Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Toshifumi Asaka"'
1
Synthesis and Antibacterial Activity of a Novel Series of Acylides: 3-O-(3-Pyridyl)acetylerythromycin A Derivatives
Autor: Kazuya Kameo, Masato Kashimura, Atsushi Nishida, Masakazu Sato, Toshifumi Asaka, Shigeo Morimoto, Hiroyuki Sugiyama, Tetsuya Tanikawa, Keiko Suzuki
Publikováno v: Journal of Medicinal Chemistry. 46:2706-2715
A novel series of acylides, 3-O-(aryl)acetylerythromycin A derivatives, were synthesized and evaluated. These compounds have significant potent antibacterial activity against not only Gram-positive pathogens, including inducibly macrolide-lincosamide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d227f168bfad640d5cb4d94d8aa2b29a
https://doi.org/10.1021/jm020568d
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2
Recent Developments in Macrolide Antimicrobial Research
Autor: Hiroyuki Sugiyama, Toshifumi Asaka, Akira Manaka
Publikováno v: Current Topics in Medicinal Chemistry. 3:961-989
Clarithromycin and azithromycin, which are more acid-stable than erythromycin A (EM), have been widely prescribed for the treatment of respiratory tract infections because of their high efficacy and safety. However, these macrolide antibiotics are on
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644dd96904d6627b59c96ce37bdc213
https://doi.org/10.2174/1568026033452140
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4
ChemInform Abstract: Chemical Modification of Erythromycins. Part 11. Synthesis of Clarithromycin (6-O-Methylerythromycin A) via Erythromycin. A Quaternary Ammonium Salt Derivative
Autor: Yoshiaki Watanabe, Toshifumi Asaka, Masato Kashimura, Shigeo Morimoto, Takashi Adachi
Publikováno v: ChemInform. 24
Synthesis of clarithromycin via quaternary ammonium salt of erythromycin A, 2'-O-benzyl-3'-[benzyl(dimethyl)ammonio)-3'- de(dimethylamino)erythromycin A bromide 9-O-(benzyloxime) (2), was reported. Clarithromycin was obtained in 53 % overall yield fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dad9f4cece46e7392b61fae119dc93a
https://doi.org/10.1002/chin.199314295
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7
Chemical modification of erythromycins. VI. Structure and antibacterial activity of acid degradation products of 6-O-methylerythromycins A
Autor: Toshifumi Asaka, Yoko Misawa, Hldeaki Kondoh, Shigeo Morimoto, Yoshiaki Watanabe
Publikováno v: The Journal of Antibiotics. 43:570-573
We describe the structure and antibacterial activity of the degradation products of 6-O-methylerythromycin A and its derivatives under acidic conditions.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c6a21ee43870d58390c4dca26226e1
https://doi.org/10.7164/antibiotics.43.570
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9
In vitro and in vivo antibacterial activities of the tricyclic ketolide TE-802 and its analogs
Autor: Toshi Akashi, Rika Oyauchi, Toshifumi Asaka, Keiko Suzuki, Junko Miyachi, Takeo Ono, Shigeo Morimoto, Hiroshi Ikuta, Hiroyuki Kawauchi, Masato Kashimura
Publikováno v: The Journal of antibiotics. 57(8)
The in vitro and in vivo antibacterial activities of tricyclic ketolides (TKs: TE-802, TE-806, TE-935, TE-943) have been compared with those of clarithromycin (CAM), azithromycin (AZM) and rokitamycin (RKM). TKs were active against not only erythromy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839388e812ee695d67ef508ab8715e00
https://pubmed.ncbi.nlm.nih.gov/15515889
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