Zobrazeno 1 - 10
of 1 327
pro vyhledávání: '"Toshifumi, Hibi"'
Autor:
Ryo Karashima, Shintaro Sagami, Yoko Yamana, Masa Maeda, Aya Hojo, Yusuke Miyatani, Masaru Nakano, Takahisa Matsuda, Toshifumi Hibi, Taku Kobayashi
Publikováno v:
Intestinal Research, Vol 22, Iss 4, Pp 473-483 (2024)
Background/Aims Leucine-rich α-2-glycoprotein (LRG) is a new serum biomarker reflecting the disease activity of ulcerative colitis (UC), but its change during the acute phase has not been enough investigated. Methods Patients with UC who initiated t
Externí odkaz:
https://doaj.org/article/96d6e93c28974af18c10dd46144b5fb7
Autor:
Taku Kobayashi, Katsuyoshi Matsuoka, Mamoru Watanabe, Tadakazu Hisamatsu, Fumihito Hirai, Joe Milata, Xingyuan Li, Nathan Morris, Vipin Arora, Tomoko Ishizuka, Koji Matsuo, Yoichi Satoi, Catherine Milch, Toshifumi Hibi
Publikováno v:
Intestinal Research, Vol 22, Iss 2, Pp 172-185 (2024)
Background/Aims Mirikizumab is a p19-directed anti-interleukin-23 antibody with potential efficacy against ulcerative colitis (UC). We evaluated the efficacy and safety of mirikizumab in a Japanese subpopulation with moderately to severely active UC
Externí odkaz:
https://doaj.org/article/d73b47e8a614419ea0a3a92df36cd045
Autor:
Kenji Suzuki, Yukinori Sameshima, Junji Yokoyama, Shuji Terai, Hiroyuki Yoneyama, Raja Atreya, Markus F. Neurath, Toshifumi Hibi, Hitoshi Asakura
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-10 (2024)
Abstract Background Carbohydrate sulfotransferase 15 (CHST15) is an enzyme biosynthesizing matrix glycosaminoglycan that modulates tissue remodeling. We evaluated the efficacy of add-on submucosal injections of GUT-1, the RNA oligonucleotide inhibito
Externí odkaz:
https://doaj.org/article/4d12c4d2ddc145778e89ea6704cc7480
Autor:
Hiroki Kiyohara, Hajime Yamazaki, Kei Moriya, Naohiko Akimoto, Shoichiro Kawai, Kento Takenaka, Tomohiro Fukuda, Keiichi Tominaga, Junji Umeno, Shinichiro Shinzaki, Yusuke Honzawa, Tomohisa Takagi, Hitoshi Ichikawa, Toshiyuki Endo, Ryo Ozaki, Akira Andoh, Katsuyoshi Matsuoka, Toshifumi Hibi, Taku Kobayashi
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-10 (2023)
Introduction: Whether white blood cell (WBC) counts are predictors for the effectiveness of thiopurine treatment in ulcerative colitis (UC) has been inconclusive in previous studies with small sample sizes. We investigated the association between WBC
Externí odkaz:
https://doaj.org/article/b333c58cb09c427181f855da5435827a
Autor:
Haruka Wada, Jun Miyoshi, Satoshi Kuronuma, Yuu Nishinarita, Noriaki Oguri, Noritaka Hibi, Osamu Takeuchi, Yoshihiro Akimoto, Sonny T. M. Lee, Minoru Matsuura, Taku Kobayashi, Toshifumi Hibi, Tadakazu Hisamatsu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Although many therapeutic options are available for inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) is still the key medication, particularly for ulcerative colitis (UC). However, the mechanism of action of 5-ASA remains uncl
Externí odkaz:
https://doaj.org/article/dd8ebc128b5a4e8ba43a57f488ea6d90
Autor:
Brian G Feagan, Toshifumi Hibi, Vipul Jairath, Nathan Morris, Bruce E Sands, Marla C Dubinsky, Vipin Arora, April N Naegeli, Trevor Lissoos, Mingyang Shan, Jay Tuttle, Noah Agada
Publikováno v:
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023)
Objective Mirikizumab, a monoclonal antibody targeting the interleukin-23 p19 subunit, was effective in a Phase 2 study (NCT02589665) of moderately-to-severely active ulcerative colitis (UC). We studied mirikizumab’s impact on health-related qualit
Externí odkaz:
https://doaj.org/article/d32d694829724ced8385109aced67187
Publikováno v:
Intestinal Research, Vol 21, Iss 2, Pp 205-215 (2023)
Background/Aims Risks of long-term steroid use in patients with ulcerative colitis (UC) outweigh the benefits, thus dosing should be tapered once a response is achieved. Colonoscopy is a key technique for assessing disease severity and optimizing tre
Externí odkaz:
https://doaj.org/article/7ae2df33bad84705922f8062e81c0100
Autor:
Toshifumi Hibi, Satoshi Motoya, Tadakazu Hisamatsu, Fumihito Hirai, Kenji Watanabe, Katsuyoshi Matsuoka, Masayuki Saruta, Taku Kobayashi, Brian G Feagan, Chantal Tasset, Robin Besuyen, Chohee Yun, Gerald Crans, Jie Zhang, Akira Kondo, Mamoru Watanabe
Publikováno v:
Intestinal Research, Vol 21, Iss 1, Pp 110-125 (2023)
Background/Aims The safety and efficacy of filgotinib, a once-daily oral Janus kinase 1 preferential inhibitor, were evaluated in Japanese patients with ulcerative colitis (UC) in the phase 2b/3 SELECTION trial. Methods SELECTION (NCT02914522) was a
Externí odkaz:
https://doaj.org/article/d7f57edfaba24c2f9b5b590bd3380150
Autor:
Aya Hojo, Taku Kobayashi, Mao Matsubayashi, Hiromu Morikubo, Yusuke Miyatani, Tomohiro Fukuda, Kunio Asonuma, Shintaro Sagami, Masaru Nakano, Takahisa Matsuda, Toshifumi Hibi
Publikováno v:
JGH Open, Vol 6, Iss 8, Pp 547-553 (2022)
Abstract Background and Aim Crohn's disease (CD) often causes intractable diarrhea after intestinal resection. Anion exchange resins have been reported to be effective in patients with bile acid diarrhea after distal ileectomy; furthermore, bile acid
Externí odkaz:
https://doaj.org/article/065dbffec39647068a51c4bd0729a055
Autor:
Naoki Ohmiya, Ichiro Hirata, Hirotsugu Sakamoto, Toshifumi Morishita, Eiko Saito, Katsuyoshi Matsuoka, Tadanobu Nagaya, Shinji Nagata, Miyuki Mukae, Koji Sano, Takayoshi Suzuki, Ken-ichi Tarumi, Seiji Shimizu, Kousaku Kawashima, Toshifumi Hibi, Intractable Diseases, the Health and Labour Sciences Research Group
Publikováno v:
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background Pneumatosis intestinalis (PI) is a rare condition characterized by gas collection in the intestinal wall. We aimed to determine the etiology and affected segments associated with complications, treatment, and outcome. Methods We c
Externí odkaz:
https://doaj.org/article/a0843ee5219a4e1f949b556df2ff3556