Výsledky vyhledávání - "Toshie, Fujishima"

Synthesis and characterization of 20-hydroxyvitamin D3 with the A-ring modification

Autor: Masatoshi Kawahata, Toshie Fujishima, Tsutomu Suenaga, Kentaro Yamaguchi

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 187:27-33

Two novel 20-hydroxyvitamin D3 analogues (4a,b) with the A-ring modification have been synthesized by a convergent manner. An alternative pathway of vitamin D3 metabolism by cytochrome P450scc CYP11A1 was reported to afford 20-hydroxyvitamin D3 (3),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1f05bbf629cf2bafcf3e91891bfce0a
https://doi.org/10.1016/j.jsbmb.2018.10.019

Zobrazit plný text záznamu

Design and concise synthesis of novel vitamin D analogues bearing a functionalized aromatic ring on the side chain

Autor: Masayuki Morikawa, Toshie Fujishima, Hiroaki Isono, Tsutomu Suenaga, Keisuke Takaguchi, Yuri Takao, Takuro Komatsu, Wataru Yonamine

Publikováno v: Tetrahedron. 75:1098-1106

Five novel vitamin D analogues ( 2a , 2b , 3a , 3b and 4 ) bearing an aromatic side chain have been designed and synthesized in a convergent manner. The requisite CD-ring synthons ( 10a–c ) were prepared from C22 aldehyde ( 5 ) using four- or five-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90cfca212710eba6e3d64ae81a2a1078
https://doi.org/10.1016/j.tet.2019.01.019

Zobrazit plný text záznamu

The C4-functionalized 9,10-seco-5,7,10(19)-cholestatriene derivatives: Concise synthesis and characterization of novel vitamin D analogues with a four-membered heterocyclic ether

Autor: Tsutomu Suenega, Toshie Fujishima

Publikováno v: Tetrahedron. 74:1461-1467

Two novel stereoisomeric 9,10-seco-steroids (3a,b) bearing a spiro-oxetane at the C2 position of the A-ring with an unconventional C4-hydroxy group have been designed and synthesized by a convergent manner. The requisite A-ring enyne precursors (±)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3d12ac71b5e8ae95ce313a1186a139a
https://doi.org/10.1016/j.tet.2018.02.001

Zobrazit plný text záznamu

Synthetic Strategy and Biological Activity of A-ring Stereoisomers of 1,25- Dihydroxyvitamin D3 and C2-Modified Analogues

Autor: Takato Nozaki, Toshie Fujishima, Tsutomu Suenaga

Publikováno v: Current Topics in Medicinal Chemistry. 14:2446-2453

The hormonally active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1a), has a wide variety of biological activities and its major molecular target is considered to be the vitamin D receptor (VDR). The A-ring stereoisomers of 1a as well as its C2-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dfb1a76ecf98e1056d905c91ce57335
https://doi.org/10.2174/1568026615666141208102907

Zobrazit plný text záznamu

Concise synthesis and characterization of novel seco-steroids bearing a spiro-oxetane instead of a metabolically labile C3-hydroxy group

Autor: Tsutomu Suenaga, Toshie Fujishima, Takato Nozaki

Publikováno v: Tetrahedron Letters. 55:3805-3808

Two novel stereoisomeric analogues of 1,25-dihydroxyvitamin D3 bearing a spiro-oxetane at the C3 position of the A-ring have been designed and synthesized in a convergent manner. The absolute configuration at the C1 position of the synthesized compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb96daf0f9f85c91dd77423d8873a708
https://doi.org/10.1016/j.tetlet.2014.05.060

Zobrazit plný text záznamu

Design, synthesis and biological evaluation of novel 1α,25-dihydroxyvitamin D3 analogues possessing aromatic ring on 2α-position

Autor: Nozomi Saito, Seishi Kishimoto, Keizo Waku, Hiroaki Takayama, Masaaki Kurihara, Shinobu Honzawa, Yasuhiro Yamamoto, Takayuki Sugiura, Sara Peleg, Atsushi Kittaka, Toshie Fujishima, Koshiro Hirasaka

Publikováno v: Tetrahedron. 61:11253-11263

In the present study, we describe the synthesis of new analogues of 1α,25-dihydroxyvitamin D 3 ( 1 ), which possess hydrophobic aromatic ring on the 2α position. Among these analogues, 2α-benzyl analogue showed the highest potency in the affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa9ff8c8f7704c2b0f8dd6eec0cc7a07
https://doi.org/10.1016/j.tet.2005.08.116

Zobrazit plný text záznamu

The antagonism between 2-methyl-1,25-dihydroxyvitamin D3 and 2-methyl-20-epi-1,25-dihydroxyvitamin D3 in non-genomic pathway-mediated biological responses induced by 1α,25-dihydroxyvitamin D3 assessed by NB4 cell differentiation

Autor: Toshie Fujishima, Daishiro Miura, Anthony W. Norman, Atsushi Kittaka, Hiroaki Takayama, Seiichi Ishizuka, Mathew T. Mizwicki, Katsuhiro Konno

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 94:469-479

We synthesized all eight possible A-ring diastereomers of 2-methyl substituted analogs of 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] and also all eight A-ring diastereomers of 2-methyl-20-epi-1alpha,25(OH)2D3. Their biological activities, espec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9ebe905872ec84470868c41cddcbb6
https://doi.org/10.1016/j.jsbmb.2005.01.025

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání