involvement of RNA recognition motifs (RRMs) in TDP-43 proteinopathy, it remains
Autor:
Ken Inoue, Toshifumi Morimura, Yurika Numata, Eriko Hirano, Yu ich Goto, Shoko Nakamura, Shigeo Kure
Publikováno v:
Journal of Biological Chemistry. 288:7451-7466
Missense mutations in the proteolipid protein 1 (PLP1) gene cause a wide spectrum of hypomyelinating disorders, from mild spastic paraplegia type 2 to severe Pelizaeus-Merzbacher disease (PMD). Mutant PLP1 accumulates in the endoplasmic reticulum (ER
Autor:
Yoshitaka Tamaki, Naomi Sakashita, Toshifumi Morimura, Ryosuke Takahashi, Hidefumi Ito, Kazuchika Nishitsuji, Hirofumi Yamashita, Akemi Shodai, Makoto Urushitani, Tsukasa Uchida, Takashi Ayaki, Seiji Kaji, Yoshinori Banno, Takakuni Maki
Publikováno v:
Scientific Reports
The molecular machinery responsible for cytosolic accumulation of misfolded TDP-43 in amyotrophic lateral sclerosis (ALS) remains elusive. Here we identified a cullin-2 (CUL2) RING complex as a novel ubiquitin ligase for fragmented forms of TDP-43. T