Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Toshiaki Imoto"'
Autor:
Seiji Nakamura, Yuzo Ninomiya, Noriatsu Shigemura, Keisuke Sanematsu, Toshiaki Imoto, Takatsugu Hirokawa, Yuko Kusakabe
Publikováno v:
Journal of Biological Chemistry. 289:25711-25720
Gymnemic acids are triterpene glycosides that selectively suppress taste responses to various sweet substances in humans but not in mice. This sweet-suppressing effect of gymnemic acids is diminished by rinsing the tongue with γ-cyclodextrin (γ-CD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb0c02b9ba2bd1c39a13f57da846d55
https://doi.org/10.1074/jbc.m114.560409
https://doi.org/10.1074/jbc.m114.560409
Autor:
Megumi Maruyama, Osamu Shido, Naoki Moriyama, Tatsuo Watanabe, Toshiaki Imoto, Michio Miyoshi
Publikováno v:
European Journal of Pharmacology. 541:38-43
Polymyxin B, a cyclic cationic polypeptide antibiotic, binds to the lipid A of bacterial endotoxin (lipopolysaccharide; LPS) to inhibit LPS-induced fever. On the basis of a casual observation, we hypothesised that in rats (unlike in rabbits and goats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31563f5c75d44a935b7edbe5ab35caab
https://doi.org/10.1016/j.ejphar.2006.05.006
https://doi.org/10.1016/j.ejphar.2006.05.006
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:1163-1170
We investigated whether natriuretic peptide (NP) acts as an endogenous antipyretic inside and/or outside the blood-brain barrier in rats made febrile by systemic administration of bacterial endotoxin (lipopolysaccharide; LPS). Intravenous (i.v.) inje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0912668f46c2841d334f524dab2076
https://doi.org/10.1124/jpet.106.102731
https://doi.org/10.1124/jpet.106.102731
Publikováno v:
FEBS Journal. 272:6154-6160
The physiological phenomenon that the antisweet taste effect of gymnemic acid (GA) is diminished by application of γ-cyclodextrin (γ-CD) to the mouth was evaluated at the molecular level using isothermal titration calorimetry, NMR and dynamic light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4635ec075ece37ef72b3056a751460e8
https://doi.org/10.1111/j.1742-4658.2005.05014.x
https://doi.org/10.1111/j.1742-4658.2005.05014.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:865-873
We recently reported an involvement of peripheral angiotensin II (ANG II) in the development of both the fever and the peripheral interleukin (IL)-1beta production induced in rats by a systemic injection of lipopolysaccharide (LPS). The present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b828101eaf70ef378fa1609f1f2b97ac
https://doi.org/10.1124/jpet.103.060392
https://doi.org/10.1124/jpet.103.060392
Autor:
Taisaku Funakoshi, Hajime Miyata, Toshiaki Imoto, Nobuyuki Endo, Chun Hui Yang, Keisuke Makino, Toshiyuki Arai, Eisaku Ohama
Publikováno v:
Neuropathology. 23:161-168
Neuroprotective effects of 6-formylpterin (6FP) on transient retinal ischemia-reperfusion injury were evaluated in rats by means of counting the number of retinal ganglion cells, measuring the thicknesses of the inner plexiform and inner nuclear laye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373212f79706567eead7727aa7b5cc87
https://doi.org/10.1046/j.1440-1789.2003.00493.x
https://doi.org/10.1046/j.1440-1789.2003.00493.x
Publikováno v:
Journal of Neurophysiology. 90:911-923
We examined the effect of the sweet transduction blocker gurmarin on taste responses recorded from neurons in the rat solitary nucleus (NST) to determine how gurmarin sensitivity is distributed across neuronal type. Initially, responses evoked by was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75626bfff08be43ad4341d3058d6da79
https://doi.org/10.1152/jn.00215.2003
https://doi.org/10.1152/jn.00215.2003
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 79:836-840
Our recent study in mice revealed that the inhibitory activity of gurmarin on the sweet taste responses was reduced significantly by the presence of β-cyclodextrin (β-CD). To investigate the mechanism involved in the action of β-CD, physicochemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eca27f0f658a8210c134e5b5ce42b2d
https://doi.org/10.1139/y01-064
https://doi.org/10.1139/y01-064
Autor:
Minoru Wada, Makoto Hashimoto, Daikai Sadamitsu, Michio Miyoshi, Tatsuo Watanabe, Toshiaki Imoto, Tsuyoshi Maekawa
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 279:R1512-R1516
It has been reported that a host develops a marked fever under dehydrated conditions compared with normally hydrated conditions (11). The present study was carried out to investigate whether ANG II is involved in the enhancement seen in dehydrated ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03243b16306faf518b0aa38fc2d22548
https://doi.org/10.1152/ajpregu.2000.279.4.r1512
https://doi.org/10.1152/ajpregu.2000.279.4.r1512
Publikováno v:
Chemical Senses. 24:387-392
Gymnema sylvestre, a tropical plant, contains gurmarin that selectively suppresses sucrose responses of the chorda tympani nerve in rats and mice. We investigated preference for taste solutions and saliva composition in rats fed a diet containing thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4205e415bee4f855300cac492000b7
https://doi.org/10.1093/chemse/24.4.387
https://doi.org/10.1093/chemse/24.4.387