Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Toshiaki Isobe"'
Autor:
K. Shanmugha Rajan, Saurav Aryal, Disha-Gajanan Hiregange, Anat Bashan, Hava Madmoni, Mika Olami, Tirza Doniger, Smadar Cohen-Chalamish, Pascal Pescher, Masato Taoka, Yuko Nobe, Aliza Fedorenko, Tanaya Bose, Ella Zimermann, Eric Prina, Noa Aharon-Hefetz, Yitzhak Pilpel, Toshiaki Isobe, Ron Unger, Gerald F. Späth, Ada Yonath, Shulamit Michaeli
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114203- (2024)
Summary: Leishmania is the causative agent of cutaneous and visceral diseases affecting millions of individuals worldwide. Pseudouridine (Ψ), the most abundant modification on rRNA, changes during the parasite life cycle. Alterations in the level of
Externí odkaz:
https://doaj.org/article/1af39d1e364149228194dd16b1cc4963
Autor:
K. Shanmugha Rajan, Hava Madmoni, Anat Bashan, Masato Taoka, Saurav Aryal, Yuko Nobe, Tirza Doniger, Beathrice Galili Kostin, Amit Blumberg, Smadar Cohen-Chalamish, Schraga Schwartz, Andre Rivalta, Ella Zimmerman, Ron Unger, Toshiaki Isobe, Ada Yonath, Shulamit Michaeli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Trypanosomes are protozoan parasites that cycle between insect and mammalian hosts and are the causative agent of sleeping sickness. Here, we describe the changes of pseudouridine (Ψ) modification on rRNA in the two life stages of the paras
Externí odkaz:
https://doaj.org/article/13fe9a6c17164bf5b6d6496ccbcea44a
Autor:
Shotaro Nakano, Soshiro Kashio, Kei Nishimura, Asuka Takeishi, Hina Kosakamoto, Fumiaki Obata, Erina Kuranaga, Takahiro Chihara, Yoshio Yamauchi, Toshiaki Isobe, Masayuki Miura
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010761 (2023)
The mechanisms by which the innate immune system senses damage have been extensively explored in multicellular organisms. In Drosophila, various types of tissue damage, including epidermal injury, tumor formation, cell competition, and apoptosis defi
Externí odkaz:
https://doaj.org/article/c45fdfff80af4a68814e7b8e62a55463
Autor:
Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L. Jaffe, Ada Yonath, Georgios Skiniotis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highligh
Externí odkaz:
https://doaj.org/article/4b7b9a6e66c84f36a4b0e669a2a51d88
Autor:
Keiichi Izumikawa, Yuko Nobe, Harunori Yoshikawa, Hideaki Ishikawa, Yutaka Miura, Hiroshi Nakayama, Takashi Nonaka, Masato Hasegawa, Naohiro Egawa, Haruhisa Inoue, Kouki Nishikawa, Koji Yamano, Richard J. Simpson, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Nobuhiro Takahashi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The 43-kDa trans-activating response region DNA-binding protein 43 (TDP-43) is a product of a causative gene for amyotrophic lateral sclerosis (ALS). Despite of accumulating evidence that mitochondrial dysfunction underlies the pathogenesis
Externí odkaz:
https://doaj.org/article/9971d9fd83d945bca18af986cb1ebe25
Autor:
Zhikuan Zhang, Umeharu Ohto, Takuma Shibata, Masato Taoka, Yoshio Yamauchi, Ryota Sato, Nikunj M. Shukla, Sunil A. David, Toshiaki Isobe, Kensuke Miyake, Toshiyuki Shimizu
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3371-3381.e5 (2018)
Summary: Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA (ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 shows synergistic activation in response to two ligands, guanosine and
Externí odkaz:
https://doaj.org/article/375b181e186041cc9c1479bbedd8b5ba
Autor:
Ania Naila Guerrieri, Federico Zacchini, Carmine Onofrillo, Sara Di Viggiano, Marianna Penzo, Alessio Ansuini, Ilaria Gandin, Yuko Nobe, Masato Taoka, Toshiaki Isobe, Davide Treré, Lorenzo Montanaro
Publikováno v:
Cancers, Vol 12, Iss 12, p 3512 (2020)
Dyskerin is a nucleolar protein involved in the small nucleolar RNA (snoRNA)-guided pseudouridylation of specific uridines on ribosomal RNA (rRNA), and in the stabilization of the telomerase RNA component (hTR). Loss of function mutations in DKC1 cau
Externí odkaz:
https://doaj.org/article/bdc890046e084d0a93fb5a78fa564c47
Autor:
Junya Unno, Akiko Itaya, Masato Taoka, Koichi Sato, Junya Tomida, Wataru Sakai, Kaoru Sugasawa, Masamichi Ishiai, Tsuyoshi Ikura, Toshiaki Isobe, Hitoshi Kurumizaka, Minoru Takata
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1039-1047 (2014)
The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand cr
Externí odkaz:
https://doaj.org/article/e36387d2c5d74315a6dd602ff2eac987
Autor:
Masato Taoka, Daisuke Ishikawa, Yuko Nobe, Hideaki Ishikawa, Yoshio Yamauchi, Goro Terukina, Hiroshi Nakayama, Kouji Hirota, Nobuhiro Takahashi, Toshiaki Isobe
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112156 (2014)
The eukaryotic small-subunit (SSU) ribosomal RNA (rRNA) has two evolutionarily conserved acetylcytidines. However, the acetylation sites and the acetyltransferase responsible for the acetylation have not been identified. We performed a comprehensive
Externí odkaz:
https://doaj.org/article/fcc9b8517d9b4d6c9e02c685c8361313
Autor:
Yuichiro Saito, Jun Takeda, Kousuke Adachi, Yuko Nobe, Junya Kobayashi, Kouji Hirota, Douglas V Oliveira, Masato Taoka, Toshiaki Isobe
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112488 (2014)
Ribonuclease mitochondrial RNA processing (RNase MRP) is a multifunctional ribonucleoprotein (RNP) complex that is involved in the maturation of various types of RNA including ribosomal RNA. RNase MRP consists of a potential catalytic RNA and several
Externí odkaz:
https://doaj.org/article/bd9ab841e4fc47328e50796e83f9cc8f