Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Toshiaki Yamaura"'
Autor:
Go Kasuya, Toshiaki Yamaura, Xiao-Bo Ma, Ryoki Nakamura, Mizuki Takemoto, Hiromitsu Nagumo, Eiichi Tanaka, Naoshi Dohmae, Takanori Nakane, Ye Yu, Ryuichiro Ishitani, Osamu Matsuzaki, Motoyuki Hattori, Osamu Nureki
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
P2X receptors are nonselective cation channels that are gated by extracellular ATP. Here the authors present the crystal structure of chicken P2X7 with its bound competitive antagonist TNP-ATP and give mechanistic insights into TNP-ATP dependent inhi
Externí odkaz:
https://doaj.org/article/cb0f6ce882154f37b17a413f1ef7ef0d
Autor:
Hideki Kakutani, Azusa Takahashi, Masuo Kondoh, Yumiko Saito, Toshiaki Yamaura, Toshiko Sakihama, Takao Hamakubo, Kiyohito Yagi
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16611 (2011)
Recent progress in cell biology has provided new insight into the claudin (CL) family of integral membrane proteins, which contains more than 20 members, as a target for pharmaceutical therapy. Few ligands for CL have been identified because it is di
Externí odkaz:
https://doaj.org/article/5ca5dbfedf3a4ab3b2269f34f694d66e
Autor:
Shino Bito, Toshiaki Yamaura, Kenichiro Takaba, Takayuki Serizawa, Atsutoshi Tazumi, Masashi Ishiguro, Eiichi Tanaka, Natsumi Yamakawa, Yukiko Nagano, Masashi Kawanishi, Masakazu Atobe
Publikováno v:
Journal of Medicinal Chemistry. 63:7143-7162
Two chemical series of novel protein kinase C ζ (PKCζ) inhibitors, 4,6-disubstituted and 5,7-disubstituted isoquinolines, were rapidly identified using our fragment merging strategy. This methodology involves biochemical screening of a high concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463b1e5a57f66dee9797b41ba9988c6d
https://doi.org/10.1021/acs.jmedchem.0c00449
https://doi.org/10.1021/acs.jmedchem.0c00449
Autor:
Motoyuki Hattori, Hiromitsu Nagumo, Mizuki Takemoto, Ye Yu, Naoshi Dohmae, Go Kasuya, Ryoki Nakamura, Eiichi Tanaka, Ryuichiro Ishitani, Toshiaki Yamaura, Takanori Nakane, Xiao-Bo Ma, Osamu Nureki, Osamu Matsuzaki
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7 receptor subtype plays a crucial role in the immune and nervous systems. Altered expression and dysfunctions of P2X7 receptors caused by genetic deletions, mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5863cc214e1904edeec153b40c4e548c
https://pubmed.ncbi.nlm.nih.gov/29026074
https://pubmed.ncbi.nlm.nih.gov/29026074
Autor:
Kiyohito Yagi, Azusa Takahashi, Takao Hamakubo, Hideki Kakutani, Toshiko Sakihama, Masuo Kondoh, Toshiaki Yamaura, Yumiko Saito
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 2, p e16611 (2011)
PLoS ONE, Vol 6, Iss 2, p e16611 (2011)
Recent progress in cell biology has provided new insight into the claudin (CL) family of integral membrane proteins, which contains more than 20 members, as a target for pharmaceutical therapy. Few ligands for CL have been identified because it is di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1caa56b65ca9d99a96d77e4e0bffbb
https://pubmed.ncbi.nlm.nih.gov/21339813
https://pubmed.ncbi.nlm.nih.gov/21339813
Autor:
Satoru Tamura, Atsushi Shiomi, Toshiaki Yamaura, Guang-Ming Yang, Nobutoshi Murakami, Masafumi Kaneko
Publikováno v:
ChemInform. 41
Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10 E ,12 Z )-9-hydroxyoctadeca-10,12-dienoic acid ( 1 ) as an unprecedented NES non-antagonistic inhibitor for nuclear ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c5fd0573fad16564bcac72aaaa698d
https://doi.org/10.1002/chin.201029218
https://doi.org/10.1002/chin.201029218
Autor:
Atsushi Shiomi, Satoru Tamura, Nobutoshi Murakami, Toshiaki Yamaura, Guang-Ming Yang, Masafumi Kaneko
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(6)
Bioassay-guided separation from the MeOH extract of the South American medicinal plant Sida cordifolia resulted in isolation of (10 E ,12 Z )-9-hydroxyoctadeca-10,12-dienoic acid ( 1 ) as an unprecedented NES non-antagonistic inhibitor for nuclear ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4df94c82b3ca52a870ad2fcf3914c55
https://pubmed.ncbi.nlm.nih.gov/20176483
https://pubmed.ncbi.nlm.nih.gov/20176483
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