Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Toshiaki Sawatani"'
Autor:
Bruno Blanchi, Marion Taurand, Claire Colace, Sofia Thomaidou, Charlotte Audeoud, Federica Fantuzzi, Toshiaki Sawatani, Sevda Gheibi, Joan Sabadell-Basallote, Fransje W.J. Boot, Thibault Chantier, Aline Piet, Charlotte Cavanihac, Marion Pilette, Adélie Balguerie, Hamza Olleik, Françoise Carlotti, Miriam Ejarque, Malin Fex, Hindrik Mulder, Miriam Cnop, Decio L. Eizirik, Ouardane Jouannot, Anne-Lise Gaffuri, Paul Czernichow, Arnaud Zaldumbide, Raphaël Scharfmann, Philippe Ravassard
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101772- (2023)
Objectives: Readily accessible human pancreatic beta cells that are functionally close to primary adult beta cells are a crucial model to better understand human beta cell physiology and develop new treatments for diabetes. We here report the charact
Externí odkaz:
https://doaj.org/article/2150f4f22a72439bb1a63dbdb430ec0a
Autor:
Itziar González‐Moro, Koldo Garcia‐Etxebarria, Luis Manuel Mendoza, Nora Fernández‐Jiménez, Jon Mentxaka, Ane Olazagoitia‐Garmendia, María Nicol Arroyo, Toshiaki Sawatani, Cristina Moreno‐Castro, Chiara Vinci, Anne Op de Beek, Miriam Cnop, Mariana Igoillo‐Esteve, Izortze Santin
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Abstract Type 1 diabetes (T1D) is a complex autoimmune disease that develops in genetically susceptible individuals. Most T1D‐associated single nucleotide polymorphisms (SNPs) are located in non‐coding regions of the human genome. Interestingly,
Externí odkaz:
https://doaj.org/article/e0b08b72f8934629b39760d37febee3a
Autor:
Xiaoyan Yi, Bianca Marmontel de Souza, Toshiaki Sawatani, Florian Szymczak, Lorella Marselli, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105376- (2022)
Summary: Target tissues of autoimmune and degenerative diseases show signals of inflammation. We used publicly available RNA-seq data to study whether pancreatic β-cells in type 1 and type 2 diabetes and neuronal tissue in multiple sclerosis and Alz
Externí odkaz:
https://doaj.org/article/98968df14f8745248b90aa1ddd003817
Autor:
Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Toshiaki Sawatani, Nathalie Pachera, Ying Cai, Chiara Vinci, Enrico Virgilio, Laurence Ladriere, Mara Suleiman, Piero Marchetti, Jean-Christophe Jonas, Patrick Gilon, Décio L. Eizirik, Mariana Igoillo-Esteve, Miriam Cnop
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In vitro differentiation of human induced pluripotent stem cells (iPSCs) into beta cells represents an important cell source for diabetes research. Here, we fully characterized iPSC-derived beta cell function in vitro and in vivo in humanized mice. U
Externí odkaz:
https://doaj.org/article/0801cd4a24f44be99a2985f1ef3ecd75
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 178-186 (2019)
The role of type I diacylglycerol kinases (DGKs) in the regulation of insulin secretion was investigated in MIN6 β-cells. In intracellular Ca2+ concentration ([Ca2+]i) measurement experiments, 1 μM R59949, a type I DGK inhibitor, and 10 μM DiC8, a
Externí odkaz:
https://doaj.org/article/84a0827a13314c359af2bf0f6ff72b90
Autor:
Stephanie Bourgeois, Toshiaki Sawatani, Annelore Van Mulders, Nico De Leu, Yves Heremans, Harry Heimberg, Miriam Cnop, Willem Staels
Publikováno v:
Cells, Vol 10, Iss 1, p 191 (2021)
Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is beta cell replacement through the transplantation of islets of L
Externí odkaz:
https://doaj.org/article/eedeb29f275b4f069ce6af802ec7c1b3
Autor:
Arturo Roca-Rivada, Sandra Marín-Cañas, Maikel L. Colli, Chiara Vinci, Toshiaki Sawatani, Lorella Marselli, Miriam Cnop, Piero Marchetti, Decio L. Eizirik
Publikováno v:
Diabetologia.
Autor:
Vyron Gorgogietas, Bahareh Rajaei, Chae Heeyoung, Bruno J. Santacreu, Sandra Marín-Cañas, Paraskevi Salpea, Toshiaki Sawatani, Anyishai Musuaya, María N. Arroyo, Cristina Moreno-Castro, Khadija Benabdallah, Celine Demarez, Sanna Toivonen, Cristina Cosentino, Nathalie Pachera, Maria Lytrivi, Ying Cai, Lode Carnel, Cris Brown, Fumihiko Urano, Piero Marchetti, Patrick Gilon, Decio L. Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Publikováno v:
Diabetologia, Vol. 66, no.7, p. 1306-1321 (2023)
Aims/hypothesis Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, hearing loss and neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c323abf826fb8049db46bad1f9fe4197
https://hdl.handle.net/2078.1/275993
https://hdl.handle.net/2078.1/275993
Autor:
Itziar González-Moro, Koldo Garcia-Etxebarria, Luis Manuel Mendoza, Nora Fernández-Jiménez, Jon Mentxaka-Salgado, Ane Olazagoitia-Garmendia, María Nicol Arroyo, Toshiaki Sawatani, Anne Op de Beek, Miriam Cnop, Mariana Igoillo-Esteve, Izortze Santin
SummaryType 1 diabetes-associated single nucleotide polymorphisms are mainly located in non-coding regions of the human genome. Single nucleotide polymorphisms located in long non-coding RNAs may result in the disruption of their secondary structure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed04dc76b7bd0a247bac8f6027de8f5e
https://doi.org/10.1101/2022.12.01.518685
https://doi.org/10.1101/2022.12.01.518685
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(5)
Depression of lipid metabolism in β-cells has been indicated to be one of the causes of impaired insulin secretion in type 2 diabetes. Diacylglycerol (DAG) is an important lipid mediator and is known to regulate insulin secretion in pancreatic β-ce