Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Toshiaki Imagawa"'
Autor:
Hirotaka Watanabe, Kojiro Ishibashi, Hiroki Mano, Sho Kitamoto, Nanami Sato, Kazuya Hoshiba, Mugihiko Kato, Fumihiko Matsuzawa, Yasuto Takeuchi, Takanobu Shirai, Susumu Ishikawa, Yuka Morioka, Toshiaki Imagawa, Kazuyasu Sakaguchi, Suguru Yonezawa, Shunsuke Kon, Yasuyuki Fujita
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3721-3729 (2018)
Summary: p53 is a tumor suppressor protein, and its missense mutations are frequently found in human cancers. During the multi-step progression of cancer, p53 mutations generally accumulate at the mid or late stage, but not in the early stage, and th
Externí odkaz:
https://doaj.org/article/7b3d5f86dea4489d8d609ac4b73d0b9d
Autor:
Rui Kamada, Shuya Sakaguchi, Shoma Kura, Kaori Takamatsu, Tetsuya Yamamoto, Toshiaki Imagawa, Kazuyasu Sakaguchi
Publikováno v:
Chemistry Letters. 51:1029-1032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d9ee6e4703927c029af42f8656bbc11
https://doi.org/10.1246/cl.220340
https://doi.org/10.1246/cl.220340
Autor:
Tatsuki Tsuruoka, Emiri Nakayama, Takuya Endo, Shingo Harashima, Rui Kamada, Kazuyasu Sakaguchi, Toshiaki Imagawa
Publikováno v:
Journal of Cell Science; Jun2023, Vol. 136 Issue 12, p1-14, 14p
Autor:
Tatsuki Tsuruoka, Emiri Nakayama, Takuya Endo, Shingo Harashima, Rui Kamada, Kazuyasu Sakaguchi, Toshiaki Imagawa
The tumor suppressor p53 plays a central role in cellular stress responses by regulating transcription of multiple target genes. The temporal dynamics of p53 are thought to be important for its function: it encode input information and are decoded to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74352b066347122316dda2172563d92
https://doi.org/10.1101/2022.08.03.502578
https://doi.org/10.1101/2022.08.03.502578
Autor:
Fumihiko Matsuzawa, Yuka Morioka, Mugihiko Kato, Kazuya Hoshiba, Kojiro Ishibashi, Toshiaki Imagawa, Takanobu Shirai, Sho Kitamoto, Shunsuke Kon, Yasuyuki Fujita, Nanami Sato, Kazuyasu Sakaguchi, Susumu Ishikawa, Yasuto Takeuchi, Suguru Yonezawa, Hirotaka Watanabe, Hiroki Mano
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3721-3729 (2018)
Summary: p53 is a tumor suppressor protein, and its missense mutations are frequently found in human cancers. During the multi-step progression of cancer, p53 mutations generally accumulate at the mid or late stage, but not in the early stage, and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bd4da2d64e0546de85a01526099462
https://doi.org/10.1016/j.celrep.2018.05.081
https://doi.org/10.1016/j.celrep.2018.05.081
Publikováno v:
Chemistry Letters. 47:217-220
p53 acts as a transcriptional factor for tumor suppression via tetramerization. Although the dominant-negative effect occurs by hetero-oligomerization between wild-type and mutant p53, the precise mechanism remains unclear. Here, we report an analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4de3012d9d3958b57630655e3714d0f8
https://doi.org/10.1246/cl.170980
https://doi.org/10.1246/cl.170980
Publikováno v:
Biopolymers. 106:598-612
Tetramer formation of p53 is essential for its tumor suppressor function. p53 not only acts as a tumor suppressor protein by inducing cell cycle arrest and apoptosis in response to genotoxic stress, but it also regulates other cellular processes, inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::776da1f0e79cb2254712b17989aef682
https://doi.org/10.1002/bip.22772
https://doi.org/10.1002/bip.22772
Autor:
Yoshiro Chuman, Takahiro Michiba, Kazuyasu Sakaguchi, Sari Ogasawara, Toshiaki Imagawa, Rui Kamada
Publikováno v:
Journal of biochemistry. 165(6)
The protein phosphatase PPM1D (Wip1) was originally identified as a p53 target product. Activation of PPM1D through various mechanism promotes the tumorigenic potential of various cancers by suppressing p53 and other DNA damage response proteins. New
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39c8d74c021224aa6d0e1dd8fa09390e
https://pubmed.ncbi.nlm.nih.gov/30576481
https://pubmed.ncbi.nlm.nih.gov/30576481
Autor:
Makoto Tominaga, Toshio Ohta, Toshiaki Imagawa, Kenji Takahashi, Makiko Kashio, Nagako Banzawa, Shigeru Saito
Publikováno v:
Journal of Biological Chemistry. 289:31927-31939
The transient receptor potential ankyrin 1 (TRPA1) is a Ca2+-permeable, nonselective cation channel mainly expressed in a subset of nociceptive neurons. TRPA1 functions as a cellular sensor detecting mechanical, chemical, and thermal stimuli. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf45d55194b13e2a4c4275edbe34b6bf
https://doi.org/10.1074/jbc.m114.586891
https://doi.org/10.1074/jbc.m114.586891
Autor:
Shigeru Saito, Kenji Takahashi, Claire T. Saito, Toshio Ohta, Nagako Banzawa, Toshiaki Imagawa, Naomi Fukuta, Makoto Tominaga
Publikováno v:
Molecular Biology and Evolution. 31:708-722
Nociceptive receptors enable animals to sense tissue-damaging stimuli, thus playing crucial roles in survival. Due to evolutionary diversification, responses of nociceptive receptors to specific stimuli can vary among species. Multispecies functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2260a01d3e49ba468b4b3817d91e6f7
https://doi.org/10.1093/molbev/msu001
https://doi.org/10.1093/molbev/msu001