Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Toshifumi AZUMA"'
Autor:
Shoko Onodera, Nana Morita, Yuriko Nakamura, Shinichi Takahashi, Kazuhiko Hashimoto, Takeshi Nomura, Akira Katakura, Kenjiro Kosaki, Toshifumi Azuma
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-7 (2021)
Abstract Background Basal cell carcinoma (BCC) is the most commonly occurring neoplasm in patients with Gorlin syndrome. It is widely accepted that multiple basal cell carcinomas simultaneously develop in middle-aged patients with this syndrome. Howe
Externí odkaz:
https://doaj.org/article/9758cb90a51442a99ae702029e19ebd8
Autor:
Denise Zujur, Kosuke Kanke, Shoko Onodera, Shoichiro Tani, Jenny Lai, Toshifumi Azuma, Xiaonan Xin, Alexander C. Lichtler, David W. Rowe, Taku Saito, Sakae Tanaka, Hideki Masaki, Hiromitsu Nakauchi, Ung-il Chung, Hironori Hojo, Shinsuke Ohba
Publikováno v:
Regenerative Therapy, Vol 14, Iss , Pp 19-31 (2020)
Clinically relevant human induced pluripotent stem cell (hiPSC) derivatives require efficient protocols to differentiate hiPSCs into specific lineages. Here we developed a fully defined xeno-free strategy to direct hiPSCs toward osteoblasts within 21
Externí odkaz:
https://doaj.org/article/06a2c4f04f66498f94f1a291761848bf
Autor:
Hiroshi Kato, Katsuhito Watanabe, Akiko Saito, Shoko Onodera, Toshifumi Azuma, Masayuki Takano
Publikováno v:
Journal of Applied Oral Science, Vol 30 (2022)
Abstract Stem cell-based regeneration therapy offers new therapeutic options for patients with bone defects because of significant advances in stem cell research. Although bone marrow mesenchymal stem cells are the ideal material for bone regeneratio
Externí odkaz:
https://doaj.org/article/73f34298c649402c94deb8ddd77051bb
Autor:
Mayumi Matsunaga, Maki Kimura, Takehito Ouchi, Takashi Nakamura, Sadao Ohyama, Masayuki Ando, Sachie Nomura, Toshifumi Azuma, Tatsuya Ichinohe, Yoshiyuki Shibukawa
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting i
Externí odkaz:
https://doaj.org/article/be106eed949b4836a2c5fdc281214010
Autor:
Katsuhito Watanabe, Takashi Nakamura, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma
Publikováno v:
Tumor Biology, Vol 42 (2020)
A missense mutation of the guanine nucleotide binding protein alpha stimulating activity polypeptide 1 ( GNAS ) gene, typically Arg201Cys or Arg201His (R201H/R201C), leads to constitutive activation of the Gsα-cyclic AMP (cAMP) signaling pathway tha
Externí odkaz:
https://doaj.org/article/b4725df9286049af990e1ba2838e07d8
Autor:
Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, Takahito Okudaira, Katsuhito Watanabe, Hiroshi Kato, Takeshi Onda, Akira Watanabe, Kenjiro Kosaki, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Teruo Sakamoto, Akira Yamaguchi, Kenji Sueishi, Toshifumi Azuma
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2018)
Abstract Background Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At present, as a therapeutic
Externí odkaz:
https://doaj.org/article/ce9b936bf4274cf0a5bc559c3dec8416
Autor:
Shoko Onodera, Akiko Saito, Daigo Hasegawa, Nana Morita, Katsuhito Watanabe, Takeshi Nomura, Takahiko Shibahara, Shinsuke Ohba, Akira Yamaguchi, Toshifumi Azuma
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184702 (2017)
Gorlin syndrome is a genetic disorder of autosomal dominant inheritance that predisposes the affected individual to a variety of disorders that are attributed largely to heterozygous germline patched1 (PTCH1) mutations. PTCH1 is a hedgehog (Hh) recep
Externí odkaz:
https://doaj.org/article/10bfe564478f4eb8a973a4e26c83a8e4
Autor:
Daigo Hasegawa, Hiromi Ochiai-Shino, Shoko Onodera, Takashi Nakamura, Akiko Saito, Takeshi Onda, Katsuhito Watanabe, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Kenjiro Kosaki, Akira Yamaguchi, Takahiko Shibahara, Toshifumi Azuma
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186879 (2017)
Gorlin syndrome is an autosomal dominant inherited syndrome that predisposes a patient to the formation of basal cell carcinomas, odontogenic keratocysts, and skeletal anomalies. Causative mutations in several genes associated with the sonic hedgehog
Externí odkaz:
https://doaj.org/article/de56c70d98ea4d51b1043a0339cbac90
Publikováno v:
Journal of Oral Microbiology, Vol 5, Iss 0, Pp 1-8 (2013)
Background: The malQ and glgP genes, respectively, annotated as putative 4-α-glucanotransferase and putative glycogen phosphorylase are located with a 29 nucleotide overlap on the Streptococcus mutans genome. We found that the glgP gene of this orga
Externí odkaz:
https://doaj.org/article/1d32001cc4b3454ab06998303fcb0431
Publikováno v:
Journal of Oral Microbiology, Vol 3, Iss 0, Pp 1-8 (2011)
Background: Streptococcus mutans surface-protein antigen (SpaP, PAc, or antigen I/II) has been well known to play an important role in initial attachment to tooth surfaces. However, strains with weak SpaP-expression were recently reported to be found
Externí odkaz:
https://doaj.org/article/266aecefb04a4d6c89ca681939c4c41f